Abstract: The present application relate to crystalline azide compound of formula (II) which is used as an intermediate for the preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof. The present application also covers purification process of azide compound of formula (II) and its further conversion to eribulin or a pharmaceutically acceptable salts thereof.

Abstract: A system and method for creating shortcuts within a database for archived items. A client computer sends a retrieval request for a given item to a web server. The given item may be an electronic document. A custom HTTPModule within the web server intercepts the request. The HTTPModule uses a uniform resource locator (URL) provided in the request to locate a record associated with the given item. If a given fixed string value is read from the record in place of the original content data, then the web server requests original content data for the given item from an archive store. The record still maintains identification information, such as a document identifier and the URL in order to maintain links and workflows. The retrieval request is not rerouted to an alternate path, and the client computer receives the original content data, rather than an indication of a shortcut.

Abstract: A system and method for creating shortcuts within a database for archived items. A client computer sends a retrieval request for a given item to a web server. The given item may be an electronic document. A custom HTTPModule within the web server intercepts the request. The HTTPModule uses a uniform resource locator (URL) provided in the request to locate a record associated with the given item. If a given fixed string value is read from the record in place of the original content data, then the web server requests original content data for the given item from an archive store. The record still maintains identification information, such as a document identifier and the URL in order to maintain links and workflows. The retrieval request is not rerouted to an alternate path, and the client computer receives the original content data, rather than an indication of a shortcut.

Abstract: A system and method for creating shortcuts within a database for archived items. A client computer sends a retrieval request for a given item to a web server. The given item may be an electronic document. A custom HTTPModule within the web server intercepts the request. The HTTPModule uses a uniform resource locator (URL) provided in the request to locate a record associated with the given item. If a given fixed string value is read from the record in place of the original content data, then the web server requests original content data for the given item from an archive store. The record still maintains identification information, such as a document identifier and the URL in order to maintain links and workflows. The retrieval request is not rerouted to an alternate path, and the client computer receives the original content data, rather than an indication of a shortcut.

Abstract: A process for the asymmetric transformation of a racemic compound of formula (I) wherein R1 is H or a alkyl group having up to 20 carbon atoms, R2 is H, or an alkyl, aryl, alkaryl or aralkyl group having up to 20 carbon atoms, and X is H, a halogen atom, tert-butyl, or any other removable substituent, comprises reaction of racemic compound (I) with an enantiomerically-enriched acid HY*, wherein Y* is a chiral group, to form a diastereomeric salt of compound (I) having Y* as a counterion. The salt obtained can then be reduced to give enantiomerically-enriched galanthamine, or a derivative thereof.

Abstract: A process for preparing a compound having formula (11), comprises oxidative cyclization of a tertiary amine having formula (12), wherein X.sup.1 is a removable functionality, X.sup.2 is hydrogen or a group as defined above for X.sup.1, and R.sup.1 is selected from hydrogen and alkyl, aryl, alkaryl and aralkyl groups having up to 20 carbon atoms, and R.sup.2 and R.sup.3 are independently selected from hydrogen and alkyl, aryl, alkaryl, aralkyl and acyl groups having up to 20 carbon atoms. Novel compounds are both used and produced by that process.