Abstract: The present disclosure relates to modified immunocytokine compositions comprising antibodies or antigen binding fragments specific for immune cell antigens and IL-18 polypeptides. Also provided herein are methods of treatment with and methods of manufacture of immunocytokine compositions.

Abstract: Techniques and mechanisms for identifying unmanaged cloud resources with endpoint and network logs and attributing the identified cloud resources to an entity of an enterprise that owns the cloud resources. The process collects data from sources, e.g., endpoint and network logs, with respect to traffic in a computer network and based at least in part on the data, extracts relationships related to the traffic. The process applies rules to the relationships to extract destinations in the computer network that provide cloud resources in a cloud environment, wherein the cloud resources are owned by an enterprise. One or more users or business entities of the enterprise are identified as accessing the cloud resources.

Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: A tracheostomy guard couples with a patient interface to reduce the risk of occlusion of the patient interface. The tracheostomy guard has features that may prevent accidental disconnection from the patient interface while enabling suction to be applied to a patient. The tracheostomy guard may prevent patient secretions from being communicated with a caregiver in use.

Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: Techniques and mechanisms for identifying unmanaged cloud resources with endpoint and network logs and attributing the identified cloud resources to an entity of an enterprise that owns the cloud resources. The process collects data from sources, e.g., endpoint and network logs, with respect to traffic in a computer network and based at least in part on the data, extracts relationships related to the traffic. The process applies rules to the relationships to extract destinations in the computer network that provide cloud resources in a cloud environment, wherein the cloud resources are owned by an enterprise. One or more users or business entities of the enterprise are identified as accessing the cloud resources.

Abstract: A non-transitory machine-readable medium having machine-executable instructions includes a translator, the machine-readable instructions for the translator being executable by a processor core to perform operations. The operations include translating records in model-based system engineering (MBSE) data for an MBSE platform to identify nodes and links for graph data of a graph database. The operations also include populating the graph data with the nodes and links from the translated nodes. A query to the graph data of the graph database reveals a subset of nodes of the nodes and links between the nodes of the subset of nodes and other nodes of the nodes of the graph data.

Abstract: A tracheostomy guard couples with a patient interface to reduce the risk of occlusion of the patient interface. The tracheostomy guard has features that may prevent accidental disconnection from the patient interface while enabling suction to be applied to a patient. The tracheostomy guard may prevent patient secretions from being communicated with a caregiver in use.

Abstract: Techniques and mechanisms for identifying unmanaged cloud resources with endpoint and network logs and attributing the identified cloud resources to an entity of an enterprise that owns the cloud resources. The process collects data from sources, e.g., endpoint and network logs, with respect to traffic in a computer network and based at least in part on the data, extracts relationships related to the traffic. The process applies rules to the relationships to extract destinations in the computer network that provide cloud resources in a cloud environment, wherein the cloud resources are owned by an enterprise. One or more users or business entities of the enterprise are identified as accessing the cloud resources.

Abstract: The present invention relates to methods for treatment of lung cancers, in particular non-small cell lung cancer (NSCLC), wherein lung cancers have both a KRAS G12C mutation and an STK11 mutation, with adagrasib (MRTX849).

Abstract: The present disclosure relates a modified interleukin 18 (IL-18) polypeptide, methods of making the same, and methods of using the modified IL-18 polypeptides for treatment of diseases including cancer. The modified IL-18 polypeptide can exhibit an ability to induce interferon gamma (IFN?) production when in contact with a cell, exhibit a diminished ability to be inhibited by IL-18 binding protein (IL-18BP) compared to wild type IL-18 (WT IL-18), and exhibit a ratio of half-maximal inhibitory concentration (IC50) by IL-18BP to half-maximal effective concentration (EC50) to induce IFN? production which is greater than that of WT IL-18.

Abstract: The present disclosure relates to modified immunocytokine compositions comprising antibodies or antigen binding fragments specific for immune cell antigens and IL-18 polypeptides. Also provided herein are methods of treatment with and methods of manufacture of immunocytokine compositions.

Abstract: A connector is described that may be configured to connect between a first tube and a second tube. The connector has an internal component and an external component. The external component has a first end and a second end. The first end has an external taper and an internal coupling face that may be configured to interact with the first tube and the second end may be configured to interact with the second tube. The internal component may be configured to rotate independently to the external component. The external component has a gripping region to aid the user in disconnection of the connector. An attachment mechanism may attach the second tube to the internal component.

Abstract: A connector is described that may be configured to connect between a first tube and a second tube. The connector has an internal component and an external component. The external component has a first end and a second end. The first end has an external taper and an internal coupling face that may be configured to interact with the first tube and the second end may be configured to interact with the second tube. The internal component may be configured to rotate independently to the external component. The external component has a gripping region to aid the user in disconnection of the connector. An attachment mechanism may attach the second tube to the internal component.

Abstract: Techniques and mechanisms for identifying unmanaged cloud resources with endpoint and network logs and attributing the identified cloud resources to an entity of an enterprise that owns the cloud resources. The process collects data from sources, e.g., endpoint and network logs, with respect to traffic in a computer network and based at least in part on the data, extracts relationships related to the traffic. The process applies rules to the relationships to extract destinations in the computer network that provide cloud resources in a cloud environment, wherein the cloud resources are owned by an enterprise. One or more users or business entities of the enterprise are identified as accessing the cloud resources.

Abstract: A respiratory humidification system humidifies a flow of respiratory gases supplied to a user. The system can include a main housing that receives a humidification chamber, a heating plate included in the main housing and positioned to contact the humidified chamber and transfer heat to the humidifier chamber, and a heating element that provides heat to the heating plate. The heating element can include a temperature sensor disposed in a central region of the heating element. Disposing the temperature sensor in the central region can reduce a likelihood that conductors of the heating element will cause an incorrect temperature measurement by the temperature sensor.

Abstract: A respiratory humidification system humidifies a flow of respiratory gases supplied to a user. The system can include a main housing that receives a humidification chamber, a heating plate included in the main housing and positioned to contact the humidified chamber and transfer heat to the humidifier chamber, and a heating element that provides heat to the heating plate. The heating element can include a temperature sensor disposed in a central region of the heating element. Disposing the temperature sensor in the central region can reduce a likelihood that conductors of the heating element will cause an incorrect temperature measurement by the temperature sensor.