Patents by Inventor Andrew Coats

Andrew Coats has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250228608
    Abstract: A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.
    Type: Application
    Filed: November 22, 2024
    Publication date: July 17, 2025
    Applicant: Fractyl Health, Inc.
    Inventors: Jay Caplan, Harith Rajagopalan, Mark A. Manasas, Christopher J. Kadamus, Andrew Coats, Philip S. Levin, J. Christopher Flaherty
  • Publication number: 20250228600
    Abstract: A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.
    Type: Application
    Filed: December 19, 2024
    Publication date: July 17, 2025
    Applicant: Fractyl Health, Inc.
    Inventors: Philip S. Levin, Jay Caplan, Harith Rajagopalan, Mark A. Manasas, Andrew Coats, J. Christopher Flaherty
  • Publication number: 20250231197
    Abstract: Disclosed herein are methods and compositions for the detection of biomarkers for cardiac diseases. Disclosed herein are sample collection devices comprising detection devices for heart failure. Disclosed herein are methods of detecting, monitoring, preventing, or treating heart failure.
    Type: Application
    Filed: August 20, 2024
    Publication date: July 17, 2025
    Inventors: Leo de Bruin, Gustav de Bruin, Andrew Coats
  • Publication number: 20250127551
    Abstract: A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.
    Type: Application
    Filed: December 31, 2024
    Publication date: April 24, 2025
    Applicant: Fractyl Health, Inc.
    Inventors: Jay Caplan, Philip D. Levin, Andrew Coats, Harith Rajagopalan, Mark A. Manasas, J. Christopher Flaherty
  • Patent number: 12280244
    Abstract: An active injection guide concurrently monitors surface contact and an instantaneous contact force along an injection axis of an injector in order to ensure that the injector is properly positioned on a patient before an injection can be initiated.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: April 22, 2025
    Assignee: Portal Instruments, Inc.
    Inventors: Robert J. Dyer, Andrew Coats, Patrick Anquetil
  • Patent number: 12252491
    Abstract: The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: March 18, 2025
    Assignee: ELI LILLY AND COMPANY
    Inventors: David Andrew Coates, Kwame Frimpong, William Glen Holloway, Brian Spencer Jones, Adam Marc Levinson, Charles Willis Lugar, III, Michael Enrico Richett, Brian Morgan Watson, Michael Edward Woodman
  • Patent number: 12201342
    Abstract: A system for treatment target tissue comprises an ablation device and an energy delivery unit. The ablation device comprises an elongate tube with an expandable treatment element. The system delivers a thermal dose of energy to treat the target tissue. Methods of treating target tissue are also provided.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: January 21, 2025
    Assignee: Fractyl Health, Inc.
    Inventors: Philip S. Levin, Jay Caplan, Harith Rajagopalan, Mark A. Manasas, Andrew Coats, J. Christopher Flaherty
  • Publication number: 20250019363
    Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.
    Type: Application
    Filed: September 27, 2024
    Publication date: January 16, 2025
    Inventors: Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
  • Patent number: 12178502
    Abstract: A device for expanding tissue comprises at least one fluid delivery tube and at least one fluid delivery element in fluid communication with the at least one fluid delivery tube. The at least one fluid delivery tube comprises a proximal end, a distal end, and a lumen therebetween. The device is constructed and arranged to perform a near full circumferential expansion of luminal wall tissue. Systems and methods are also provided, including a system for expanding tissue layers and treating tissue proximate to the expanded tissue layers.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: December 31, 2024
    Assignee: Fractyl Health, Inc.
    Inventors: Jay Caplan, Harith Rajagopalan, Mark A. Manasas, Christopher James Kadamus, Andrew Coats, Philip S. Levin, J. Christopher Flaherty
  • Patent number: 12140598
    Abstract: Disclosed herein are methods and compositions for the detection of biomarkers for cardiac diseases. Disclosed herein are sample collection devices comprising detection devices for heart failure. Disclosed herein are methods of detecting, monitoring, preventing, or treating heart failure.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: November 12, 2024
    Assignee: Endothelium Scanning Nanotechnology Limited
    Inventors: Leo De Bruin, Gustav De Bruin, Andrew Coats
  • Patent number: 12089887
    Abstract: A device for ablating target tissue of a patient with an ablative fluid is provided. An elongate shaft includes a proximal portion and a distal portion, and at least one fluid delivery element is attached to the distal portion. The device can be configured to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: September 17, 2024
    Assignee: Fractyl Health, Inc.
    Inventors: Jay Caplan, Philip S. Levin, Andrew Coats, Harith Rajagopalan, Mark A. Manasas, J. Christopher Flaherty
  • Patent number: 12071423
    Abstract: The embodiments of present invention provide processes for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: August 27, 2024
    Assignee: Eli Lilly and Company
    Inventors: Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
  • Patent number: 11999722
    Abstract: The present invention provides a compound of Formula I. or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: June 4, 2024
    Assignee: ELI LILLY AND COMPANY
    Inventors: David Andrew Coates, Timothy Barrett Durham, Richard Duane Johnston, Steven Marc Massey, Patrick Gianpietro Spinazze, Douglas Richard Stack, James Lee Toth
  • Patent number: 11980743
    Abstract: An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: May 14, 2024
    Assignee: Portal Instruments, Inc.
    Inventors: Andrew Coats, Robert J. Dyer
  • Publication number: 20240082258
    Abstract: Disclosed herein are methods and compositions for the detection of biomarkers for cardiac diseases. Disclosed herein are sample collection devices comprising detection devices for heart failure. Disclosed herein are methods of detecting, monitoring, preventing, or treating heart failure.
    Type: Application
    Filed: September 21, 2023
    Publication date: March 14, 2024
    Inventors: Leo DE BRUIN, Gustav DE BRUIN, Andrew Coats
  • Publication number: 20240075213
    Abstract: A needleless injection system includes a pusher that pushes a plunger within a tapered bore of a cartridge. The pusher includes a nib, the tip of which is a ball.
    Type: Application
    Filed: September 15, 2023
    Publication date: March 7, 2024
    Inventors: Jessica Ong, Robert J. Dyer, Andrew Coats, Nikolay Lapin
  • Publication number: 20240059666
    Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.
    Type: Application
    Filed: October 18, 2023
    Publication date: February 22, 2024
    Inventors: Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
  • Patent number: 11834435
    Abstract: The present invention relates to specific salts of (1S,5R)-(1?,5?,6?)-N-[1,1-dimethyl-2-[(3-methyl-2-pyridyl)oxy]ethyl]-3-azabicyclo[3.1.0]hexane-6-carboxamide, to pharmaceutical compositions comprising said salts, to methods of using said salts to treat physiological disorders, and to intermediates useful in the synthesis of the salts.
    Type: Grant
    Filed: September 14, 2022
    Date of Patent: December 5, 2023
    Assignee: Eli Lilly and Company
    Inventors: David Andrew Coates, David Michael Remick
  • Patent number: 11827618
    Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.
    Type: Grant
    Filed: April 14, 2023
    Date of Patent: November 28, 2023
    Inventors: Aktham Aburub, David Andrew Coates, Scott Alan Frank, Mark Steven Kerr, Roger Ryan Rothhaar, Radhe Krishan Vaid
  • Publication number: 20230372627
    Abstract: An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.
    Type: Application
    Filed: August 2, 2023
    Publication date: November 23, 2023
    Inventors: Andrew Coats, Robert J. Dyer