Abstract: The present technology addresses the problem of quickly and safely improving policies in online reinforcement learning domains. As its solution, an exploration strategy comprising diverse exploration (DE) is employed, which learns and deploys a diverse set of safe policies to explore the environment. DE theory explains why diversity in behavior policies enables effective exploration without sacrificing exploitation. An empirical study shows that an online policy improvement algorithm framework implementing the DE strategy can achieve both fast policy improvement and safe online performance.

Abstract: A wearable device includes: at least one compliant region adapted and configured to be placed over a joint of a subject and at least two flexible but less compliant regions coupled to opposite ends of the compliant region. The device provides a wearable robotic device including a wearable and at least one actuator adapted and configured to move the flexible but less compliant regions relative to each other.

Abstract: One aspect of the invention provides a wearable device including: at least one compliant region adapted and configured to be placed over a joint of a subject and at least two flexible but less compliant regions coupled to opposite ends of the compliant region. Another aspect of the invention provides a wearable robotic device including a wearable device as described herein and at least one actuator adapted and configured to move the flexible but less compliant regions relative to each other.

Abstract: The present application provides bifunctional compounds of Formula I or II: or an enantiomer, diastereomer, or stereoisomer, or a pharmaceutically acceptable salt thereof, which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds of Formula (I) or (II) that link a mutant cereblon-binding moiety to a ligand that is capable of binding to a targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. The present application also relates to polynucleotides or polypeptides of a mutant cereblon and methods of use thereof.

Abstract: The present application provides bifunctional compounds of Formula I or II: or an enantiomer, diastereomer, or stereoisomer, or a pharmaceutically acceptable salt thereof, which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds of Formula (I) or (II) that link a mutant cereblon-binding moiety to a ligand that is capable of binding to a targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof. The present application also relates to polynucleotides or polypeptides of a mutant cereblon and methods of use thereof.

Abstract: A system is enabled to create an application, for use by devices, by using an intermediary agent to efficiently transform an existing monitored application. The intermediary agent is configured to attach to at least one monitored application executed on at least one server and to create a session corresponding to at least one client application executed on at least one client wherein execution of the client application is at least partially based on a message between the server and the client. The intermediary agent is also configured to intercept the message to identify at least one change in the state of the monitored application and to transmit the message to a transformation module upon detection of at least one change in the state of the monitored application. The transformation module is configured to determine whether the communication message should be modified prior to being transmitted to the client.

Abstract: At least one server connects with clients via networks such that each client communicates using a different network. The server divides an image based on an application into portions. The server assigns version numbers to the portions such that each version number corresponds to a different portion. The server generates lists that include the version numbers, wherein each list corresponds to a different client. The server shares the image by transmitting image data to each client separately based on the respective list. The server receives update(s) for the image and identifies portion(s) that has changed based on the update. The server assigns an updated version number to the identified changed portion and generates updated lists that include the updated version numbers for the clients such that each updated list corresponds to a different client. The server transmits updated image data to each client separately based on the respective updated list.

Abstract: A knee joint prosthesis which comprises a tibial component (4, 6) and a femoral component (2). The femoral component has condyles (14, 16) which act against the tibial component, directly or indirectly, during flexing of the knee. A cam (20) on the femoral component acts against a post (26) on the tibial component at high flex angles. The surface of the post which is contacted by the cam at high flex angles is convex when the post viewed generally perpendicular to the tibial bone contact and bearing surfaces, and the femoral bearing surface which is provided by the cam, where it contacts the convex surface of the post at high flex angles, is locally concave (32) when viewed along the surface of the post which contacts the cam so that the area of contact between the post and the cam is greater at high flex angles than at lower flex angles.

Abstract: At least one server receives at least one signal representing a request for an initiation of the server for the installation and configuration of an application. The server connects with client(s) after receiving the signal and transmits at least one display image to the client such that the client can render the display image via a web interface, wherein the display image provides information regarding the server. The server receives an application installer, wherein the client is can use the web interface to facilitate transmission of the application installer. The server installs and configures the application based on at least one input received from the client, wherein the client is enabled to use the web interface to facilitate transmitting the input to the server. The server generates an image based on the application configuration and transmits the image to a data management system for storage until deployment.

Abstract: One aspect of the invention provides a wearable device including: at least one compliant region adapted and configured to be placed over a joint of a subject and at least two flexible but less compliant regions coupled to opposite ends of the compliant region. Another aspect of the invention provides a wearable robotic device including a wearable device as described herein and at least one actuator adapted and configured to move the flexible but less compliant regions relative to each other.

Abstract: At least one server receives at least one signal representing a request for an initiation of the server for the installation and configuration of an application. The server connects with client(s) after receiving the signal and transmits at least one display image to the client such that the client can render the display image via a web interface, wherein the display image provides information regarding the server. The server receives an application installer, wherein the client is can use the web interface to facilitate transmission of the application installer. The server installs and configures the application based on at least one input received from the client, wherein the client is enabled to use the web interface to facilitate transmitting the input to the server. The server generates an image based on the application configuration and transmits the image to a data management system for storage until deployment.

Abstract: A knee joint prosthesis which comprises a tibial component (4, 6) and a femoral component (2). The femoral component has condyles (14, 16) which act against the tibial component, directly or indirectly, during flexing of the knee. A cam (20) on the femoral component acts against a post (26) on the tibial component at high flex angles. The surface of the post which is contacted by the cam at high flex angles is convex when the post viewed generally perpendicular to the tibial bone contact and bearing surfaces, and the femoral bearing surface which is provided by the cam, where it contacts the convex surface of the post at high flex angles, is locally concave (32) when viewed along the surface of the post which contacts the cam so that the area of contact between the post and the cam is greater at high flex angles than at lower flex angles.

Abstract: A knee joint prosthesis which comprises a tibial component (4, 6) and a femoral component (2). The femoral component has condyles (14, 16) which act against the tibial component, directly or indirectly, during flexing of the knee. A cam (20) on the femoral component acts against a post (26) on the tibial component at high flex angles. The surface of the post which is contacted by the cam at high flex angles is convex when the post viewed generally perpendicular to the tibial bone contact and bearing surfaces, and the femoral bearing surface which is provided by the cam, where it contacts the convex surface of the post at high flex angles, is locally concave (32) when viewed along the surface of the post which contacts the cam so that the area of contact between the post and the cam is greater at high flex angles than at lower flex angles.

Abstract: A computer-implemented method is disclosed having the steps of receiving a user input selecting an entity name, and generating an entity table associated with the entity name and configured to store data related to a business unit. The method further includes the steps of populating the entity table with unique explicit entity ID values, generating a unique internal entity ID value for each one of the explicit entity ID values, associating each internal entity ID value with a corresponding one of the explicit entity ID values, and storing the internal entity ID values in the entity table. The entity table is associated with a separate data table such that at least one of the explicit entity ID values is displayed, but not stored, in an ID field of the data table, while the corresponding associated internal entity ID value is stored in the data table but not displayed.

Abstract: A vessel for dehydrating a natural gas stream using molecular sieve material contained therein and a method for designing such a vessel are described. The vessel includes cylindrical vessel walls having a plurality of thermally conductive plates attached to the inner surface thereof. The plurality of thermally conductive plates are distributed vertically and circumferentially through the cylindrical portion of the vessel. The dimensions of the thermally conductive plates can be determined using computational fluid dynamics analysis of a process for regenerating the molecular sieve material. It is possible to reduce the duration of operation in regeneration mode using the vessel of the present disclosure.

Abstract: At least one server receives at least one signal representing a request for an initiation of the server for the installation and configuration of an application. The server connects with client(s) after receiving the signal and transmits at least one display image to the client such that the client can render the display image via a web interface, wherein the display image provides information regarding the server. The server receives an application installer, wherein the client is can use the web interface to facilitate transmission of the application installer. The server installs and configures the application based on at least one input received from the client, wherein the client is enabled to use the web interface to facilitate transmitting the input to the server. The server generates an image based on the application configuration and transmits the image to a data management system for storage until deployment.

Abstract: At least one server connects with clients via networks such that each client communicates using a different network. The server divides an image based on an application into portions. The server assigns version numbers to the portions such that each version number corresponds to a different portion. The server generates lists that include the version numbers, wherein each list corresponds to a different client. The server shares the image by transmitting image data to each client separately based on the respective list. The server receives update(s) for the image and identifies portion(s) that has changed based on the update. The server assigns an updated version number to the identified changed portion and generates updated lists that include the updated version numbers for the clients such that each updated list corresponds to a different client. The server transmits updated image data to each client separately based on the respective updated list.

Abstract: A computer-implemented method is disclosed having the steps of receiving a user input selecting an entity name, and generating an entity table associated with the entity name and configured to store data related to a business unit. The method further includes the steps of populating the entity table with unique explicit entity ID values, generating a unique internal entity ID value for each one of the explicit entity ID values, associating each internal entity ID value with a corresponding one of the explicit entity ID values, and storing the internal entity ID values in the entity table. The entity table is associated with a separate data table such that at least one of the explicit entity ID values is displayed, but not stored, in an ID field of the data table, while the corresponding associated internal entity ID value is stored in the data table but not displayed.

Abstract: A knee joint prosthesis which comprises a tibial component (4, 6) and a femoral component (2). The femoral component has condyles (14, 16) which act against the tibial component, directly or indirectly, during flexing of the knee. A cam (20) on the femoral component acts against a post (26) on the tibial component at high flex angles. The surface of the post which is contacted by the cam at high flex angles is convex when the post viewed generally perpendicular to the tibial bone contact and bearing surfaces, and the femoral bearing surface which is provided by the cam, where it contacts the convex surface of the post at high flex angles, is locally concave (32) when viewed along the surface of the post which contacts the cam so that the area of contact between the post and the cam is greater at high flex angles than at lower flex angles.