Abstract: A stand mixer includes a housing, a motor disposed in the housing, a mixing shaft operably coupled to the motor, a controller, and an accelerometer in data communication with the controller. The controller is configured to receive tap data from the accelerometer, determine a command based upon the tap data from the accelerometer, and operate the stand mixer in response to the determined command.

Abstract: The present invention provides freebase and salt forms useful for treating various CDK4-mediated and a CDK6-mediated disorders, such as cancer, by the administration of small molecule therapeutics that act as inhibitors of CDK4 and CDK6. Pharmaceutical compositions comprising the freebase and salt forms, as well as methods of their use and preparation, are also described.

Abstract: A method includes operating a mixing cycle of a stand mixer. The mixing cycle includes rotating a mixing shaft at a first speed for a first period of time, rotating, when the first period of time elapses, the mixing shaft at a second speed, measuring a torque of a motor while rotating the mixing shaft at the second speed, and then rotating the mixing shaft at the first speed for a second period of time. The method further includes terminating the mixing cycle in response to one of the torque of the motor and elapsing the second period of time.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: Provided is a method for operating a stand mixer. The stand mixer includes a housing, a motor disposed in the housing, a mixing shaft operably coupled to the motor, and a controller. The method includes receiving, at the controller, a command indicative of starting an active stir mode, rotating, by the motor, the mixing shaft in a variable direction in the active stir mode, thereby stirring food contents, and terminating, by the controller, the active stir mode in response to one of a user input and reaching a predetermined time.

Abstract: A stand mixer includes a housing, a motor disposed in the housing, and a controller. The method includes operating the motor to mix food contents, receiving, at the controller, a measurement of an operating parameter of the motor of the stand mixer while operating the motor to mix the food contents, filtering, by the controller, a noise interference from the measurement of the operating parameter of the motor, determining, at the controller, a desired end time based on the filtered measurement of the operating parameter of the motor, and continuing to operate the motor to mix the food contents until reaching the desired end time, whereby the mixing operation is completed.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: An ignition system for igniting a gas burner of an appliance includes a gas burner, an electric igniter assembly, a pilot light, and a controller. The pilot light is ignitable by the electric igniter assembly. The controller is configured to operate the electric igniter assembly for ignition of the gas burner, detect a power disruption event, ignite the pilot light using the electric igniter assembly in response to detecting the power disruption event, and use the pilot light for ignition of the gas burner during the power disruption event. Methods of operating the ignition system for igniting the gas burner of the appliance are also provided.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: The disclosure is directed to compounds of Formula I pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use and preparation, are also described.

Abstract: A device includes a code that is interpretable to identify a three-dimensional (3D) design specification by which a replacement for the device can be printed on a 3D printer.

Abstract: A device includes a code that is interpretable to identify a three-dimensional (3D) design specification by which a replacement for the device can be printed on a 3D printer.

Abstract: A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.

Abstract: A method and system for electronically facilitating real estate transactions by providing accurate representations of the loans a borrower is qualified to receive, which are based on actual data, rather than estimates. All actions required for completing the real estate transaction, from entry of the borrower information to the closing and funding of the loan, are seamlessly integrated. An automated underwriting engine is provided for generating a decision matrix based on user input and/or existing data. An appropriate loan is selected based on the decision matrix, and is communicated to a potential borrower. After a loan is selected, fulfillment processing is performed, and the loan is funded and closed.