Abstract: The present invention relates to eliciting an immune response in a subject by sole administration of an adjuvant, wherein the adjuvant is associated with a population of polymersomes.

Abstract: The present invention relates to a method of modulating Th1/Th2 immune response by administering a population of polymersomes having an associated antigen together with a population of polymersomes having an associated adjuvant as well as compositions comprising the two populations of polymersomes.

Abstract: Methods and apparatus for configuring reduced decode ranges for barcode scanners are disclosed. An example method includes determining a closest focus distance of a plurality of focus distances at which a barcode placed at a furthest limit of a reduced decode range can be successfully decoded; determining a furthest focus distance of the plurality of focus distances at which the barcode placed at a closest limit of the reduced decode range can be successfully decoded; determining a subset of the plurality of focus distances that consists of the closest focus distance, the furthest focus distance, and focus distances between the closest focus distance and the farthest focus distance; and configuring the barcode scanner to only use the subset of focus distances during subsequent attempts to decode barcodes.

Abstract: The present invention relates to a polymersome comprising a soluble encapsulated antigen, wherein the soluble encapsulated antigen is a soluble fragment of a Spike protein of a human-pathogenic coronavirus, as well as a combination of a population of such polymersomes, and a second population of polymersomes comprising an encapsulated adjuvant. The present invention also relates to related methods, such as methods of treatment, kits, compositions, such a vaccine, and medical uses, such as in the treatment of a human-pathogenic coronavirus infection.

Abstract: The present invention relates to a method of eliciting an immune response in a subject by administration of an antigen and an adjuvant, wherein the antigen is associated with a first population of polymersomes, and wherein the adjuvant is associated with a second population of polymersomes, and wherein the two populations of polymersomes are administered to the subject. The present invention also relates to compositions such as vaccines comprising the two polymersome populations of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: An apparatus and method for updating features on an image scanning apparatus has a client computing device capture and decode an image of a first symbol that encodes data that identifies the image scanning apparatus, request a server to enable a feature on the image scanning apparatus, receive activation data from the server to enable the feature, and generate an image of a second symbol on a display of the client computing device that encodes the activation data. The image scanning apparatus captures and decodes an image of the second symbol, and uses the decoded activation data to enable a feature resident on the image scanning apparatus or to request a download of the feature from the client computing device if the feature is not resident on the image scanning apparatus. The client computing device downloads the feature from the server, and uploads the feature to the image scanning apparatus.

Abstract: The present invention relates to polymersomes capable of eliciting an immune response, comprising: an antigen selected from the group consisting of: (a) a polypeptide; (b) a carbohydrate; (c) a polynucleotide; and (d) a combination of (a) and/or (b) and/or (c); wherein the antigen is conjugated to the exterior surface of the polymersome via a covalent bond. The present invention further relates to a method for production of antigens conjugated to a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention.

Abstract: The present invention relates to polymersomes comprising a soluble encapsulated antigen, wherein said soluble encapsulated antigen is selected from the group consisting of: a polypeptide, a carbohydrate, a polynucleotide and combinations thereof. The present invention further relates to a method for production of encapsulated antigens in a polymersome as well as to polymersomes produced by said method. The present invention further relates to compositions comprising a polymersome of the present invention, isolated antigen presenting cells or hybridoma cells exposed to the polymersome or composition of the present invention. The present invention also relates to vaccines comprising polymersomes of the present invention, methods of eliciting an immune response or methods for treatment, amelioration, prophylaxis or diagnostics of a cancer, autoimmune or infectious disease, comprising providing polymersomes of the present invention.

Abstract: An apparatus and method for updating features on an image scanning apparatus has a client computing device capture and decode an image of a first symbol that encodes data that identifies the image scanning apparatus, request a server to enable a feature on the image scanning apparatus, receive activation data from the server to enable the feature, and generate an image of a second symbol on a display of the client computing device that encodes the activation data. The image scanning apparatus captures and decodes an image of the second symbol, and uses the decoded activation data to enable a feature resident on the image scanning apparatus or to request a download of the feature from the client computing device if the feature is not resident on the image scanning apparatus. The client computing device downloads the feature from the server, and uploads the feature to the image scanning apparatus.

Abstract: Methods and systems for disabling barcode reader illumination and aiming operation based on barcode reader position are disclosed herein. An example method includes a barcode reader determining its angular position, for example, from an accelerometer mounted in the barcode reader. That angular position is compared against a reference angular position and a determination is made whether barcode reader is in a disable angular region. When in the disable angular region, the barcode reader automatically disables illumination and/or aiming operation until the angular position enters an enable angular region. That enable angular region may be different than the disable angular region, and both may be adjustable.

Abstract: A clip includes a base that is elongated in a longitudinal direction, a post connected to the base at a proximal end of the post. The post extends away from the base and terminates at a distal end of the post. The clip further includes a first finger and a second finger both connected on opposite sides of the post and extending away from the post toward the base in the longitudinal direction. The clip also includes an elongated foot connected to the base on a side of the base opposite the post. The clip also includes an umbrella seal connected to the base that has a sealing lip around a periphery of the base that extends away from the base. The base, the elongated foot and the first finger and the second finger of the clip extend along the same longitudinal direction of the clip.

Abstract: A method and apparatus for calibrating a client computing device for decoding symbols includes an imaging assembly for capturing images of a symbol of known size and density. Each image, or set of images, is captured using a different setting or value of a parameter of the imaging assembly of the client computing device. Each image, or set of images, is decoded, and the fastest decode-time determines the default settings/values for the parameters.

Abstract: An apparatus and method for updating features on an image scanning apparatus has a client computing device capture and decode an image of a first symbol that encodes data that identifies the image scanning apparatus, request a server to enable a feature on the image scanning apparatus, receive activation data from the server to enable the feature, and generate an image of a second symbol on a display of the client computing device that encodes the activation data. The image scanning apparatus captures and decodes an image of the second symbol, and uses the decoded activation data to enable a feature resident on the image scanning apparatus or to request a download of the feature from the client computing device if the feature is not resident on the image scanning apparatus. The client computing device downloads the feature from the server, and uploads the feature to the image scanning apparatus.

Abstract: A clip includes a base that is elongated in a longitudinal direction, a post connected to the base at a proximal end of the post. The post extends away from the base and terminates at a distal end of the post. The clip further includes a first finger and a second finger both connected on opposite sides of the post and extending away from the post toward the base in the longitudinal direction. The clip also includes an elongated foot connected to the base on a side of the base opposite the post. The clip also includes an umbrella seal connected to the base that has a sealing lip around a periphery of the base that extends away from the base. The base, the elongated foot and the first finger and the second finger of the clip extend along the same longitudinal direction of the clip.

Abstract: The present invention provides an analyte detection device. The device comprises first and second zones, means to allow addition of a probe to the first zone, means to allow addition of a sample suspected to contain an analyte and means to allow passage of the probe from the first zone to the second zone. The first zone contains ligands reactive with the analyte and the second zone includes a membrane the impedance of which is dependent on the presence or absence of the probe and means to measure the impedance of the membrane. It is preferred that the probe includes an ionophore, preferably gramicidin. The present invention also relates to methods of detecting the presence of an analyte.

Abstract: The present invention provides an analyte detection device. The device comprises first and second zones, means to allow addition of a probe to the first zone, means to allow addition of a sample suspected to contain an analyte and means to allow passage of the probe from the first zone to the second zone. The first zone contains ligands reactive with the analyte and the second zone includes a membrane the impedance of which is dependent on the presence or absence of the probe and means to measure the impedance of the membrane. It is preferred that the probe includes an ionophore, preferably gramicidin. The present invention also relates to methods of detecting the presence of an analyte.

Abstract: The present invention provides a biosensor for use in detecting the presence of an enzyme or enzymes in a sample. The biosensor comprises a membrane and means for determining the impedance of the membrane. The membrane includes ionophores therein to which are attached linkers. The linkers are cleavable by the enzyme or enzymes to be detected, with the cleavage of the linker causing a change in the ability of ions to pass through the membrane via the ionophores.

Abstract: A membrane comprising a closely packed array of self-assembling amphiphilic molecules, and is characterized in that it incorporates a plurality of ion channels, and/or at least a proportion of the self-assembling molecules comprise a receptor molecule conjugated with a supporting entity. The ion channel is selected from the group consisting of peptides capable of forming helices and aggregates thereof, corronands, cryptands, podands and combinations thereof. In the amphiphilic molecules comprising a receptor molecule conjugated with a supporting entity, the receptor molecule has a receptor site and is selected from the group consisting of immunoglobulins, antibodies, antibody fragments, dyes enzymes and lectins. "The supporting entity is selected from the group consisting of a lipid head group, a hydrocarbon chain(s), a cross-linkable molecule and a membrane protein. The supporting entity is attached to the receptor molecule at tan end remote from the receptor site.

Abstract: The present invention provides a biosensor that detects an analyte in a sample by measuring the response of a membrane within which associated ion channels undergo state changes upon interaction between the analyte and the ionic channels. The state change response is detected as result of the change in ionic flow through the membrane.

Abstract: The present invention provides a method of detecting an analyte in a sample the method comprising adding a sample suspected of containing the analyte to a membrane comprising a closely packed array of self-assembling amphiphilic molecules, the membrane including a plurality of ion channels selected from the group consisting of peptides capable of forming helices and aggregates thereof, podands cryptands and coronands, a first receptor moiety reactive with the analyte being attached to the ion channel at an end thereof, the first receptor moiety being such that it normally exists in a first state, but when bound to the analyte exists in a second state, said change of state of the first receptor moiety causing a change in the ability of ions to pass through the ion channel, the first receptor moiety being selected from the group consisting of antigens, peptides, antibodies (e.g.