Patents by Inventor Andrew Crews
Andrew Crews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230371942Abstract: Surgical tools that are capable of both manipulating a needle and cutting surgical thread during a suturing operation can sometimes be problematic due to inadvertent severing of the surgical thread. Surgical tools capable of exposing a bladed cutting surface only when severing of surgical thread is desired can substantially alleviate this issue. Such surgical tools may comprise an end effector comprising an end effector axle, a first jaw and a second jaw rotatably mounted to the end effector axle, and a first cutting body having a first blade and second cutting body having a second blade. The first cutting body is configured to move in tandem with the first jaw and the second cutting body is configured to move in tandem with the second jaw, such that the first and second blades are occluded when the first and second jaws are closed or partially opened.Type: ApplicationFiled: August 7, 2023Publication date: November 23, 2023Inventors: Andrew Crews, Michael Chirumbolo, John A. Hibner, Rudolph H. Nobis
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Patent number: 11717282Abstract: Surgical tools that are capable of both manipulating a needle and cutting surgical thread during a suturing operation can sometimes be problematic due to inadvertent severing of the surgical thread. Surgical tools capable of exposing a bladed cutting surface only when severing of surgical thread is desired can substantially alleviate this issue. Such surgical tools may comprise an end effector comprising an end effector axle, a first jaw and a second jaw rotatably mounted to the end effector axle, and a first cutting body having a first blade and second cutting body having a second blade. The first cutting body is configured to move in tandem with the first jaw and the second cutting body is configured to move in tandem with the second jaw, such that the first and second blades are occluded when the first and second jaws are closed or partially opened.Type: GrantFiled: October 26, 2020Date of Patent: August 8, 2023Assignee: Cilag GmbH InternationalInventors: Andrew Crews, Michael Chirumbolo, John Hibner, Rudolph Nobis
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Patent number: 11076927Abstract: A method of operating a surgical tool includes mounting the surgical tool to a tool driver. The surgical tool includes one or more drive cables movable to actuate an end effector, and one or more segments are defined along a portion of at least one of the one or more drive cables and each segment exhibits a usage value. Usage of the drive cables is monitored with a computer system in communication with the tool driver, and the usage value of one or more of the segments is altered based on usage of the surgical tool.Type: GrantFiled: November 13, 2018Date of Patent: August 3, 2021Inventors: John A. Hibner, Andrew Crews
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Publication number: 20210038215Abstract: Surgical tools that are capable of both manipulating a needle and cutting surgical thread during a suturing operation can sometimes be problematic due to inadvertent severing of the surgical thread. Surgical tools capable of exposing a bladed cutting surface only when severing of surgical thread is desired can substantially alleviate this issue. Such surgical tools may comprise an end effector comprising an end effector axle, a first jaw and a second jaw rotatably mounted to the end effector axle, and a first cutting body having a first blade and second cutting body having a second blade. The first cutting body is configured to move in tandem with the first jaw and the second cutting body is configured to move in tandem with the second jaw, such that the first and second blades are occluded when the first and second jaws are closed or partially opened.Type: ApplicationFiled: October 26, 2020Publication date: February 11, 2021Applicant: Ethicon LLCInventors: Andrew Crews, Michael Chirumbolo, John Hibner, Rudolph Nobis
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Patent number: 10820898Abstract: Surgical tools that are capable of both manipulating a needle and cutting surgical thread during a suturing operation can sometimes be problematic due to inadvertent severing of the surgical thread. Surgical tools capable of exposing a bladed cutting surface only when severing of surgical thread is desired can substantially alleviate this issue. Such surgical tools may comprise an end effector comprising an end effector axle, a first jaw and a second jaw rotatably mounted to the end effector axle, and a first cutting body having a first blade and second cutting body having a second blade. The first cutting body is configured to move in tandem with the first jaw and the second cutting body is configured to move in tandem with the second jaw, such that the first and second blades are occluded when the first and second jaws are closed or partially opened.Type: GrantFiled: October 5, 2017Date of Patent: November 3, 2020Assignee: Ethicon LLCInventors: Andrew Crews, Michael Chirumbolo, John Hibner, Rudolph Nobis
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Publication number: 20200146765Abstract: A method of operating a surgical tool includes mounting the surgical tool to a tool driver. The surgical tool includes one or more drive cables movable to actuate an end effector, and one or more segments are defined along a portion of at least one of the one or more drive cables and each segment exhibits a usage value. Usage of the drive cables is monitored with a computer system in communication with the tool driver, and the usage value of one or more of the segments is altered based on usage of the surgical tool.Type: ApplicationFiled: November 13, 2018Publication date: May 14, 2020Applicant: Ethicon LLCInventors: John A. Hibner, Andrew Crews
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Publication number: 20190105032Abstract: Surgical tools that are capable of both manipulating a needle and cutting surgical thread during a suturing operation can sometimes be problematic due to inadvertent severing of the surgical thread. Surgical tools capable of exposing a bladed cutting surface only when severing of surgical thread is desired can substantially alleviate this issue. Such surgical tools may comprise an end effector comprising an end effector axle, a first jaw and a second jaw rotatably mounted to the end effector axle, and a first cutting body having a first blade and second cutting body having a second blade. The first cutting body is configured to move in tandem with the first jaw and the second cutting body is configured to move in tandem with the second jaw, such that the first and second blades are occluded when the first and second jaws are closed or partially opened.Type: ApplicationFiled: October 5, 2017Publication date: April 11, 2019Applicant: Ethicon LLCInventors: Andrew Crews, Michael Chirumbolo, John Hibner, Rudolph Nobis
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Patent number: 10071164Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.Type: GrantFiled: August 10, 2015Date of Patent: September 11, 2018Assignees: Yale University, Arvinas, Inc.Inventors: Andrew Crew, Craig Crews, Hanqing Dong, Eunhwa Ko, Jing Wang
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Patent number: 9687302Abstract: A surgical apparatus includes a cannula and a surgical instrument. The cannula includes a curved longitudinal axis along at least a portion of its length. The surgical instrument includes an elongated shaft having a distal end and a proximal end, and an end effector coupled to the distal end of the elongated shaft. At least a portion of the end effector is configured to contact an inner surface of the cannula during insertion of the surgical instrument into the curved cannula. A threshold galling stress between the portion of the end effector and an inner surface of the curved cannula is at least 10,000 pounds per square inch.Type: GrantFiled: January 7, 2014Date of Patent: June 27, 2017Assignee: INTUITIVE SURGICAL OPERATIONS, INC.Inventors: Samuel T. Crews, Andrew Crews, Edward P. Donlon, Craig Gerbi, Kenneth L. Gong, Karnarnadakala D. Krishnanand, Peling Lee, Theodore W. Rogers, John Ryan Steger, Charles E. Swinehart
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Publication number: 20160045607Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.Type: ApplicationFiled: August 10, 2015Publication date: February 18, 2016Inventors: Andrew Crew, Craig Crews, Hanqing Dong, Eunhwa Ko, Jing Wang
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Patent number: 8990743Abstract: Methods and apparatuses to automatically modify a circuit design (e.g., a synthesis solution) according to the sensitivity in design parameters with respect to the possible deviation in the subsequent implementation (e.g., placement and routing) of the circuit. In one aspect of the present invention, a method to design a circuit includes: determining likelihood of a design constraint being violated in an implementation of a first circuit design (e.g., a technology specific netlist with or without a placement solution); and, modifying the first circuit design to reduce the likelihood of the design constraint being violated. In one example, the implementation of the first circuit design includes a routing solution for implementing the first circuit design; and, the first circuit is modified through sizing an instance of a logic element, buffering a signal, load shielding for a signal, or other operations.Type: GrantFiled: March 29, 2012Date of Patent: March 24, 2015Assignee: Synopsys, Inc.Inventors: Champaka Ramachandran, Andrew Crews, Kenneth S. McElvain
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Publication number: 20140194895Abstract: A surgical apparatus includes a cannula and a surgical instrument. The cannula includes a curved longitudinal axis along at least a portion of its length. The surgical instrument includes an elongated shaft having a distal end and a proximal end, and an end effector coupled to the distal end of the elongated shaft. At least a portion of the end effector is configured to contact an inner surface of the cannula during insertion of the surgical instrument into the curved cannula. A threshold galling stress between the portion of the end effector and an inner surface of the curved cannula is at least 10,000 pounds per square inch.Type: ApplicationFiled: January 7, 2014Publication date: July 10, 2014Applicant: INTUITIVE SURGICAL OPERATIONS, INC.Inventors: Samuel T. CREWS, Andrew CREWS, Edward P. DONLON, Craig GERBI, Kenneth L. GONG, Krish KRISHNANAND, Peling LEE, Theodore W. ROGERS, John Ryan STEGER, Charles E. SWINEHART
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Publication number: 20120185811Abstract: Methods and apparatuses to automatically modify a circuit design (e.g., a synthesis solution) according to the sensitivity in design parameters with respect to the possible deviation in the subsequent implementation (e.g., placement and routing) of the circuit. In one aspect of the present invention, a method to design a circuit includes: determining likelihood of a design constraint being violated in an implementation of a first circuit design (e.g., a technology specific netlist with or without a placement solution); and, modifying the first circuit design to reduce the likelihood of the design constraint being violated. In one example, the implementation of the first circuit design includes a routing solution for implementing the first circuit design; and, the first circuit is modified through sizing an instance of a logic element, buffering a signal, load shielding for a signal, or other operations.Type: ApplicationFiled: March 29, 2012Publication date: July 19, 2012Inventors: Champaka Ramachandran, Andrew Crews, Kenneth S. McElvain
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Patent number: 8151228Abstract: Methods and apparatuses to automatically modify a circuit design (e.g., a synthesis solution) according to the sensitivity in design parameters with respect to the possible deviation in the subsequent implementation (e.g., placement and routing) of the circuit. In one aspect of the present invention, a method to design a circuit includes: determining likelihood of a design constraint being violated in an implementation of a first circuit design (e.g., a technology specific netlist with or without a placement solution); and, modifying the first circuit design to reduce the likelihood of the design constraint being violated. In one example, the implementation of the first circuit design includes a routing solution for implementing the first circuit design; and, the first circuit is modified through sizing an instance of a logic element, buffering a signal, load shielding for a signal, or other operations.Type: GrantFiled: December 11, 2006Date of Patent: April 3, 2012Assignee: Synopsys, Inc.Inventors: Champaka Ramachandran, Andrew Crews, Kenneth S. McElvain
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Patent number: 7829717Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.Type: GrantFiled: September 15, 2005Date of Patent: November 9, 2010Assignee: OSI Pharmaceuticals, Inc.Inventors: Arlindo L. Castelhano, Andrew Crew, Hanqing Dong, An-Hu Li, Li Qiu, Alun Smith, Lawrence Tardibono, Tao Zhang
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Patent number: 7618965Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.Type: GrantFiled: September 15, 2005Date of Patent: November 17, 2009Assignee: OSI Pharmaceuticals, Inc.Inventors: Andrew Crew, An-Hu Li, Bijoy Panicker
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Patent number: 7439256Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5 and J are defined herein, are useful in the treatment of cancer.Type: GrantFiled: September 15, 2005Date of Patent: October 21, 2008Inventors: Arlindo Castelhano, Andrew Crew, Hanqing Dong, An-Hu Li, Li Qiu, Alun Smith
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Publication number: 20080221187Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.Type: ApplicationFiled: August 16, 2004Publication date: September 11, 2008Inventors: Joshua Bolger, Arlindo Castelhano, Andrew Crew, Radoslaw Laufer, An-Hu Li, Colin Sambrook Smith, Yingchuan Sun
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Publication number: 20080221153Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.Type: ApplicationFiled: August 16, 2004Publication date: September 11, 2008Inventors: Arlindo Castelhano, Andrew Crew, Han-Qing Dong, Radoslaw Laufer, An-Hu Li, Li Qiu, Colin Sambrook Smith, Tao Zhang
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Patent number: 7388012Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.Type: GrantFiled: September 15, 2005Date of Patent: June 17, 2008Assignee: OSI Pharmaceuticals, Inc.Inventors: Andrew Crew, An-Hu Li, Hanqing Dong, Tao Zhang