Abstract: A novel and powerful fluence and beam orientation optimization package for radiotherapy optimization, called PARETO (Pareto-Aware Radiotherapy Evolutionary Treatment Optimization), makes use of a multi-objective genetic algorithm capable of optimizing several objective functions simultaneously and mapping the structure of their trade-off surface efficiently and in detail. PARETO generates a database of Pareto non-dominated solutions and allows the graphical exploration of trade-offs between multiple planning objectives during IMRT treatment planning PARETO offers automated and truly multi-objective treatment plan optimization, which does not require any objective weights to be chosen, and therefore finds a large sample of optimized solutions defining a trade-off surface, which represents the range of compromises that are possible.

Abstract: A novel and powerful fluence and beam orientation optimization package for radiotherapy optimization, called PARETO (Pareto-Aware Radiotherapy Evolutionary Treatment Optimization), makes use of a multi-objective genetic algorithm capable of optimizing several objective functions simultaneously and mapping the structure of their trade-off surface efficiently and in detail. PARETO generates a database of Pareto non-dominated solutions and allows the graphical exploration of trade-offs between multiple planning objectives during IMRT treatment planning PARETO offers automated and truly multi-objective treatment plan optimization, which does not require any objective weights to be chosen, and therefore finds a large sample of optimized solutions defining a trade-off surface, which represents the range of compromises that are possible.

Abstract: A method and apparatus for treating altitude related illnesses and/or injuries are provided. Example embodiments provide a hyperbaric therapy device (“HTD”) which includes a chamber constructed substantially from a light weight, high strength, substantially air impermeable material, such as a flexible composite laminate material, such that the chamber can maintain an internal air pressure that is higher than ambient air pressure. In some embodiments, an opening in the chamber of the HTD may be sealed by way of a roll-down, dry bag style closure. The chamber of the HTD may also include multiple inflation valves, to support multiple pump systems for efficient inflation and pressure maintenance. The HTD may also include a storage bag that doubles as a pump for inputting air into the chamber of the HTD.