Patents by Inventor Andrew D Gribble

Andrew D Gribble has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease inhibitors
    Patent number: 6566373
    Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: May 20, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Andrew D Gribble, Ashley Edward Fenwick, Robert W Marquis, Daniel F Veber, Jason Witherington
  • Protease inhibitors
    Publication number: 20020082426
    Abstract: 1
    Type: Application
    Filed: February 27, 2002
    Publication date: June 27, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Ashley E. Fenwick, Andrew D. Gribble, Robert W. Marquis, Jason Witherington
  • Protease inhibitors
    Publication number: 20020013360
    Abstract: The invention relates to 3-hydroxy-and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy-or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
    Type: Application
    Filed: July 30, 2001
    Publication date: January 31, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Andrew D. Gribble, Ashley Edward Fenwick, Robert W. Marquis, Daniel F. Veber, Jason Witherington
  • Phenylderivate as inhibitors of ATP citrate lyase
    Patent number: 5447954
    Abstract: Compounds of the formula ##STR1## where the substituents are defined in the specification useful in the treatment of hyperlipidemia.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: September 5, 1995
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Andrew D. Gribble, Pieter H. E. Groot, Antony N. Shaw, Roland E. Dolle
  • Sulphonamido containing phenylalkanoic acids as thromboxane A.sub.2 antagonists
    Patent number: 5280043
    Abstract: Phenylalkanoic acids containing a sulphonamido group, and their use in a method of treatment of thromboxane-A.sub.2 mediated diseases are disclosed. A compound of the invention is 4-[4-(phenyl-sulphonamido)phenyl]butyric acid.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: January 18, 1994
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David G. Cooper, Andrew D. Gribble
  • Biologically active compounds
    Patent number: 4866076
    Abstract: The invention provides a class of sulphonamide-containing tetrahydroisoquinolinyl compounds having thromboxane antagonist activity.
    Type: Grant
    Filed: July 21, 1988
    Date of Patent: September 12, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Andrew D. Gribble
  • Pharmaceutically active compounds
    Patent number: 4812573
    Abstract: The invention relates to a class of tetrahydroisoquinolinylalkanoic acids containing an aryl sulphonamide group which have activity as thromboxane A.sub.2 antagonists.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: March 14, 1989
    Assignee: SmithKline & French Laboratories, Ltd.
    Inventors: Graham J. Durant, Andrew D. Gribble, Robert A. Slater
  • Histamine antagonist triadiazole derivatives, compositions, and method of use therefor
    Patent number: 4728648
    Abstract: New 3,4-diamino-1,2,5-thiadiazole oxide derivatives which are histamine H.sub.1 -antagonists. A specific compound of this invention is 3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-yl-amino]propylamino]-4-[pyrimidin-4-yl -methylamino]-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: March 1, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife
  • Tricyclic derivatives and pharmaceutical use
    Patent number: 4668671
    Abstract: This invention describes tricyclic derivatives which are useful as histamine H.sub.1 -antagonists. A particular compound of this invention is 3-[3-(pyrido[3,2-b][1,4]-benzothiazin-10-yl)propylamino]-4-(pyrid-4-ylmeth ylamino)-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: May 26, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife