Patents by Inventor Andrew D. Kroeker

Andrew D. Kroeker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for enhancing transport of molecules into cells
    Patent number: 10905782
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 2, 2021
    Assignee: Sarepta Therapeutics, inc.
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, David A. Stein, Andrew D. Kroeker
  • Compositions For Enhancing Transport Of Molecules Into Cells
    Publication number: 20200016280
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Application
    Filed: April 9, 2019
    Publication date: January 16, 2020
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, David A. Stein, Andrew D. Kroeker
  • Compositions for enhancing transport of molecules into cells
    Patent number: 10300149
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: May 28, 2019
    Assignee: SAREPTA THERAPEUTICS, INC.
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, David A. Stein, Andrew D. Kroeker
  • Compositions for enhancing transport of molecules into cells
    Patent number: 9572899
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: February 21, 2017
    Assignee: AVI BIOPHARMA, INC.
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, Andrew D. Kroeker, David A. Stein
  • COMPOSITIONS FOR ENHANCING TRANSPORT OF MOLECULES INTO CELLS
    Publication number: 20090082547
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Application
    Filed: November 5, 2008
    Publication date: March 26, 2009
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, Andrew D. Kroeker, David A. Stein
  • Compositions for enhancing transport of molecules into cells
    Patent number: 7468418
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: December 23, 2008
    Assignee: AVI BioPharma., Inc.
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, Andrew D. Kroeker, David A. Stein
  • Compositions for enhancing transport of molecules into cells
    Publication number: 20040265879
    Abstract: Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
    Type: Application
    Filed: April 29, 2004
    Publication date: December 30, 2004
    Inventors: Patrick L. Iversen, Hong M. Moulton, Michelle H. Nelson, Andrew D. Kroeker, David A. Stein