Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z, Q, W, m, u, ring (A), R2, R3, R4, R5 and R6, are as defined in the specification and claims. The present invention provides a pharmaceutical composition containing the compounds of Formula (I) and a therapeutic method of treating and/or preventing Downs syndrome, 3-amyloid angiopathy, disorders associated with cognitive impairment, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegenerative diseases, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, Alzheimer's disease and/or Down syndrome, age-related macular degeneration (AMD), glaucoma, olfactory function impairment, traumatic brain injury, progressive muscle diseases, Type II diabetes mellitus and cardiovascular diseases (stroke).

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: This document provides systems and methods for testing of various kinds of valves. For example, this document provides systems and methods for accelerated life testing of prosthetic heart valves.

Abstract: The present invention relates to compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein X, Y, Z, Q, W, m, u, ring (A), R2, R3, R4, R5 and R6, are as defined in the specification and claims. The present invention provides a pharmaceutical composition containing the compounds of Formula (I) and a therapeutic method of treating and/or preventing Downs syndrome, ?-amyloid angiopathy, disorders associated with cognitive impairment, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegenerative diseases, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, Alzheimer's disease and/or Down syndrome, age-related macular degeneration (AMD), glaucoma, olfactory function impairment, traumatic brain injury, progressive muscle diseases, Type II diabetes mellitus and cardiovascular diseases (stroke).

Abstract: In a mechanical test system, a method of compensating for acceleration induced load error in a load sensor in a mechanical communication with a component comprises measuring an acceleration of the component to obtain an acceleration measurement. A load sensor measures a force applied by the mechanical test system to a test sample in substantially a same direction of the acceleration to obtain a force measurement. The force measurement is modified with a transfer function that includes at least one of a gain correction and a phase correction to compensate for an error value in the force measurement attributed to movement of at least the load sensor when the force is applied to the test sample.

Abstract: This document provides systems and methods for testing of various kinds of valves. For example, this document provides systems and methods for accelerated life testing of prosthetic heart valves.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: This document provides systems and methods for testing of various kinds of valves. For example, this document provides systems and methods for accelerated life testing of prosthetic heart valves.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variablesRA, RAA, subscipt n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: Stability of a control system for a materials testing system using specified filter parameters is confirmed by inputting to the control system a test signal having a predetermined waveform, automatically monitoring the output of the materials testing system, and automatically comparing the output to a threshold. If the output exceeds the threshold, a first action is taken. If the output does not exceed the threshold, input of a command signal to the control system is permitted.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: A method of controlling a system using a hybrid feedback signal includes providing an input signal with a predetermined waveform to the system and measuring an output of the system with a sensor. An output signal of the sensor is used in a first frequency band as a first portion of a feedback signal. A simulated signal is created in a second frequency band that has one or more of substantially reduced (i) resonances, (ii) phase delay and (iii) noise when compared to the output signal of the sensor in the second frequency band. The simulated signal is used in the second frequency band as a second portion of the feedback signal.

Abstract: The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: In a mechanical test system, a method of compensating for acceleration induced load error in a load sensor in a mechanical communication with a component comprises measuring an acceleration of the component to obtain an acceleration measurement. A load sensor measures a force applied by the mechanical test system to a test sample in substantially a same direction of the acceleration to obtain a force measurement. The force measurement is modified with a transfer function that includes at least one of a gain correction and a phase correction to compensate for an error value in the force measurement attributed to movement of at least the load sensor when the force is applied to the test sample.

Abstract: In a mechanical test system, a method of compensating for acceleration induced load error in a load sensor in a mechanical communication with a component comprises measuring an acceleration of the component to obtain an acceleration measurement. A load sensor measures a force applied by the mechanical test system to a test sample in substantially a same direction of the acceleration to obtain a force measurement. The force measurement is modified with a transfer function that includes at least one of a gain correction and a phase correction to compensate for an error value in the force measurement attributed to movement of at least the load sensor when the force is applied to the test sample.

Abstract: This document provides systems and methods for testing of various kinds of valves. For example, this document provides systems and methods for accelerated life testing of prosthetic heart valves.

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.

Abstract: In a mechanical test system, a method of compensating for acceleration induced load error in a load sensor in a mechanical communication with a component comprises measuring an acceleration of the component to obtain an acceleration measurement. A load sensor measures a force applied by the mechanical test system to a test sample in substantially a same direction of the acceleration to obtain a force measurement. The force measurement is modified with a transfer function that includes at least one of a gain correction and a phase correction to compensate for an error value in the force measurement attributed to movement of at least the load sensor when the force is applied to the test sample.