Patents by Inventor Andrew David Batcho

Andrew David Batcho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D3 analogs
    Patent number: 6452028
    Abstract: A compound of the formula wherein R is hydrogen or hydroxy, each R1 is ethyl, propyl, butyl, isopropyl or t-butyl, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—. These compounds are useful for the treatment of hyperproliferative disorders, skin diseases, and sebaceous gland diseases.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: September 17, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Vitamin D3 analogs
    Patent number: 6331642
    Abstract: Compounds of the formula wherein R1 is hydrogen or an alkyl group; R2 is hydrogen or an alkyl group; or R1, R2 and C20 together are cyclopropyl; R3 is alkyl, hydroxy-alkyl or fluoroalkyl; and R4 is alkyl, hydroxy-alkyl or fluoroalkyl which are useful in the treatment of breast cancer, prostate cancer, myeloid leukemia benign prostate growth, baldness and osteoporosis.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: December 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Milan Radoje Uskokovic
  • Vitamin D3 analogs
    Patent number: 6329538
    Abstract: A compound of the formula wherein R is hydrogen or hydroxy, each R2 is independently H or halogen, X is ═CH2, or when R is hydroxy, X is hydrogen or ═CH2, and A is —C≡C—, or —CH2—CH2—, provided that when A is —CH2—CH2—, R2 is H.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: December 11, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Synthesis of 3-epi vitamin D.sub.3 metabolites and analogs
    Patent number: 6040461
    Abstract: The invention relates to a process for the preparation of vitamin D.sub.3 compounds of formula I. ##STR1## Wherein A is a single or a double bond; B is a single, cis-double, trans double or a triple bond; R.sub.1 and R.sub.2 are independently hydrogen, a lower alkyl, e.g., a C.sub.1 -C.sub.4 alkyl; R.sub.3 and R.sub.4 are independently a lower alkyl, e.g., C.sub.1 -C.sub.4 alkyl, a hydroxyalkyl, and a haloalkyl, e.g., a fluoroalkyl; and X and Y are independently hydrogen or hydroxy in the case when B is a single or a double bond.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: March 21, 2000
    Assignees: Hoffmann-La Roche Inc., Syntex (U.S.A.)
    Inventors: Andrew David Batcho, Percy Sarwood Manchand, Milan Radoje Uskokovic
  • Vitamin D.sub.3 analogs
    Patent number: 5939408
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, fluorine, or hydroxyl, each R.sub.2 is lower alkyl or C(R.sub.3).sub.3 and R.sub.3 is halogen, X is .dbd.CH.sub.2 or when R is hydroxy, X is hydrogen or .dbd.CH.sub.2, and A is --C.tbd.C-- ##STR2## or --CH.sub.2 --CH.sub.2 --, which are useful in the treatment of hyperproliferative skin disorders, neoplastic diseases, and sebaceous gland diseases.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: August 17, 1999
    Assignee: Hoffman-La Roche Inc.
    Inventors: Andrew David Batcho, Bernard Michael Hennessy, Jerome Anthony Iacobelli, Milan Radoje Uskokovic
  • Synthesis of tryptophans
    Patent number: 4073795
    Abstract: The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.
    Type: Grant
    Filed: June 22, 1976
    Date of Patent: February 14, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Urs Oskar Hengartner, Willy Leimgruber, John William Scott, Donald Valentine, Jr.
  • Intermediates for indoles
    Patent number: 3976639
    Abstract: Ortho-nitrotoluenes are condensed with formamide acetals to yield the corresponding otho-nitro-.beta.-aminestyrenes which undergo cyclization upon reduction to yield indoles.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: August 24, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Andrew David Batcho, Willy Leimgruber