Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: Some embodiments relate to non-woven composite materials, methods of making and uses thereof, including articles including the composite structures. More particularly, some embodiments relates to non-woven composite materials possessing desirable impact performance and penetration resistance.

Abstract: An input device includes a control surface for a color correction system. The control surface includes a housing with an upwardly facing control panel. The control panel has a proximal edge which is nearest a user and a distal edge that is furthest from a user in normal use. The control panel includes a plurality of controls. The plurality of controls includes: a plurality of trackballs, wherein each trackball comprises a ball and a control ring, said ball cooperating with at least one encoder to generate a multi-dimensional control signal based on motion of the ball, and said control ring cooperating with at least one encoder to generate a one dimensional control signal based on the rotational motion of the ring, wherein the ball of said trackball is mounted concentrically with said control ring; a plurality of control buttons; and a plurality of knobs coupled to respective rotary encoders.

Abstract: Thermal control system for aircraft main landing gear wheel wells and related methods are disclosed. An example thermal control system includes a conduit defining a fluid passageway between an inlet and an outlet. The inlet of the conduit positioned in fluid communication with a landing gear wheel well and the outlet of the conduit positioned in fluid communication with the atmosphere. The conduit generates a pressure differential through the fluid passageway between the inlet and the outlet to exhaust heat from the landing gear wheel well to the atmosphere.

Abstract: An example device for repairing a tissue is described herein. The device can include a flexible carrier layer, and a support member including a plurality of micro-protrusions extending therefrom. The support member can be at least partially integrated with the flexible carrier layer. Additionally, the flexible carrier layer can be configured to cover at least a portion of the tissue, and the micro-protrusions can be configured to mechanically interface with the tissue.

Abstract: Apparatus and associated methods relate to using a plurality of antennas radially distributed about a rotatable turret to sequentially scan a field of view. Each of the plurality of antennas directs an electromagnetic beam and senses its reflection along a principal direction defined by a roll position of the rotatable turret and an azimuthal beam angle. The principal directions of the antennas have a unique azimuthal beam angle relative to a boresight (i.e., axis of rotation). As the turret rotates, each of these antennas is sequentially turned on at a first roll position and off at a second roll position. This enables electromagnetic beams generated by the antennas to pan a scene both in azimuth and roll. An image processor then determines, based on the reflected signals received by the plurality of antennas, directions to and/or velocities of objects within the scanned field of view.

Abstract: The following relates generally to voice assisted delivery of goods. In some embodiments, a digital assistant receives audio data, and determines an intent from the audio data. The digital assistant may then match the determined intent to a flow of a set of flows, where the set of flows may include at least one of: (i) requesting curbside pickup of an item, (ii) requesting locker storage of the item, (iii) requesting an indication of locations that the item is available, (iv) requesting an indication of an inventory of a retail store, (v) requesting ads for an additional item that is related to the item, (vi) requesting a status of an order for the item, (vii) requesting drone delivery of the item from a retail store to a residence, or (viii) requesting drone delivery of the item from a warehouse to the residence. The matched flow of the set of flows may then be executed.

Abstract: Methods and systems for generating physiological metrics for display on a computing device are disclosed herein. In some implementations, an exemplary system comprises a torso wearable device including a wireless transmitter and a sensor, and non-transitory computer-readable media (CRM). The CRM, when executed by a computing device in communication with the wireless transmitter, can perform operations comprising: receiving the input signals representing respiration of the user; displaying a graphical user interface to the user; receiving one or more user inputs associated with a desired metric; displaying on the graphical user interface a first visualization corresponding to the desired metric; and displaying on the graphical user interface a second visualization corresponding to a physiological metric based on the input signals generated from the sensor. The second visualization can change in real time based on real time angular displacement of the sensor in response to the respiration of the user.

Abstract: Techniques are described for backlighting electronic headset display panels. The backlight can include a light guide plate that is illuminated via a light transmitting element that is coupled to a light source. The light guide plate, in turn, illuminates the display panel. The light source is located within the headset but is disposed remotely from the display panels. A photodiode is coupled to a surface of the light transmitting element and is configured to detect a characteristic of the light transmitted by the light transmitting element.

Abstract: Breathing assistance apparatus includes a gases supply unit adapted to, in use, deliver a stream of pressurised gases from an outlet. The gases supply unit is adapted to vary the pressure of the stream of pressurised gases. A supply path includes a flexible self-supporting gases transportation pathway having a first end connected to the outlet so that the gases transportation pathway receives the stream of gases and conveys the gases to a patient. A patient interface is connected to the second end of the gases transportation pathway receives a stream of gases. At least one sensor measures at least one information parameter of the supply path. A control system associated with the gases supply unit receives the information parameter. The control system contains reference data, and compares the received data to reference data, and determines a supply path based on the comparison.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Embodiments herein describe spectroscopy systems that use an unmodulated reference optical signal to mitigate noise, or for other advantages. In one embodiment, the unmodulated reference optical signal is transmitted through the same vapor cell as a modulated pump optical signal. As such, the unmodulated reference optical signal experiences absorption by the vapor, which converts laser phase noise to amplitude noise like the other optical signals passing through the vapor cell. In one embodiment, the unmodulated reference optical signal has an optical path in the gas cell that is offset (or non-crossing) from the optical path of the modulated pump optical signal. The unmodulated reference optical signal allows removal or mitigation of the noise on the other optical signal.

Abstract: The present invention provides a method for preparing a colour-stable preparation of a magnesium chlorophyllin alkali metal salt or alkali earth metal salt from natural sources of chlorophyll. The invention further provides a colour-stable and substantially pure pigment composition comprising a vibrant green magnesium chlorophyllin in the form of an alkali metal or alkali earth metal salt, e.g. those prepared by the methods of the invention, and the use of the salts and compositions of the invention as colouring agents, in particular as food colouring agents, and as medicaments and disinfectants.

Abstract: The invention relates to a set of oligonucleotides, and a kit comprising a set of oligonucleotides where the oligonucleotides are for use in determining the HLA genotype of a DNA sample. The invention also relates to a method of determining the HLA genotype of a DNA sample. The method may be used to identify a suitable donor and/or recipient of a transplant, for paternity testing, to identify the HLA type for determination of epitope binding capability in neo-antigen prediction, or for diagnosing an immune disorder such as ankylosing spondylitis. The method preferably uses long-range PCR and long read sequencing preferably using a Type R10 nanopore.

Abstract: A pushcart consisting of a folded and unfolded body frame and a storage bag enveloped on the body frame, whereas the body frame, including rigid left frame and right frame, and hinges that link left and right frames, front and rear ends, which form the whole body with left and right frames that can collide and be folded and unfolded, and the upper mouth and bottom of the bag can be opened by unfolded left and right frames.

Abstract: A cervical traction assembly for use with a patient support apparatus includes an adjustment carriage track member including a connecting bracket assembly that releasably connects to a mount support member of the patient support apparatus. The adjustment track member includes a track body including a pair of opposing sidewalls that are spaced-apart from each other to define an elongated channel therebetween. Each sidewall includes a guide track that extends along a length of the respective sidewall. A rope angle adjustment carriage is located within the channel. The rope angle adjustment carriage includes a first track engagement member that is received by one of the guide tracks of one of the sidewalls and a second track engagement member that is received by another of the guide tracks of another of the sidewalls. The first track engagement member has a locked configuration that inhibits movement of the rope angle adjustment carriage.

Abstract: Thermocouples for high temperature applications are provided. A thermocouple includes a vessel formed from a dielectric material, the vessel defining a first chamber and a second chamber, the first chamber and second chamber in fluid communication. The thermocouple further includes a first thermoelement disposed in the first chamber, the first thermoelement formed from a first thermoelectric material. The thermocouple further includes a second thermoelement disposed in the second chamber, the second thermoelement formed from a second thermoelectric material different from the first thermoelectric material, and wherein the second thermoelement is a liquid at operating conditions of the thermocouple.