Abstract: A device for dispensing a hydrofluoroolefin vapocoolant composition as an aerosol is disclosed. The device comprises an aerosol-dispensing container comprising an internal chamber, a valve, a dispensing hole, and an actuator. The device also comprises a hydrofluoroolefin vapocoolant composition comprising HCFO-1233zd at 70% to 100% (weight/weight) and, optionally, HFO-1234ze in at 0% to 30% (weight/weight). The hydrofluoroolefin vapocoolant composition is stored within the internal chamber. The aerosol-dispensing container is configured so that depressing the actuator reversibly opens the valve to allow the hydrofluoroolefin vapocoolant composition to flow from the internal chamber, past the valve, and through the dispensing hole, thereby dispensing the hydrofluoroolefin vapocoolant composition from the aerosol-dispensing container. A method of treating pain and/or swelling of a tissue of a patient by use of the device also is disclosed.

Abstract: The present invention generally relates to introducing genetic material to living cells. In some embodiments, the present invention relates to compositions of matter for targeted delivery of nucleic acids to cells. In other embodiments, the present invention relates to methods of targeted delivery of nucleic acids to cells. In still other embodiments, the present invention relates to polymers that contain at least one amino acid in their backbone. In yet other embodiments, the present invention relates to polymers that contain at least one amino acid in their backbone thereby resulting in biodegradability, and in some embodiments, controlled biodegradability.