Abstract: The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: The present invention provides for compounds of Formula (I) wherein A, L, W, and R1 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL, SLL, and/or ALL.

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

Abstract: Circuits are provided that create entanglement among qubits having Gottesman-Kitaev-Preskill (GKP) encoding using photonic systems and structures. For example, networks of beam splitters and homodyne measurement circuits can be used to perform projective entangling measurements on GKP qubits from different quantum systems. In some embodiments. GKP qubits can be used to implement quantum computations using fusion-based quantum computing or other fault-tolerant quantum computing approaches.

Abstract: A closed-loop perfusion system may include a sealed biological culture container configured to house a biological cell culture, and a filtering unit that permits passage of waste products from an output of the sealed biological cell culture container, permits passage of nutrients from a nutrient media solution, and blocks passage of beneficial molecules from the output of the sealed biological cell culture container. The system may further include a first fluid path between an output of the sealed biological cell culture container and an input of the filtering unit, a second fluid path between an output of the filtering unit and an input of the sealed biological cell culture, and a pump to control the flow of media through the first fluid path and the second fluid path.

Abstract: An electronic healthcare data de-identification system can accept data containing personally-identifiable information and output de-identified healthcare data that is uniquely identifiable and has preserved temporal order. The unique identity of the de-identified healthcare data is preserved with universally unique identifiers and the temporal order of the de-identified healthcare data is maintained with universally unique sequence values that synchronize the timing of healthcare events. The embodiments described herein make healthcare data more accessible to users without endangering their privacy and allow conclusions to be made from large sets of data without restricting its use due to privacy concerns. Other embodiments are also described.

Abstract: The isolation of the tyrB gene contained in E. coli ATCC 11303 and its cloning onto a multicopy plasmid results in a 10-fold increase in the L-phenylalanine yield after the transformation of the starting strain with this plasmid.