Abstract: This invention is in the area of improved combination treatments for a select group of hard-to-treat cancer patients, including, for example, those with advanced/metastatic triple negative breast cancer (TNBC), recurrent or metastatic urothelial cancer (mUC), or a Trop-2 overexpressing cancer such as non-small cell lung cancer (NSCLC), wherein the improved combination includes the use of trilaciclib and sacituzumab govitecan, and provides increased overall survival and/or reduced toxicity.

Abstract: Antibody molecule-drug conjugates (ADCs) that specifically bind to lipopolysaccharides (LPS) are disclosed. The antibody molecule-drug conjugates can be used to treat, prevent, and/or diagnose bacterial infections and related disorders.

Abstract: Exemplified methods and systems facilitate presentation of data derived from measurements of the heart in a non-invasive procedure (e.g., via phase space tomography analysis). In particular, the exemplified methods and systems facilitate presentation of such measurements in a graphical user interface, or “GUI” (e.g., associated with a healthcare provider web portal to be used by physicians, researchers, or patients, and etc.) and/or in a report for diagnosis of heart pathologies and disease. The presentation facilitates a unified and intuitive visualization that includes three-dimensional visualizations and two-dimensional visualizations that are concurrently presented within a single interactive interface and/or report.

Abstract: An automated system and method for assisting in decision making for the treatment of stroke patients is provided, and specifically for assisting a physician whether the patient should be administered a drug or transferred to another hospital to undergo an endovascular thrombectomy procedure. A variety of factors are input into the system with limited human intervention and a tool automatically determines the probability of whether the patient will have a better outcome if transferred or not. The factors include clinical factors, imaging factors and time to transfer factors. The tool includes processes for automatically determining several imaging factors, including the determination of clot length, collateral blood flow, the presence of forward blood flow within and around the clot, and the clot permeability. The tool has capability to continuously update the treatment protocol and other output results using current clinical, health system or other relevant information or feedback.

Abstract: A gas turbine engine including: a fan assembly comprising a fan; and a turbomachine drivingly coupled to the fan and including a compressor section, a combustion section, and a turbine section arranged in serial flow order and defining in part a working gas flowpath, the gas turbine engine defining a bypass passage over the turbomachine; the turbomachine further including a heat exchanger and defining an annular cooling passage extending between an inlet and an outlet, the inlet in airflow communication with the working gas flowpath at a location upstream of the compressor section and the outlet in airflow communication with the bypass passage, the heat exchanger in thermal communication with an airflow through the cooling passage.

Abstract: Systems, computer program products, and methods are described herein for intrusion detection using resource activity analysis. The present invention is configured to receive, from a computing device of a user, an indication that the user has accessed a resource allocation portfolio of a customer; determine a geographic information of the user; retrieve a geographic information of the customer; determine that the geographic information of the user does not match the geographic information of the customer; determine an exposure level associated with the user access of the resource allocation portfolio of the customer; determine that the exposure level is greater than a predetermined threshold; and automatically trigger a transmission of a notification to a computing device of an administrator indicating that the exposure level associated with the user access of the resource allocation portfolio of the customer is greater than the predetermined threshold.

Abstract: Aspects of the present invention relate to user interface control of a head-worn computer.

Abstract: An online document system manages access to features within the online document system. The online document system may identify a first entity and a second entity associated with the first entity. The online document system may apply a trained machine learning model to a characteristic of at least one of the first entity or the second entity to identify one or more features within an online document system to recommend. The machine learning model may have been trained using feature training data describing one or more characteristics of a plurality of entities and describing historical activity associated with a usage of a plurality of features within the online document system by the plurality of entities. The online document system may output an indication of the one or more identified features to the first entity.

Abstract: One or more techniques and/or systems are disclosed for air seeding using an agricultural seeder. The agricultural seeder includes an air seeder for an agricultural implement having a frame, a plurality of seeding units coupled to the frame, and a linkage coupling an arm to the frame, wherein the arm is coupled to a ground engaging member. The air seeder further includes an actuator having a piston and cylinder arrangement operationally coupled to the arm and configured to adjust a ground penetration depth of the ground engaging member. The piston and cylinder arrangement include a two-stage cylinder operable to change a height of the ground engaging member by movement of the two-stage cylinder to adjust the ground penetration depth of the ground engaging member.

Abstract: An online document system provides a recommendation for one or more features within the online document system to an entity. The online document system accesses a set of feature training data to train a machine learning model. The set of feature training data may describe characteristics of entities associated with the online document system and historical activity associated with the entities' usage of the online document system's features. The machine learning model may be configured to identify a feature to recommend to an entity based on the entity's characteristics and history of using other features within the online document system. For example, data representing the entity's user accounts and use of an electronic signature feature is used by the machine learning model to identify a document authentication feature to recommend to the entity. The online document system may then provide the identified feature in a recommendation to the entity.

Abstract: A thermal component has a shield portion and a heat exchanger portion. The shield portion includes a plurality of cells adapted to inhibit radio radiation (RF) having a frequency within a target frequency range, while the heat exchanger portion includes a plurality of elongated channels, each one of the elongated channels being physically connected to and in fluid communication with at least one corresponding cell of the plurality of cells.

Abstract: A blade for a turbine engine with a wall separating a cooling fluid flow and a hot gas fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow. A plurality of cooling holes each having a passage extending between an inlet at the cooled surface and an outlet at the heated surface. The outlet extending between an upstream end and a downstream end with respect to the hot gas fluid flow to define a distance, the passage defining a centerline forming a first angle (?) with the heated surface.

Abstract: In a handheld communication device capable of a plurality of wireless communication modes, a method of communication begins by receiving, at the handheld communication device, a notification of an available one of the wireless communication modes. Then, in a data communication window of the communication device, a user-indication of an active one of the available wireless communication modes is provided in accordance with the received communication mode indication. The data communication window is configured to facilitate data communication via the plurality of wireless communication modes, and facilitates the data communication via the active wireless communication mode.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A method of composing an email message at an electronic device and an electronic device operable to carry out the method are provided. The method includes receiving an email command from a user input of the electronic device through a calendar user interface, the email command relating to at least one of a plurality of intended attendees of a calendared meeting, and providing an email composition interface in response to receiving the email command. The email composition interface includes a user-editable portion of an address field. The user-editable portion of the address field is automatically populated with email address information for the at least one of the plurality of intended attendees.

Abstract: In a hybrid computing system including at least one analog processor and at least one digital processor an embedded problem is repeatedly run or executed on the analog processor(s) to generate a first plurality of candidate solutions to the computational problem, the candidate solutions are returned to the digital processor(s) which determine a value for at least one statistical feature of the candidate solutions, at least one programmable parameter of the plurality of analog devices in the analog processor(s) is adjusted to at least partially compensate for deviations from an expected value of the at least one statistical feature, the expected value of the at least one statistical feature inferred from the structure of the embedded problem, the embedded problem is again repeatedly run or executed on the analog processor(s) to generate a second plurality of candidate solutions to the computational problem.

Abstract: A paving support system comprising flooring support members (100) having upturned tabs for spacing apart flooring members such as paving slabs.

Abstract: A computational method via a hybrid processor comprising an analog processor and a digital processor includes determining a first classical spin configuration via the digital processor, determining preparatory biases toward the first classical spin configuration, programming an Ising problem and the preparatory biases in the analog processor via the digital processor, evolving the analog processor in a first direction, latching the state of the analog processor for a first dwell time, programming the analog processor to remove the preparatory biases via the digital processor, determining a tunneling energy via the digital processor, determining a second dwell time via the digital processor, evolving the analog processor in a second direction until the analog processor reaches the tunneling energy, and evolving the analog processor in the first direction until the analog processor reaches a second classical spin configuration.

Abstract: Systems and methods for document generation are provided. One aspect of the systems and methods includes identifying, by a style extractor, a document fragment comprising a first style element of a first style category; computing, by a style generator, a reward function based on a correlation value between the first style element and a second style element of a second style category different from the first style category, wherein the correlation value is based on correlations between style elements in a plurality of historical document fragments; selecting, by the style generator, the second style element based on the reward function; and generating, by a document generator, a modified document fragment that includes the first style element of the first style category and the second style element of the second style category.

Abstract: Pet owners are frustrated with conventional wet pet food packages as it is difficult to remove product from these packages. Traditional metal or plastic containers and flexible pouches are not designed to fully eject product in one step. Rather, the consumer must perform additional steps such as scooping, scraping, tearing, or twisting to entirely remove product. Provided is a collapsible package for wet pet foods. The collapsible package has tapered flexible sidewall, a rigid ring and/or circumferential peripheral flange attached to a top of the sidewall, and a rigid base attached to a bottom of the sidewall. The flexible sidewall is configured to be compressible between an expanded position, at which point product is held in the container, and a collapsed position, at which point product is effectively ejected from the container. A lid can also be attached to the ring and/or circumferential peripheral flange to seal the container.