Abstract: The present application is directed to sulfur-functionalized monoliths and particles derived therefrom as nitric oxide (NO) carriers for applications in drug delivery and cosmetic formulations. An example aspect of the application includes a monolith structure which contains a first monomer having a sulfur functionalized side group linked with a second monomer to form a framework. Another aspect of the application includes a particle having a rough surface derived from the monolith. A further aspect of the application includes the particle having a rough surface which has been reacted to form a nitrosylated particle containing NO covalently attached to a sulfur group. As also described in the application, aspects of the disclosure can include methods for making the monolith structure, methods for deriving a particle or particle having a rough surface from the monolith, and methods for treating a condition using a nitrosylated particle or a particle loaded with NO.

Abstract: Disclosed herein is a delivery platform for the preparation of versatile sol-gel/hydrogel based nano and micro particles that can be loaded with small molecules. The delivery platform is suitable for topical, transdermal, IV, IP and aerosol drug delivery. Also disclosed herein are methods of treatment using the aforementioned particles.

Abstract: The present disclosure is directed to systems and methods for delivery of nitric oxide (NO). The methods and systems disclosed herein may provide advantages by controlling NO generation until desired by an end user. To achieve controlled NO generation, embodiments of the disclosure can include multiple compositions that may be in the form of a kit or a multi-chamber delivery system. Additionally, the disclosure contemplates the use of these systems as methods for generating NO by mixing the multiple compositions to yield the controlled generation and/or release of NO. Methods of the disclosure can be used for the controlled delivery of NO to a biological surface (e.g., the skin) and may be used to treat a condition or disease.

Abstract: Disclosed herein is a process for making a dried meat snack and the product produced by said process.

Abstract: A snack food incorporating various ingredients of chicken noodle soup is described. The processing of a chicken noodle soup mixture begins with three separate batch operations (e.g., pasta, chicken/vegetable filling, and broth) that are completed before moving to a continuous forming process, such as a triple cold forming extrusion operation. Extrusion typically begins with a machine kneading and then forming a pasta shell under high pressure through a custom die. Concurrently, the chicken/vegetable filling and broth move through the extruder in separate streams allowing for two distinct fillings one inside the other (e.g., broth inside chicken), filling approximately 75% of the pasta shell's volume allowing room for closing. The product is simultaneously cut and sealed at a suitable length.