Abstract: A drug delivery device includes a housing, a container at least partially disposed within the housing and configured to contain a medicament, an injection mechanism at least partially disposed within the housing and configured to exert a force to urge the medicament from the container, a drug delivery component at least partially disposed within the housing, and at least one pin positioned adjacent to the housing and preventing activation of the activation mechanism until the at least one pin reaches a desired temperature.

Abstract: A computing platform is configured to (i) receive data objects related to a construction project, (ii) add the data objects to a construction knowledge graph as nodes that are connected to other nodes representing other data objects, (iii) determine, via a machine-learning model trained using historic construction project data, a first risk score for a first data object, (iv) determine, via the machine-learning model, a second risk score for a second data object, where the second risk score is based on (a) the first risk score and (b) a degree of separation between the first data object and the second data object in the construction knowledge graph, (v) based on the second risk score, automatically generate a suggested action to be taken with respect to the first data object, and (vi) cause an indication of the suggested action to be displayed at a client station of a user associated with the construction project.

Abstract: A system and method for visualizing blood flow are disclosed. The method generally includes obtaining a laser speckle contrast imaging (LSCI) image of blood flow; obtaining a white light image of a tissue, the white light image capturing an anatomical structure of a subject in a region associated with the LSCI image of the blood flow; spatially registering the LSCI image and the white light image with one another; overlaying the spatially registered LSCI and white light images; and generating display data which includes the spatially registered LSCI and white light images and that continuously depicts the blood flow overlaying the tissue.

Abstract: Disclosed herein are methods of transferring exogenous material using platelets. The methods comprise administering the platelets with the exogenous material to a recipient. The platelets may be obtained by directly contacting the platelets, or contacting megakaryocytes that produce the platelets.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: A flow control system and method of detecting a condition of a pump set mounted on the apparatus. The system configured to perform the method of advancing a first amount of the feeding formula through the feeding pump via a feeding formula conduit. Further, the system may acquire a first pressure sensor reading of the feeding formula conduit. Further, the system may advance a second amount of the feeding formula through the feeding pump via the feeding formula conduit, wherein the second amount is second volume of the liquid. Further, the system may acquire a second pressure sensor reading of the feeding formula conduit, and acquire a third pressure sensor reading of the feeding formula conduit. Further, the system may detect an occlusion in the feeding formula conduit based on at least one of the first pressure sensor reading, the second pressure sensor reading and the third pressure sensor reading.

Abstract: A computing platform is configured to (i) receive data objects related to a construction project, (ii) add the data objects to a construction knowledge graph as nodes that are connected to other nodes representing other data objects, (iii) determine, via a machine-learning model trained using historic construction project data, a first risk score for a first data object, (iv) determine, via the machine-learning model, a second risk score for a second data object, where the second risk score is based on (a) the first risk score and (b) a degree of separation between the first data object and the second data object in the construction knowledge graph, (v) based on the second risk score, automatically generate a suggested action to be taken with respect to the first data object, and (vi) cause an indication of the suggested action to be displayed at a client station of a user associated with the construction project.

Abstract: A drug delivery device includes a housing, a container at least partially disposed within the housing and configured to contain a medicament, an injection mechanism at least partially disposed within the housing and configured to exert a force to urge the medicament from the container, a drug delivery component at least partially disposed within the housing, and at least one pin positioned adjacent to the housing and preventing activation of the activation mechanism until the at least one pin reaches a desired temperature.

Abstract: Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.

Abstract: Existing single cell analysis techniques are generally high-resolution but are limited in the number of possible different experimental conditions. Disclosed herein are compositions and methods for multiplexed barcoding of a heterogenous population of cells using cationic polymers for delivery of nucleic acid barcodes to a cell population.

Abstract: The present disclosure provides a system and method for locating terminals within a facility. One or more of a plurality of primary terminals send a location signal which may comprise location data for the respective primary terminal. A secondary terminal, of a plurality of secondary terminals may receive one or more of these location signals. In response, the secondary terminal sends a confirmation message to each primary terminal from which it has received a location signal. The confirmation message may comprise a unique identifier for the secondary terminal. In response to receiving one or more confirmation messages, a primary terminal sends a location reporting message to a location processing server. The location reporting message comprises the location data for that primary terminal and the contents of the received confirmation message(s). The data held on the location processing server can be used to determine the location and movement of each of the primary terminals and the secondary terminals.

Abstract: The present disclosure provides a system and method for locating terminals within a facility. One or more of a plurality of primary terminals send a location signal which may comprise location data for the respective primary terminal. A secondary terminal, of a plurality of secondary terminals may receive one or more of these location signals. In response, the secondary terminal sends a confirmation message to each primary terminal from which it has received a location signal. The confirmation message may comprise a unique identifier for the secondary terminal. In response to receiving one or more confirmation messages, a primary terminal sends a location reporting message to a location processing server. The location reporting message comprises the location data for that primary terminal and the contents of the received confirmation message(s). The data held on the location processing server can be used to determine the location and movement of each of the primary terminals and the secondary terminals.

Abstract: Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.

Abstract: In various embodiments, a drug pump includes a housing and, within the housing, an expandable drug reservoir at least part of which is exposed to a pressurized propellant. The propellant exerts a substantially constant pressure on the drug reservoir. A flow restrictor significantly limits outflow from the pump, and preferably has both a small diameter and a long path length, which acts to control the outflow from the drug reservoir. As a result, the pump produces a substantially constant outflow.

Abstract: Embodiments of the present invention provide a vent arrangement integrated with a refill port disposed on the outer shell of an implantable drug-delivery device. The vent arrangement may utilize a tiered structure with two septums in a space-efficient configuration that facilitates both venting of pressure and refill of the drug reservoir.

Abstract: Embodiments of the present invention involve a refill apparatus comprising at least one pump, a plurality of reservoirs, a plurality of reservoir fluid channels each associated with one of the reservoirs, a plurality of valves, each having a cracking pressure, for fluidically sealing the reservoir fluid channels and the outlet fluid channel, an outlet fluid channel fluidically connected to the reservoir fluid channels, and a needle having a lumen in fluid communication with the outlet fluid channel. A parameter such as a pressure level is monitored, and one or more pumps and various ones of the valves are actuated in accordance with a protocol comprising a sequence of steps whereby fluidic pathways are opened between different ones of the reservoirs and the needle in a washing and filling sequence, each of the steps being associated with an expected pressure level.

Abstract: Tubular polymeric structures are formed by creating a convex mold conforming to a fluid pathway design, depositing a coating of polymer over the mold, and in situ removing the mold without drawing it against the polymer. The resulting structures are fabricated with flow-altering features.

Abstract: In various embodiments, approaches to calibrating an implantable drug-delivery device feature a drug reservoir, an expandable electrolysis chamber, and an integrated strain gauge using a refill apparatus having one or more pumps, one or more refill reservoirs, an outlet fluid channel fluidically connected to the refill reservoir(s), and a needle having a lumen in fluid communication with the outlet fluid channel include inserting a needle into a refill port of the implantable drug-delivery device, monitoring a pressure change within the device, monitoring a pressure level of one or more components of the implantable drug-delivery device, and calibrating the monitored pressure level of the component(s) of the implantable drug-delivery device to the monitored pressure level of the outlet fluid channel.

Abstract: Systems and methods for particle tracking using spatiotemporal offset light beams. In exemplary embodiments, the optical systems and methods can be used with conventional two-photon microscopy equipment to perform high speed, high precision, and deep tissue three-dimensional single-particle tracking. Exemplary embodiments can be configured for single-molecule studies of biological diffusion and transport processes.