Abstract: The present disclosure provides a method of treating a central nervous system disorder in a patient in need thereof. The method comprises orally administering between 75 mg and 300 mg xanomeline salt and between 20 mg and 200 mg trospium chloride to the patient during a 24-hour period, the central nervous system disorder being selected from schizophrenia, Alzheimer's disease, Huntington's disease, Parkinson's disease, and Lewy Body dementia, wherein use of the trospium chloride alleviates a side effect associated with use of the xanomeline salt.

Abstract: A liquid fuel pumping apparatus of the rotary distributor type has an electromagnetically operable spill control valve including a valve member which is closed to prevent spillage of fuel from the high pressure pump of the apparatus. A transducer including a core member and a winding is provided to provide signals from which it is possible to determine the instants of spill valve closure and opening. The signals are used in a control system to control the operation of the apparatus.

Abstract: A liquid fuel pumping apparatus for supplying fuel to a multi-cylinder engine has a plurality of outlets for connection to the injection nozzles of the engine. The apparatus includes a spill passage and a spill control valve which is electrically controlled. The valve is closed to cause fuel from a high pressure pump to be delivered through the outlets, fuel being supplied by the high pressure pump to the outlets in turn. A pressure transducer provides signals indicative of the pressures attained in the various outlets during delivery of fuel therethrough. One of the pressure signals serves as a standard and the other signals are compared with this signal to produce correction signals which vary the time the spill valve is closed when fuel is supplied to those outlets to which the other signals pertain.