Patents by Inventor Andrew E. Sama

Andrew E. Sama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SAA-domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
    Patent number: 10183971
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: January 22, 2019
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • SAA-DOMAIN-SPECIFIC ANTIBODIES AND PEPTIDE ANTAGONISTS AND USE THEREOF TO TREAT INFLAMMATORY DISEASES
    Publication number: 20170029463
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 2, 2017
    Applicant: The Feinstein Institue For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • SAA domain-specific antibodies and peptide antagonists and use thereof to treat inflammatory diseases
    Patent number: 9458232
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 4, 2016
    Assignee: The Feinstein Institute For Medical Research
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • SAA DOMAIN-SPECIFIC ANTIBODIES AND PEPTIDE ANTAGONISTS AND USE THEREOF TO TREAT INFLAMMATORY DISEASES
    Publication number: 20150023957
    Abstract: Isolated SAA peptides, fusion proteins and compositions comprising such are provided as are domain-specific SAA antibodies. Methods of treating sepsis and endotoxemia are also provided.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 22, 2015
    Applicant: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
    Inventors: Haichao Wang, Andrew E. Sama, Wei Li, Kevin J. Tracey
  • Inhibition of inflammatory cytokine production with tanshinones
    Patent number: 8513227
    Abstract: Provided are methods of attenuating release of a proinflammatory cytokine from a mammalian cell. Also provided are methods of inhibiting or treating an inflammatory cytokine cascade in a mammal. Further provided are methods of treating a mammal at risk for or undergoing sepsis, septicemia, and/or endotoxic shock. Additionally provided are methods of attenuating NO release from a mammalian cell. Also provided are methods of attenuating NO production in a mammal at risk for, or having, a disorder mediated by excessive NO production.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: August 20, 2013
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Haichao Wang, Dazhi Chen, Andrew E. Sama
  • Inhibition of Inflammatory Cytokine Production With Tanshinones
    Publication number: 20090221542
    Abstract: Provided are methods of attenuating release of a proinflammatory cytokine from a mammalian cell. Also provided are methods of inhibiting or treating an inflammatory cytokine cascade in a mammal. Further provided are methods of treating a mammal at risk for or undergoing sepsis, septicemia, and/or endotoxic shock. Additionally provided are methods of attenuating NO release from a mammalian cell. Also provided are methods of attenuating NO production in a mammal at risk for, or having, a disorder mediated by excessive NO production.
    Type: Application
    Filed: January 12, 2007
    Publication date: September 3, 2009
    Inventors: Haichao Wang, Dazhi Chen, Andrew E. Sama
  • Inhibition of HMGB1 release by fetuin
    Patent number: 7329643
    Abstract: Methods of inhibiting HMGB1 release by a mammalian cell are provided. The methods comprise treating the cell with sufficient fetuin to inhibit HMGB1 release. Methods of inhibiting an inflammatory cytokine cascade in a mammal are also provided. These methods comprise administering sufficient fetuin to the mammal to inhibit HMGB1 release in the mammal. Also provided are methods of treating a condition in a mammal characterized by an inflammatory cytokine cascade. These methods comprise administering sufficient fetuin to the mammal to inhibit HMGB1 release in the mammal.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: February 12, 2008
    Assignee: The Feinstein Institute for Medical Research
    Inventors: Kevin J. Tracey, Haicho Wang, Andrew E. Sama