Abstract: There is provided a method of driving a shape memory alloy haptic assembly comprising an actuator comprising shape memory alloy that is arranged on actuation to provide a haptic effect, the method comprising supplying drive current to the actuator successively during a pre-heating period in which the temperature of the shape memory alloy is raised without causing the shape memory alloy to provide the haptic effect and during an actuation period in which the temperature of the shape memory alloy is raised so as to cause the shape memory alloy to provide the haptic effect. A shape memory alloy haptic assembly is also provided.

Abstract: The invention relates to a DDX3X inhibitor for use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R1, X, L, Ra and Rb are as defined herein. The invention also relates to compounds of Formula (I).

Abstract: The invention relates to a DDX3X inhibitorfor use in the treatment of pneumovirus infection in a mammal, wherein the DDX3X inhibitor may be a compound of Formula (I) wherein y, Z, R1, X, L, Ra and Rb are as defined herein. The invention also relates to compounds of Formula (I).

Abstract: The invention relates to virology and the prevention and/or treatment of viral infection and disease in animals, including birds and humans. The invention relates to the field of antiviral treatments. The invention further relates to methods of stimulating innate immunity and natural interferon production in humans or animals and in component parts of humans or animals, including cells and tissues. The invention also relates to the field of defective interfering (DI) viruses, including cloned DI viruses.

Abstract: The invention relates to virology and the prevention and/or treatment of viral infection and disease in animals, including birds and humans. The invention relates to the field of antiviral treatments. The invention further relates to methods of stimulating innate immunity and natural interferon production in humans or animals and in component parts of humans or animals, including cells and tissues. The invention also relates to the field of defective interfering (DI) viruses, including cloned DI viruses.

Abstract: The application relates to an assay method for studying the effect of at least one compound on RN virus replication and transcription comprising the steps of providing a synthetic RN molecule encoding at least a portion of the genome of an RN virus of interest and a copy of a reporter gene; incubating a cell containing the RN molecule with the or each compound and detecting an amount of reporter gene product. Preferably the RNA virus is a paramyxovirus such as human respiratory syncytial virus or avian pneumovirus. The assay may be automated to allow the screening of large numbers of compounds for anti-viral activity. Kits for carrying out the assay method are also disclosed.