Abstract: The invention relates to computer-implemented systems and methods for automatically discerning creation of handwritten verbiage (or typed) on a digital display; converting it to digital text objects that have been repaired (e.g., spelling, punctuation, etc.); and then inserting it as Scalable Vector Graphics onto the display.

Abstract: In some implementations, a plurality of thermoelectric devices may be arranged to cool one or more components of a downhole drilling component during drilling operations. A current can be applied to one or more thermoelectric devices to generate a cooling effect. The thermoelectric devices can be located and arranged so that they cool some or all of a bottom hole assembly or components thereof, such as one or more sensors, batteries, processors, electrics, and the like. The thermoelectric devices also may be located and arranged to cool sensors, batteries, other downhole components, and/or drilling mud in a wellbore during drilling operations. A plurality of thermoelectric devices may be used to generate electric power downhole from a temperature difference. The electric power may be used to power sensors, processors, charge batteries, and be used by one or more downhole electric components, such as those in a bottom hold assembly.

Abstract: In some implementations, a plurality of thermoelectric devices may be arranged to cool one or more components of a downhole drilling component during drilling operations. A current can be applied to one or more thermoelectric devices to generate a cooling effect. The thermoelectric devices can be located and arranged so that they cool some or all of a bottom hole assembly or components thereof, such as one or more sensors, batteries, processors, electrics, and the like. The thermoelectric devices also may be located and arranged to cool sensors, batteries, other downhole components, and/or drilling mud in a wellbore during drilling operations. A plurality of thermoelectric devices may be used to generate electric power downhole from a temperature difference. The electric power may be used to power sensors, processors, charge batteries, and be used by one or more downhole electric components, such as those in a bottom hold assembly.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for dynamic wave pairing. A graphics processor may allocate one or more GPU workloads to one or more wave slots of a plurality of wave slots. The graphics processor may select a first execution slot of a plurality of execution slots for executing the one or more GPU workloads. The selection may be based on one of a plurality of granularities. The graphics processor may execute, at the selected first execution slot, the one or more GPU workloads at the one of the plurality of granularities.

Abstract: Embodiments include in response to monitoring a processor during operation, detecting a first number of core recovery events in the processor, determining that the first number of core recovery events fulfills a first condition for the first core recovery events threshold, and modifying a value of at least one droop sensor parameter of the processor by a first amount. The at least one droop sensor parameters affects a sensitivity to a voltage droop. In response to modifying the value of the droop sensor parameter by the first amount, a second number of core recovery events is detected in the processor. It is determined that the second number of core recovery events fulfills a second condition for a second core recovery events threshold, and the value of the at least one droop sensor parameter is modified by a second amount.

Abstract: The present disclosure relates to dibenzoxanthene compounds that are efficient quenchers of fluorescence, for example in the far red and near infrared spectrum. Applications using the dibenzoxanthene quenching compounds and methods of making same are also described.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A vehicle includes an internal cabin, a plurality of stowage bin assemblies within the internal cabin, a plurality of passenger service units (PSUs) within the internal cabin, and an emergency oxygen system within the internal cabin. The plurality of stowage bin assemblies are uncoupled (for example, separate and distinct) from one or both of the plurality of PSUs or the emergency oxygen system. In an example, the plurality of stowage bin assemblies are uncoupled from the emergency oxygen system. In another example, the plurality of stowage bin assemblies are uncoupled from the plurality of PSUs. In another example, the plurality of stowage bin assemblies are uncoupled from both the plurality of PSUs and the emergency oxygen system.

Abstract: Aspects of this disclosure relate to a process for rendering graphics that includes performing, with a hardware unit of a graphics processing unit (GPU) designated for vertex shading, a vertex shading operation to shade input vertices so as to output vertex shaded vertices, wherein the hardware unit adheres to an interface that receives a single vertex as an input and generates a single vertex as an output. The process also includes performing, with the hardware unit of the GPU designated for vertex shading, a hull shading operation to generate one or more control points based on one or more of the vertex shaded vertices, wherein the one or more hull shading operations operate on at least one of the one or more vertex shaded vertices to output the one or more control points.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for improving visibility generation in tile-based GPU architectures. A graphics processor may perform a first binning pass associated with visibility information for each of a plurality of primitives in at least one frame. The visibility information for each of the plurality of primitives may correspond to a visible indication or an invisible indication. The graphics processor may update a depth buffer based on the visibility information for all of the plurality of primitives in the at least one frame. The graphics processor may perform a second binning pass for each of the visible set of primitives based on the updated depth buffer. The graphics processor may store at least one of the updated visibility information or updated position data for all primitives in the visible set of primitives from the second binning pass.

Abstract: Systems and techniques are provided for accelerated ray tracing. For instance, a process can include obtaining a hierarchical acceleration data structure that includes a plurality of primitives of a scene object and obtaining a respective information value associated with each primitive included in the plurality of primitives. A sort order can be determined for two or more nodes included in a same level of the hierarchical acceleration data structure at least in part by sorting the two or more nodes based on a respective sorting parameter value determined for each respective node of the two or more nodes. Each respective sorting parameter value can be determined based on at least one information value associated with one or more primitives included in a sub-tree of each respective node of the two or more nodes. The hierarchical acceleration data structure can be traversed using the sort order.

Abstract: The present disclosure relates to methods for detecting unique genetic signatures derived from markers such as, for example, mutations, somatic or germ-line, in nucleic acids obtained from biological samples. The sensitivity of the methods provides for detection of mutations associated with a disease, e.g., cancer mutations, or with inherited disease, e.g., an autosomal recessive disease, in a noninvasive manner at ultra-low proportions of sequences carrying mutations to sequences carrying normal, e.g., non-cancer sequences, or a reference sequence, e.g., a human reference genome.

Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for GPU wave-to-wave optimization. A graphics processor may execute a shader program for a first wave associated with a draw call or a compute kernel. The graphics processor may identify at least one first indication for the first wave associated with the draw call or the compute kernel. The graphics processor may store the at least one first indication for the first wave to a memory location. The graphics processor may execute the shader program for at least one second wave associated with the draw call or the compute kernel. The execution of the shader program for the at least one second wave may be based on the shader program for the at least one second wave reading the memory location to retrieve the at least one first indication.

Abstract: The present disclosure relates to a laboratory execution system that provides for automation of laboratory processes. A centralized data management system may be dynamically updated and used to facilitate management of components of the laboratory execution system, such as an automation system and an analytics results management system that may facilitate complex analytical functions, such as synthesizing raw test data. Potential workflows include the detection of specific molecules of interest.

Abstract: A sliced graphics processing unit (GPU) architecture in processor-based devices is disclosed. In some aspects, a GPU based on a sliced GPU architecture includes multiple hardware slices. The GPU further includes a command processor (CP) circuit and an unslice primitive controller (PC_US). Upon receiving a graphics instruction from a central processing unit (CPU), the CP circuit determines a graphics workload, and transmits the graphics workload to the PC_US. The PC_US then partitions the graphics workload into multiple subbatches and distributes each subbatch to a PC_S of a hardware slice for processing.

Abstract: A sliced graphics processing unit (GPU) architecture in processor-based devices is disclosed. In some aspects, a GPU based on a sliced GPU architecture includes multiple hardware slices. The GPU further includes a command processor (CP) circuit and an unslice primitive controller (PC_US). Upon receiving a graphics instruction from a central processing unit (CPU), the CP circuit determines a graphics workload, and transmits the graphics workload to the PC_US. The PC_US then partitions the graphics workload into multiple subbatches and distributes each subbatch to a PC_S of a hardware slice for processing.

Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for selecting actions from large discrete action sets. One of the methods includes receiving a particular observation representing a particular state of an environment; and selecting an action from a discrete set of actions to be performed by an agent interacting with the environment, comprising: processing the particular observation using an actor policy network to generate an ideal point; determining, from the points that represent actions in the set, the k nearest points to the ideal point; for each nearest point of the k nearest points: processing the nearest point and the particular observation using a Q network to generate a respective Q value for the action represented by the nearest point; and selecting the action to be performed by the agent from the k actions represented by the k nearest points based on the Q values.