Abstract: Methods, apparatus, and systems are provided for efficiently and accurately identifying individuals at risk for adverse effects from psychotropic or CNS-active treatment. Changes in a brain activity indicator (e.g. EEG cordance) are used to predict the adverse effects of treatment based on an experimentally derived cutoff value. For example, a reliable biological indicator is provided with high predictive capability for identifying, very early in the course of treatment (e.g. <=48 hours after start of treatment), those individuals who are at greatest risk for worsening suicidality and other adverse effects of antidepressant drugs.

Abstract: Methods, apparatus, and systems are provided for efficiently and accurately identifying individuals at risk for adverse effects from psychotropic or CNS-active treatment. Changes in a brain activity indicator (e.g. EEG cordance) are used to predict the adverse effects of treatment based on an experimentally derived cutoff value. For example, a reliable biological indicator is provided with high predictive capability for identifying, very early in the course of treatment (e.g. <=48 hours after start of treatment), those individuals who are at greatest risk for worsening suicidality and other adverse effects of antidepressant drugs.

Abstract: Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases. Mapping is used to determine activation during tasks such as motor and memory tasks, cognitive processing or other conditions, and also to assess the level of perfusion of the brain.

Abstract: Determining brain lesions by quantified electroencephalography is effected by obtaining absolute power data in a primary frequency domain for a brain region. Power data in the primary frequency domain in relation to power in a secondary frequency domain is determined. The two sets of data are related to obtain a value representative of the electrical output in the brain region. The representative value is compared to a selected base value and quantified departures are mapped topographically. This map is used to identify and assess lesions associated with disorders and afflictions including dementia and demyelinating diseases.

Abstract: Determining the brain condition of a human between normal and abnormal as determined by dementia, and selectively between dementia of the Alzheimer's-type and multi-infarct dementia is effected. Measures of electrical output, spectral ratio and coherence value of the brain are determined. Selected scores are applied to the electrical output, spectral ratio and coherence values. A relationship between the scores and addi-tionally the scored value of a coherence ratio are effected to obtain a diagnostic evaluation.