Abstract: The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.

Abstract: A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule.

Abstract: User input is received specifying components of a graph-based program specification. User input is received specifying links, at least some connecting an output port of an upstream component to an input port of a downstream component. The graph-based program specification is processed to identify one or more subsets of the components, including: identifying one or more subset entry points and one or more subset exit points that occur between components in different subsets based at least in part on data processing characteristics of linked components, and forming the subsets based on the identified subset entry points and exit points. A visual representation of the formed subsets is rendered within a user interface. Prepared code is generated for each formed subset that when used for execution by a runtime system causes processing tasks corresponding to the components in each formed subset to be performed.

Abstract: A graph-based program specification includes components corresponding to tasks and directed links between ports of the components, including: a first type of link configuration defined by respective output and input ports of linked components, and a second type of link configuration defined by respective output and input ports of linked components. A compiler recognizes different types of link configurations and provides in a target program specification occurrences of a target primitive for executing a function for each occurrence of a data element flowing over a link of the second type. A computing node initiates execution of the target program specification, and determines at runtime, for components associated with the occurrences of the target primitive, an order in which instances of tasks corresponding to the components are to be invoked, and/or a computing node on which instances of tasks corresponding to the components are to be executed.

Abstract: Information representative of a graph-based program specification has a plurality of components, each of which corresponds to a task, and directed links between ports of said components. A program corresponding to said graph-based program specification is executed. A first component includes a first data port, a first control port, and a second control port. Said first data port is configured to receive data to be processed by a first task corresponding to said first component, or configured to provide data that was processed by said first task corresponding to said first component. Executing a program corresponding to said graph-based program specification includes: receiving said first control information at said first control port, in response to receiving said first control information, determining whether or not to invoke said first task, and after receiving said first control information, providing said second control information from said second control port.

Abstract: User input is received specifying components of a graph-based program specification. User input is received specifying links, at least some connecting an output port of an upstream component to an input port of a downstream component. The graph-based program specification is processed to identify one or more subsets of the components, including: identifying one or more subset entry points and one or more subset exit points that occur between components in different subsets based at least in part on data processing characteristics of linked components, and forming the subsets based on the identified subset entry points and exit points. A visual representation of the formed subsets is rendered within a user interface. Prepared code is generated for each formed subset that when used for execution by a runtime system causes processing tasks corresponding to the components in each formed subset to be performed.

Abstract: A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule.

Abstract: A first component of a graph-based program specification includes an output control port. A second component includes an input control port and an input data port. A third component includes an output data port. The output control port is connected to the input control port, and the output data port is connected to the input data port. The first component includes control code that when executed causes the output control port to provide, to the input control port, at least one of suppression information or invocation information. The second component includes control code that when executed causes a computing system configured by the graph-based program specification to begin processing data received at the input data port in response to the invocation information if no suppression information is received at the input control port before the invocation information is received at the input control port.

Abstract: A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule.

Abstract: A graph-based program specification includes components corresponding to tasks and directed links between ports of the components, including: a first type of link configuration defined by respective output and input ports of linked components, and a second type of link configuration defined by respective output and input ports of linked components. A compiler recognizes different types of link configurations and provides in a target program specification occurrences of a target primitive for executing a function for each occurrence of a data element flowing over a link of the second type. A computing node initiates execution of the target program specification, and determines at runtime, for components associated with the occurrences of the target primitive, an order in which instances of tasks corresponding to the components are to be invoked, and/or a computing node on which instances of tasks corresponding to the components are to be executed.

Abstract: Information representative of a graph-based program specification has a plurality of components, each of which corresponds to a task, and directed links between ports of said components. A program corresponding to said graph-based program specification is executed. A first component includes a first data port, a first control port, and a second control port. Said first data port is configured to receive data to be processed by a first task corresponding to said first component, or configured to provide data that was processed by said first task corresponding to said first component. Executing a program corresponding to said graph-based program specification includes: receiving said first control information at said first control port, in response to receiving said first control information, determining whether or not to invoke said first task, and after receiving said first control information, providing said second control information from said second control port.

Abstract: User input is received specifying components of a graph-based program specification. User input is received specifying links, at least some connecting an output port of an upstream component to an input port of a downstream component. The graph-based program specification is processed to identify one or more subsets of the components, including: identifying one or more subset entry points and one or more subset exit points that occur between components in different subsets based at least in part on data processing characteristics of linked components, and forming the subsets based on the identified subset entry points and exit points. A visual representation of the formed subsets is rendered within a user interface. Prepared code is generated for each formed subset that when used for execution by a runtime system causes processing tasks corresponding to the components in each formed subset to be performed.

Abstract: A graph-based program specification includes components corresponding to tasks and directed links between ports of the components, including: a first type of link configuration between ports of linked components, corresponding to transfer of control or transfer of a single data element, and a second type of link configuration between ports of linked components, corresponding to transfer of multiple data elements. A compiler generates a target program specification including control code representing at least one control graph including graph nodes representing the components, where at least two are connected based on links of the first type. A computing node initiates execution of the target program specification, and manages computing resources for links of the second type, the computing resources including at least one of: (1) a buffer for storing data elements provided by an output port, or (2) a buffer for storing data elements provided to an input port.

Abstract: Information representative of a graph-based program specification has a plurality of components, each of which corresponds to a task, and directed links between ports of said components. A program corresponding to said graph-based program specification is executed. A first component includes a first data port, a first control port, and a second control port. Said first data port is configured to receive data to be processed by a first task corresponding to said first component, or configured to provide data that was processed by said first task corresponding to said first component. Executing a program corresponding to said graph-based program specification includes: receiving said first control information at said first control port, in response to receiving said first control information, determining whether or not to invoke said first task, and after receiving said first control information, providing said second control information from said second control port.

Abstract: A first component of a graph-based program specification includes an output control port. A second component includes an input control port and an input data port. A third component includes an output data port. The output control port is connected to the input control port, and the output data port is connected to the input data port. The first component includes control code that when executed causes the output control port to provide, to the input control port, at least one of suppression information or invocation information. The second component includes control code that when executed causes a computing system configured by the graph-based program specification to begin processing data received at the input data port in response to the invocation information if no suppression information is received at the input control port before the invocation information is received at the input control port.

Abstract: A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule.

Abstract: A first component of a graph-based program specification includes an output control port. A second component includes an input control port and an input data port. A third component includes an output data port. The output control port is connected to the input control port, and the output data port is connected to the input data port. The first component includes control code that when executed causes the output control port to provide, to the input control port, at least one of suppression information or invocation information. The second component includes control code that when executed causes a computing system configured by the graph-based program specification to begin processing data received at the input data port in response to the invocation information if no suppression information is received at the input control port before the invocation information is received at the input control port.

Abstract: A computer-implemented method includes accessing a plurality of data records, each data record having a plurality of data fields. The method further includes analyzing values for one or more of the data fields for at least some of the plurality of data records and generating a profile of the plurality of data records based on the analyzing. The method further includes formulating at least one subsetting rule based on the profile; and selecting a subset of data records from the plurality of data records based on the at least one subsetting rule.

Abstract: Information representative of a graph-based program specification has a plurality of components, each of which corresponds to a task, and directed links between ports of said components. A program corresponding to said graph-based program specification is executed. A first component includes a first data port, a first control port, and a second control port. Said first data port is configured to receive data to be processed by a first task corresponding to said first component, or configured to provide data that was processed by said first task corresponding to said first component. Executing a program corresponding to said graph-based program specification includes: receiving said first control information at said first control port, in response to receiving said first control information, determining whether or not to invoke said first task, and after receiving said first control information, providing said second control information from said second control port.

Abstract: A graph-based program specification includes components corresponding to tasks and directed links between ports of the components, including: a first type of link configuration defined by respective output and input ports of linked components, and a second type of link configuration defined by respective output and input ports of linked components. A compiler recognizes different types of link configurations and provides in a target program specification occurrences of a target primitive for executing a function for each occurrence of a data element flowing over a link of the second type. A computing node initiates execution of the target program specification, and determines at runtime, for components associated with the occurrences of the target primitive, an order in which instances of tasks corresponding to the components are to be invoked, and/or a computing node on which instances of tasks corresponding to the components are to be executed.