Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for selectively reducing pathogenic isoforms (e.g., DNAJB6) in a subject having a neuromuscular disorder. An aspect of the present disclosure provides for selectively reducing DNAJB6 in a subject having a neuromuscular disorder (e.g., limb-girdle muscular dystrophy D1 (LGMD-D1)) comprising administering an amount of a DNAJB6-targeting antisense oligonucleotide (ASO) sufficient to reduce the expression of DNAJB6 compared to the subject prior to being administered the DNAJB6-targeting ASO.

Abstract: The present application relates to aqueous slurries comprising precipitated calcium carbonates having a bimodal particle size distribution with a first maximum in particle size distribution and a second maximum in particle size distribution, as well as methods for making them and their uses.

Abstract: Use of a particulate mineral having a coating of one or more rosin acid(s) and/or one or more derivative(s) thereof as a pitch and/or stickies control agent in a composition comprising cellulosic pulp, a method of reducing dissolved and/or colloidal pitch and/or stickies in cellulosic pulp using said coated particulate minerals, said coated particulate mineral, a method of making said coated particulate mineral, a composition comprising cellulosic pulp and said coated particulate mineral and paper comprising said coated particulate mineral.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for selectively reducing pathogenic isoforms (e.g., DNAJB6) in a subject having a neuromuscular disorder. An aspect of the present disclosure provides for selectively reducing DNAJB6 in a subject having a neuromuscular disorder (e.g., limb-girdle muscular dystrophy D1 (LGMD-D1)) comprising administering an amount of a DNAJB6-targeting antisense oligonucleotide (ASO) sufficient to reduce the expression of DNAJB6 compared to the subject prior to being administered the DNAJB6-targeting ASO.

Abstract: Inorganic particulate compositions containing inorganic particles associated with a copolymer of a hydrophilic monomer and a hydrophobic monomer associated with the inorganic particles are provided. The particulate composition satisfies at least one of the following properties: a BET surface area of the inorganic particles is greater than 8 m2/g, a Hegman value of the inorganic particles is 75 microns or less, and a rate of water loss from the composition upon drying from a moisture level greater than 2% wt % is at least 30% greater than a composition having a corresponding content of a polyacrylate polymer associated with the particles. A method to prepare the composition and formulations for inks, paints, coatings and filled polymeric articles containing the inorganic particulate composition are also provided.

Abstract: Inorganic particulate compositions containing inorganic particles associated with a copolymer of a hydrophilic monomer and a hydrophobic monomer associated with the inorganic particles are provided. The particulate composition satisfies at least one of the following properties: a BET surface area of the inorganic particles is greater than 8 m2/g, a Hegman value of the inorganic particles is 75 microns or less, and a rate of water loss from the composition upon drying from a moisture level greater than 2% wt % is at least 30% greater than a composition having a corresponding content of a polyacrylate polymer associated with the particles. A method to prepare the composition and formulations for inks, paints, coatings and filled polymeric articles containing the inorganic particulate composition are also provided.

Abstract: The present application relates to aqueous slurries comprising precipitated calcium carbonates having a bimodal particle size distribution with a first maximum in particle size distribution and a second maximum in particle size distribution, as well as methods for making them and their uses.

Abstract: Inorganic particulate compositions containing inorganic particles associated with a copolymer of a hydrophilic monomer and a hydrophobic monomer associated with the inorganic particles are provided. The particulate composition satisfies at least one of the following properties: a BET surface area of the inorganic particles is greater than 8 m2/g, a Hegman value of the inorganic particles is 75 microns or less, and a rate of water loss from the composition upon drying from a moisture level greater than 2% wt % is at least 30% greater than a composition having a corresponding content of a polyacrylate polymer associated with the particles. A method to prepare the composition and formulations for inks, paints, coatings and filled polymeric articles containing the inorganic particulate composition are also provided.

Abstract: Inorganic particulate compositions containing inorganic particles associated with a copolymer of a hydrophilic monomer and a hydrophobic monomer associated with the inorganic particles are provided. The particulate composition satisfies at least one of the following properties: a BET surface area of the inorganic particles is greater than 8 m2/g, a Hegman value of the inorganic particles is 75 microns or less, and a rate of water loss from the composition upon drying from a moisture level greater than 2% wt % is at least 30% greater than a composition having a corresponding content of a polyacrylate polymer associated with the particles. A method to prepare the composition and formulations for inks, paints, coatings and filled polymeric articles containing the inorganic particulate composition are also provided.

Abstract: A method for measuring charging of a semiconductor wafer associated with processing the semiconductor wafer includes using a probe assembly at a charge monitoring module to measure a charge on the semiconductor wafer prior to processing the semiconductor wafer using a processing tool, the probe assembly being located proximate to a processing station of the processing tool; transferring the semiconductor wafer from the charge monitoring module to the processing station using an automated wafer handling apparatus; processing the semiconductor wafer at the processing station using the processing tool; transferring the processed wafer from the processing station back to the charge monitoring module; using the probe assembly at the charge monitoring module to measure a charge on the semiconductor wafer after processing the wafer; and analyzing the measured charge on the semiconductor wafer both before and after processing the semiconductor wafer to determine information about charging of the wafer due to processi

Abstract: Methods and apparatuses for addressing open space noise are disclosed using both dynamic and static sound masking. In one example, an adaptive sound masking system and method portions undesired sound into time-blocks and estimates frequency spectrum and power level, and continuously generates masking noise with a matching or predetermined spectrum and loudness or power level to mask the undesired sound. In another example, a static sound masking system and method portions undesired sound into time-blocks and estimates frequency spectrum and power level, and generates a static noise-masking signal with a matching spectrum and power level to mask the undesired sound.

Abstract: A crankshaft has a receiving platform for catching lubricant dropping from a main bearing assembly. The receiving platform has at least one wall disposed thereon. The wall has one point that is the furthest from the rotational axis of the crankshaft. One channel is defined in the platform and has an inlet disposed close to the point of the wall that is furthest from the rotational axis of the crankshaft. The channel has an outlet in the vicinity of a connecting rod bearing assembly, so that lubricant dropped on the receiving platform will flow to the connecting rod bearing assembly.

Abstract: A common communications protocol is described among devices in a unified communications network. Native devices receive upstream commands and forward them to downstream devices without interpreting the commands. The native devices reformat commands intended for mapped devices in the unified communications network. The common communications protocol calls for left shifting address fields for transmitted commands until the command arrives at its intended destination.

Abstract: A crankshaft has a receiving platform for catching lubricant dropping from a main bearing assembly. The receiving platform has at least one wall disposed thereon. The wall has one point that is the furthest from the rotational axis of the crankshaft. One channel is defined in the platform and has an inlet disposed close to the point of the wall that is furthest from the rotational axis of the crankshaft. The channel has an outlet in the vicinity of a connecting rod bearing assembly, so that lubricant dropped on the receiving platform will flow to the connecting rod bearing assembly.

Abstract: Systems and methods for establishing conference calls using a headset are presented. The headset includes a wireless communications transceiver operable to form a first local wireless link with a first local telephone in communication with a first far end telephone user and a second local wireless link with a second local telephone in communication with a second far end telephone user. The headset further includes a processor operable to establish a conference call between the headset user, the first far end telephone user, and the second far end telephone user.

Abstract: Systems and methods for establishing conference calls using a headset are presented. The headset includes a wireless communications transceiver operable to form a first local wireless link with a first local telephone in communication with a first far end telephone user and a second local wireless link with a second local telephone in communication with a second far end telephone user. The headset further includes a processor operable to establish a conference call between the headset user, the first far end telephone user, and the second far end telephone user.