Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.

Abstract: Systems and methods for dynamically adjusting a MAP advance time for a MAP message sent from a CCAP core to an RPD, based on a comparison of at least one measured latency value against at least one threshold.

Abstract: Systems and methods for dynamically adjusting a MAP advance time for a MAP message sent from a CCAP core to an RPD, the MAP message allocating bandwidth for the RPD during an interval beginning at a start time specified in the MAP message.

Abstract: An inductive cooktop includes a transparent panel that supports a cookware object. An electrically actuated panel, such as a display panel, is disposed below the transparent panel. The electrically actuated panel includes two sets of lines, such as data and scan lines, disposed orthogonal to each other to form a two-dimensional matrix that is configured to operate associated elements with an addressing scheme. An array of induction coils are disposed below the electrically actuated panel that are each operable to generate an electromagnetic field that inductively couples with the cookware object supported at the transparent panel. The induction coils are operable to generate an electromagnetic field with a flux direction in general parallel alignment with one set of lines, such as the data lines, to prevent the electromagnetic field from inducing a voltage on the lines.

Abstract: An inductive cooktop system includes a top plate that has a top surface for supporting a cookware object. A display is disposed below the top plate, and induction coils are arranged in a matrix and disposed vertically below the display. The induction coils are each operable to generate a magnetic field that partially extends above the top surface of the top plate to couple with the cookware object. A control system receives an initial input indicating a position of the cookware object on the top surface of the top plate. Data processing hardware of the control system then determines the pixels of the display corresponding to the indicated position from the input. The control system then generates a graphic at the indicated position for the cookware object by illuminating the plurality of pixels of the display.

Abstract: A system for improving a display coupled to an inductive cooktop includes an induction coil and an electrically-actuated display (EAD) assembly. The induction coil includes a magnetic field. The EAD assembly is disposed on the induction coil and includes a frontplate adjacent to the induction coil and a thin film transistor (TFT) array backplane opposite the frontplane. The TFT array backplane includes a scan line with some degree of orthogonality to the magnetic field and a data line with some degree of parallelism to the magnetic field. The scan line and the data line are configured to activate a display pixel corresponding to the EAD assembly. One or more ground lines of the EAD assembly have some degree of parallelism to the magnetic field of the induction coil.

Abstract: An inductive cooktop includes a top plate that has an upper surface that supports a cookware object. An induction coil is disposed below the top plate and is operable to generate an electromagnetic field that is configured to heat the cookware object. A display, such as an OLED display, is disposed between the inductive coil and the top plate and operates to emit light through the top plate, such as to display information that is visible at the upper surface of top plate. A transparent thermal insulator is provided to prevent the cookware object from heating the display above a threshold temperature. The transparent thermal insulator may include a silica aerogel material, which may be disposed between an upper glass panel and a lower glass panel.

Abstract: A system and method for removing vegetable gums from a vegetable oil tank for subsequent reuse is provided, as well as methods of using the same. The system and method of removing vegetable gums from a vegetable oil storage tank may provide the storage tank including the vegetable gums; provide a holding tank comprising a heating element; suck the vegetable gums up from the storage tank into a first conduit; transport the vegetable gums to the holding tank via the first conduit; and heat the vegetable gums in the holding tank, wherein the holding tank is configured to facilitate movement of the holding tank.

Abstract: Tetrahydronaphthyridines of formula are disclosed. These compounds selectively inhibit ?V?3 without activating the ?V?3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing ?V?3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.

Abstract: The development of a new, targeted drug delivery paradigm coupled to improved PI3K inhibitors (e.g., PI3K? inhibitors) represents a significant advance in cancer therapy. Provided herein are compounds, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds provided herein are PI3K (e.g., PI3K?) inhibitors and are therefore useful for the treatment and/or prevention of various diseases (e.g., proliferative diseases such as cancer). Also provided herein are nanoparticles and nanogels (e.g., P-selectin targeting nanoparticles) comprising PI3K inhibitors, such a compound described herein. In certain embodiments, a nanoparticle or nanogel described herein encapsulates a compound described herein for targeting delivery to cancer cells or tumors.

Abstract: Medical instruments with shaft actuating handles configured to accept stylets are disclosed. In one aspect, a medical instrument includes an elongate channel having a distal end, a tool configured to be extended from and retracted into the distal end of the elongate channel, and a handle configured to drive movement of the tool between a retracted position and an extended position. The handle includes a casing, a handle member coupled to the tool and configured to move with respect to the casing as the tool is moved between the retracted position and the extended position, a fluid fitting coupled to the casing, and a flexible tube connecting the fluid fitting to the handle member and forming a portion of a lumen. The flexible tube is configured to allow a stylet to pass through the lumen when the tool is in the extended position.

Abstract: Systems and methods for dynamically adjusting a MAP advance time for a MAP message sent from a CCAP core to an RPD, the MAP message allocating bandwidth for the RPD during an interval beginning at a start time specified in the MAP message.

Abstract: Systems and methods relating to medical technology are disclosed. For example, a medical robotic system can include first and second robotic arms. An introducer can be coupled to the first robotic arm. The introducer can include a first opening, a second opening, and a channel connecting the first opening and the second opening. A flexible elongate medical tool can be coupled to the second robotic arm. The second robotic arm can be configured to drive the flexible elongate medical tool through the introducer coupled to the first robotic arm and into a patient.

Abstract: A system and method for removing vegetable gums from a vegetable oil tank for subsequent reuse is provided, as well as methods of using the same. The system and method of removing vegetable gums from a vegetable oil storage tank may provide the storage tank including the vegetable gums; provide a holding tank comprising a heating element; suck the vegetable gums up from the storage tank into a first conduit; transport the vegetable gums to the holding tank via the first conduit; and heat the vegetable gums in the holding tank, wherein the holding tank is configured to facilitate movement of the holding tank.

Abstract: A system provides an elongated display that has a touchscreen with a multi-user interactive display area that is accessible simultaneously by at least two users. A sensor may monitor users at or near the interactive display area of the touchscreen, such as to transmit a sensor signal that identifies the presence of a user, which may be used to determine a location of the user relative to the elongated display. A characteristic of the user may also be identified with a sensor, where the characteristic may correspond with a user profile. The elongated display may display an image at a section of the interactive display area near the location of the user, where the image corresponds with a preselected setting of the user profile.

Abstract: A system provides an elongated display that has a touchscreen with a multi-user interactive display area that is accessible simultaneously by at least two users. A sensor may monitor users at or near the interactive display area of the touchscreen, such as to transmit a sensor signal that identifies the presence of a user, which may be used to determine a location of the user relative to the elongated display. A characteristic of the user may also be identified with a sensor, where the characteristic may correspond with a user profile. The elongated display may display an image at a section of the interactive display area near the location of the user, where the image corresponds with a preselected setting of the user profile.

Abstract: Tetrahydronaphthyridines of formula are disclosed. These compounds selectively inhibit ?V?3 without activating the ?V?3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing ?V?3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.

Abstract: A garment having a piece of clothing with a plurality of pad segments located proximate a backside of a wearer's body, including at least one joint region, for protecting the wearer by dissipating energy resulting from a sudden impact. The pad segments arranged with respect to the interior radius of the joint region such that an interstitial space located between each adjacent pad segment becomes narrower moving a protruding portion of each adjacent pad segment closer together, and in some instances such that the adjacent protruding portions touch one another, when the joint region moves from an extended position to a flexed position. The garment with energy dissipating pad segments may be used alone or in conjunction with pads that shield energy.

Abstract: A garment having a piece of clothing with a plurality of pad segments located proximate a backside of a wearer's body, including at least one joint region, for protecting the wearer by dissipating energy resulting from a sudden impact. The pad segments arranged with respect to the interior radius of the joint region such that an interstitial space located between each adjacent pad segment becomes narrower moving a protruding portion of each adjacent pad segment closer together, and in some instances such that the adjacent protruding portions touch one another, when the joint region moves from an extended position to a flexed position. The garment with energy dissipating pad segments may be used alone or in conjunction with pads that shield energy.