Abstract: Systems and methods are disclosed for categorizing and/or characterizing a user interface. The systems and methods include generating acoustic data associated with an acoustic reflection of an acoustic signal, the acoustic reflection being indicative of, at least in part, one or more features of a user interface coupled to a respiratory therapy device via a conduit. The systems and methods further include analyzing the generated acoustic data. The systems and methods further include categorizing and/or characterizing the user interface based, at least in part, on the analyzed acoustic data.

Abstract: This disclosure relates generally to biomarkers of inflammatory disease. More particularly, the present disclosure relates to biomarkers and their use in methods, compositions, apparatuses, devices and kits for determining an indicator that is useful for assessing a likelihood that a type of inflammation is present or absent in a joint of a subject.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: A method of determining a sleep stage of an individual comprises identifying features associated with a current epoch of the sleep session, determining a plurality of sleep stage probabilities based on the features, identifying events experienced by the individual during the current epoch, and adjusting each of the plurality of sleep stage probabilities based on events experienced by the individual during the current epoch or a prior epoch, and/or a sleep stage previously determined for the prior epoch. The features include at least one feature associated with a flow of pressurized air from a respiratory therapy system used by the individual, at least one feature associated with a respiration rate of the individual, and/or at least one feature associated with a time of the sleep session. Each sleep stage probability corresponds to a respective one of a plurality of potential sleep stages during the current epoch of the sleep session.

Abstract: Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections.

Abstract: According to some implementations of the present disclosure, a method includes receiving acoustic data associated with airflow caused by operation of a respiratory therapy system, which is configured to supply pressurized air to a user. The respiratory therapy system includes a user interface and a vent. The method also includes determining, based at least in part on a portion of the received acoustic data, an acoustic signature associated with the vent. The method also includes characterizing, based at least in part on the acoustic signature associated with the vent, the user interface, the vent, or both.

Abstract: The present disclosure relates to a method for identifying a user interface. Flow data associated with air flowing in a respiratory therapy system is received. Acoustic data associated with the respiratory therapy system is received. The received flow data and the received acoustic data are analyzed. Based at least in part on the analysis, a mask type for the user interface is determined.

Abstract: A multi-grain selector device includes an outer body having exterior surfaces. The outer body includes a cooling side configured to face a cooling plate of a casting furnace and an opposite mold side configured to face into a mold. The outer body includes an array of multiple grain selector columns each formed from two or more transversely oriented, elongated channels that are fluidly coupled with each other in an end-to-end arrangement oriented along a growth direction that extends from the cooling side of the outer body toward the mold side of the outer body. The selector columns extend to growth openings on the mold side of the outer body. Each of the selector columns is configured to form a single grain column out of the corresponding growth opening that is part of a columnar grained article to be formed in the mold that grows along the growth direction.

Abstract: Systems and methods are disclosed for categorizing and/or characterizing a user interface. The systems and methods include generating acoustic data associated with an acoustic reflection of an acoustic signal, the acoustic reflection being indicative of, at least in part, one or more features of a user interface coupled to a respiratory therapy device via a conduit. The systems and methods further include analyzing the generated acoustic data. The systems and methods further include categorizing and/or characterizing the user interface based, at least in part, on the analyzed acoustic data.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.

Abstract: A method includes generating acoustic data representative of at least one or more reflections of an acoustic signal. The one or more reflections are indicative of a length and/or a diameter of a conduit coupled to a respiratory therapy device. The method further includes analyzing the acoustic data to determine the length and/or diameter of the conduit. In some cases, analyzing the acoustic data includes determining a resonant frequency of the conduit, and determining the length of the conduit based at least in part on the resonant frequency. In some cases, analyzing the acoustic data includes comparing the acoustic data to predetermined sets of acoustic data that each correspond to a known length and/or diameter of the conduit, and selecting one of the predetermined sets of acoustic data that best matches the generated acoustic data. The selected set of acoustic data corresponds to the length and/or diameter of the conduit.

Abstract: A method includes receiving first physiological data associated with a user. The method also includes determining a first emotion score associated with the user based at least in part on the first physiological data. The method also includes modifying one or more settings of a respiratory therapy system responsive to determining that the first emotion score satisfies a predetermined condition.

Abstract: A driver login device includes: a network communication unit in communication with the server via a network; an image pickup device capturing a target to obtain a login data; an image processing unit electrically coupled to the image pickup unit, and receiving and processing the login data to obtain a digital data; and a central processing unit electrically coupled to the network communication unit, the image pickup device and the image processing unit. The central processing unit, by way of the network communication unit, receives the data of the driver from the server via the network, controls the image pickup device to capture the target, comparing the digital data with the data of the driver to generate a comparing result, and by way of the network communication unit, transmitting the comparing result back to the server via the network.

Abstract: A system includes an electronic circuit, a memory, and a control system. The electronic circuit is coupled to a conduit. The conduit may be configured to deliver pressurized air. A portion of the electronic circuit has a first electrical property that is configured to change based at least in part on movement of the portion of the electronic circuit. The memory stores machine-readable instructions. The control system includes one or more processors configured to execute the machine-readable instructions. Data associated with the first electrical property of the electronic circuit is received. The received data is analyzed. Based at least in part on the analysis, it is determined that the first electrical property of the electronic circuit has changed. Responsive to the determination that the first electrical property of the electronic circuit has changed, it is determined that the conduit is moving or has moved.