Abstract: The invention relates to 4-((6-oxopyrimidin-1(6H)-yl)methyl)benzoic acid, compositions thereof, and uses of either, for example in the treatment of ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: Provided is a precision metering and delivery apparatus and method of use for the precise distribution of viable pollen in diluent or other particulate material via metering and delivery of said pollen or other particulate material, said precision metering apparatus comprising a metering apparatus, a delivery system, and a storage device. Apparatuses of the present invention ensure that the pollen or other particulate material is not harmed during the delivery and that the pollen is applied in the correct density or amount.

Abstract: A message including metadata is received on behalf of an application operator from a subscriber by a message management platform. Based on the metadata, the message is determined to be associated with a customer record received by the message management platform as an application programming interface (API) notification from an application builder platform. The API notification includes a payload that includes information describing a committed transaction event associated with a user of the application builder platform. An interaction history associated with the subscriber is presented in a messaging interface of the message management platform. The interaction history includes the message received from the subscriber and further including a user action item describing the committed transaction event associated with the user of the application builder platform.

Abstract: A system for designing a robot for performing a specified function includes a library, a robot design server, and a robot data server. The library stores data about modules and accessories for a robot and has at least unique IDs, dimensions, and firmware for operation of each module and accessory. The robot design server receives a set of functions and requirements of the new robot, finds a set of modules or accessories which match at least one of the set of functions and requirements, performs a set of validation tests against a set of criteria, identifies at least one design which passed the set of validation tests, and generates a list of modules and accessories and their unique IDs of a selected design and a connection map for the selected design. The robot data server downloads to the assembled robot the data and metadata of its modules and accessories.

Abstract: The invention provides a sensor for detecting a nucleic acid, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a sensing element, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element comprises: (i) a semiconducting portion of the substrate, wherein a conduction path between the terminal electrodes passes through the semiconducting portion; and (ii) an oligonucleotide on a surface of the semiconducting portion, the oligonucleotide being complementary to the nucleic acid to be detected, wherein hybridisation of the nucleic acid with the oligonucleotide leads to a change in resistance of the sensor.

Abstract: A message including metadata is received on behalf of an application operator from a subscriber by a message management platform. Based on the metadata, the message is determined to be associated with a customer record received by the message management platform as an application programming interface (API) notification from an application builder platform. The API notification includes a payload that includes information describing a committed transaction event associated with a user of the application builder platform. An interaction history associated with the subscriber is presented in a messaging interface of the message management platform. The interaction history includes the message received from the subscriber and further including a user action item describing the committed transaction event associated with the user of the application builder platform.

Abstract: Compositions and methods are provided for genome modification of a nucleotide sequence located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell or plant to produce a male-sterile plant. In some examples, the methods and compositions employ a guide RNA/Cas endonuclease system for modifying or altering target sites located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell, plant or seed to produce a male-sterile plant. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification a nucleotide sequence located in or near a male fertility gene of MS9, MS22, MS26, or MS45 in the genome of a plant cell to produce a male-sterile plant. Compositions and methods are also provided for restoring fertility to a Ms9, Ms22, Ms26, or Ms45 nucleotide sequence to a male-sterile Ms9, Ms22, Ms26, or Ms45 plant produced using the methods and compositions described herein.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: A method of determining a sleep stage of an individual comprises identifying features associated with a current epoch of the sleep session, determining a plurality of sleep stage probabilities based on the features, identifying events experienced by the individual during the current epoch, and adjusting each of the plurality of sleep stage probabilities based on events experienced by the individual during the current epoch or a prior epoch, and/or a sleep stage previously determined for the prior epoch. The features include at least one feature associated with a flow of pressurized air from a respiratory therapy system used by the individual, at least one feature associated with a respiration rate of the individual, and/or at least one feature associated with a time of the sleep session. Each sleep stage probability corresponds to a respective one of a plurality of potential sleep stages during the current epoch of the sleep session.

Abstract: Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections.

Abstract: According to some implementations of the present disclosure, a method includes receiving acoustic data associated with airflow caused by operation of a respiratory therapy system, which is configured to supply pressurized air to a user. The respiratory therapy system includes a user interface and a vent. The method also includes determining, based at least in part on a portion of the received acoustic data, an acoustic signature associated with the vent. The method also includes characterizing, based at least in part on the acoustic signature associated with the vent, the user interface, the vent, or both.

Abstract: The present disclosure relates to a method for identifying a user interface. Flow data associated with air flowing in a respiratory therapy system is received. Acoustic data associated with the respiratory therapy system is received. The received flow data and the received acoustic data are analyzed. Based at least in part on the analysis, a mask type for the user interface is determined.

Abstract: A multi-grain selector device includes an outer body having exterior surfaces. The outer body includes a cooling side configured to face a cooling plate of a casting furnace and an opposite mold side configured to face into a mold. The outer body includes an array of multiple grain selector columns each formed from two or more transversely oriented, elongated channels that are fluidly coupled with each other in an end-to-end arrangement oriented along a growth direction that extends from the cooling side of the outer body toward the mold side of the outer body. The selector columns extend to growth openings on the mold side of the outer body. Each of the selector columns is configured to form a single grain column out of the corresponding growth opening that is part of a columnar grained article to be formed in the mold that grows along the growth direction.

Abstract: Systems and methods are disclosed for categorizing and/or characterizing a user interface. The systems and methods include generating acoustic data associated with an acoustic reflection of an acoustic signal, the acoustic reflection being indicative of, at least in part, one or more features of a user interface coupled to a respiratory therapy device via a conduit. The systems and methods further include analyzing the generated acoustic data. The systems and methods further include categorizing and/or characterizing the user interface based, at least in part, on the analyzed acoustic data.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.