Abstract: A system, including an analysis server computer, a robot that is configured to participate in interactions with one or more participants; wherein the robot is configured to collect information related to the participants during the interaction, wherein the robot accepts a summary report related to the interaction from a participant or forms a summary report, wherein the robot is configured to forward the summary report to the analysis server for analysis, wherein the analysis server is configured to analyze the summary report and determine if the summary report should pass or fail, when the summary report passes the analysis server is configured to store the summary report in a database; and when the summary report fails the analysis server is configured to provide feedback to the robot with a list of problems for correction in the summary report.

Abstract: The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A physical connector includes an intelligent locking system (which may further include a mechanical locking system) that operates to connect modules of a modular system that further contains data and power connectors along at least one bus system wherein the internal connectors may be modularized (and broken down into subsets as the data and power connecting lines propagate through the system), wherein the connector includes a transponder capable of communicating with another transponder of a different connector, wherein the transponder holds basic data on the connecting module and connecting modules down the connection line and that basic data is interpreted by a core module with use of a data library.

Abstract: A pair of ground planes arranged in parallel, a dielectric medium disposed in between the pair of ground planes, and a set of at least four signal conductors disposed in the dielectric medium, the set of at least four signal conductors having (i) a first pair of signal conductors arranged proximate to a first ground plane of the pair of ground planes and (ii) a second pair of signal conductors arranged proximate to a second ground plane of the pair of ground planes, each signal conductor of the set of at least four signal conductors configured to carry a respective signal corresponding to a symbol of a codeword of a vector signaling code.

Abstract: Systems and methods are disclosed for categorizing and/or characterizing a user interface. The systems and methods include generating acoustic data associated with an acoustic reflection of an acoustic signal, the acoustic reflection being indicative of, at least in part, one or more features of a user interface coupled to a respiratory therapy device via a conduit. The systems and methods further include analyzing the generated acoustic data. The systems and methods further include categorizing and/or characterizing the user interface based, at least in part, on the analyzed acoustic data.

Abstract: This disclosure relates generally to biomarkers of inflammatory disease. More particularly, the present disclosure relates to biomarkers and their use in methods, compositions, apparatuses, devices and kits for determining an indicator that is useful for assessing a likelihood that a type of inflammation is present or absent in a joint of a subject.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: A method of determining a sleep stage of an individual comprises identifying features associated with a current epoch of the sleep session, determining a plurality of sleep stage probabilities based on the features, identifying events experienced by the individual during the current epoch, and adjusting each of the plurality of sleep stage probabilities based on events experienced by the individual during the current epoch or a prior epoch, and/or a sleep stage previously determined for the prior epoch. The features include at least one feature associated with a flow of pressurized air from a respiratory therapy system used by the individual, at least one feature associated with a respiration rate of the individual, and/or at least one feature associated with a time of the sleep session. Each sleep stage probability corresponds to a respective one of a plurality of potential sleep stages during the current epoch of the sleep session.

Abstract: Disclosed are methods, apparatus, kits and compositions for determining the absence of a systemic bacterial infection (sepsis) in patients, particularly ones presenting to hospital emergency departments (ED) as outpatients, by measurement of the host immune response using peripheral blood. The are methods, apparatus, kits and compositions can be used in mammals for diagnosing, making treatment decisions, determining the next procedure or diagnostic test, or management of patients suspected of having an infection, including those presenting with fever or other signs of systemic inflammation. More particularly, peripheral blood RNA and protein biomarkers are disclosed that are useful for distinguishing between the host immune response to bacteria compared to the host immune response to other causes of systemic inflammation including trauma, burns, autoimmune disease, asthma, anaphylaxis, arthritis, obesity and viral infections.

Abstract: According to some implementations of the present disclosure, a method includes receiving acoustic data associated with airflow caused by operation of a respiratory therapy system, which is configured to supply pressurized air to a user. The respiratory therapy system includes a user interface and a vent. The method also includes determining, based at least in part on a portion of the received acoustic data, an acoustic signature associated with the vent. The method also includes characterizing, based at least in part on the acoustic signature associated with the vent, the user interface, the vent, or both.

Abstract: The present disclosure relates to a method for identifying a user interface. Flow data associated with air flowing in a respiratory therapy system is received. Acoustic data associated with the respiratory therapy system is received. The received flow data and the received acoustic data are analyzed. Based at least in part on the analysis, a mask type for the user interface is determined.

Abstract: A multi-grain selector device includes an outer body having exterior surfaces. The outer body includes a cooling side configured to face a cooling plate of a casting furnace and an opposite mold side configured to face into a mold. The outer body includes an array of multiple grain selector columns each formed from two or more transversely oriented, elongated channels that are fluidly coupled with each other in an end-to-end arrangement oriented along a growth direction that extends from the cooling side of the outer body toward the mold side of the outer body. The selector columns extend to growth openings on the mold side of the outer body. Each of the selector columns is configured to form a single grain column out of the corresponding growth opening that is part of a columnar grained article to be formed in the mold that grows along the growth direction.

Abstract: Systems and methods are disclosed for categorizing and/or characterizing a user interface. The systems and methods include generating acoustic data associated with an acoustic reflection of an acoustic signal, the acoustic reflection being indicative of, at least in part, one or more features of a user interface coupled to a respiratory therapy device via a conduit. The systems and methods further include analyzing the generated acoustic data. The systems and methods further include categorizing and/or characterizing the user interface based, at least in part, on the analyzed acoustic data.

Abstract: A method of detecting rainout in a respiratory therapy system that includes a conduit fluidly coupled to a user interface comprises generating, via at least one microphone, acoustic data representative of noise associated with the respiratory therapy system. The method further comprises analyzing the acoustic data to detect a presence of liquid in the respiratory therapy system. The method further comprises causing an action to be performed, based on the detected presence of the liquid.

Abstract: Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.