Patents by Inventor Andrew Fraley

Andrew Fraley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for ADAR-Mediated Editing
    Publication number: 20250034563
    Abstract: The present invention relates to methods and compositions for editing a polynucleotide, e.g., a polynucleotide comprising a SNP associated with a disease or disorder.
    Type: Application
    Filed: June 28, 2022
    Publication date: January 30, 2025
    Inventors: Mallikarjuna Reddy Putta, Stephen V. Su, Andrew Fraley, Stuart Milstein, Duncan Brown
  • Methods and Compositions for ADAR-Mediated Editing
    Publication number: 20250034564
    Abstract: The present invention relates to methods and compositions for editing a polynucleotide, e.g., a polynucleotide comprising a SNP associated with a disease or disorder.
    Type: Application
    Filed: June 28, 2022
    Publication date: January 30, 2025
    Inventors: Mallikarjuna Reddy Putta, Stephen V. Su, Andrew Fraley, Stuart Milstein, Duncan Brown
  • Methods and Compositions for Adar-Mediated Editing
    Publication number: 20240263177
    Abstract: The present invention relates to methods and compositions for editing a polynucleotide. e.g., a polynucleotide comprising a SNP associated with a disease or disorder.
    Type: Application
    Filed: May 19, 2022
    Publication date: August 8, 2024
    Inventors: Andrew Fraley, Mallikarjuna Reddy Putta, Stuart Milstein, James M. Coull
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF LEUCINE RICH REPEAT KINASE 2 (LRRK2)
    Publication number: 20230295664
    Abstract: The present invention relates to methods and compositions for editing an LRRK2 polynucleotide, e.g., an LRRK2 polynucleotide comprising a SNP associated with Parkinson's Disease. The invention also relates to methods and compositions for treating or preventing Parkinson's Disease in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: September 21, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE LYASE (ASL)
    Publication number: 20230295614
    Abstract: The present invention relates to methods and compositions for editing an ASL polynucleotide, e.g., an ASL polynucleotide comprising a SNP associated with argininosuccinate lyase deficiency. The invention also relates to methods and compositions for treating or preventing argininosuccinate lyase deficiency in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: September 21, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF METHYL-CPG BINDING PROTEIN 2 (MECP2)
    Publication number: 20230272376
    Abstract: The present invention relates to methods and compositions for editing a MECP2 polynucleotide, e.g., a MECP2 polynucleotide comprising a SNP associated with Rett syndrome. The invention also relates to methods and compositions for treating or preventing Rett syndrome in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 31, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF GAP JUNCTION PROTEIN BETA 2 (GJB2)
    Publication number: 20230272383
    Abstract: The present invention relates to methods and compositions for editing a GJB2 polynucleotide, e.g., a GJB2 polynucleotide comprising a SNP associated with autosomal recessive non-syndromic hearing loss. The invention also relates to methods and compositions for treating or preventing autosomal recessive non-syndromic hearing loss in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 31, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF RETINOCHISIN 1 (RS1)
    Publication number: 20230272384
    Abstract: The present invention relates to methods and compositions for editing an RS1 polynucleotide, e.g., an RS1 polynucleotide comprising a SNP associated with X-linked retinoschisis (XLRS). The invention also relates to methods and compositions for treating or preventing XLRS in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 31, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 (TMC1)
    Publication number: 20230272377
    Abstract: The present invention relates to methods and compositions for editing a TMC1 polynucleotide, e.g., a TMC1 polynucleotide comprising a SNP associated with autosomal recessive non-syndromic hearing loss. The invention also relates to methods and compositions for treating or preventing autosomal recessive non-syndromic hearing loss in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 31, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF ARGININOSUCCINATE SYNTHETASE (ASS1)
    Publication number: 20230257752
    Abstract: The present invention relates to methods and compositions for editing an ASS1 polynucleotide, e.g., an ASS1 polynucleotide comprising a SNP associated with Citrullinemia Type 1. The invention also relates to methods and compositions for treating or preventing Citrullinemia Type 1 in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: August 17, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF OTOFERLIN (OTOF)
    Publication number: 20230212569
    Abstract: The present invention relates to methods and compositions for editing an OTOF polynucleotide, e.g., an OTOF polynucleotide comprising a SNP associated with autosomal recessive non-syndromic hearing loss. The invention also relates to methods and compositions for treating or preventing autosomal recessive non-syndromic hearing loss in a subject.
    Type: Application
    Filed: November 14, 2022
    Publication date: July 6, 2023
    Inventors: Matthew Jarpe, Mallikarjuna Reddy Putta, Andrew Fraley
  • Methods and Compositions for the ADAR-Mediated Editing of ABCA4
    Publication number: 20230174989
    Abstract: The present invention relates to methods and compositions for editing an ABCA4 polynucleotide, e.g., an ABCA4 polynucleotide comprising a SNP associated with Stargardt Disease, type 1. The invention also relates to methods and compositions for treating or preventing Stargardt Disease, type 1, in a subject.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 8, 2023
    Applicant: Korro Bio, Inc.
    Inventors: Andrew Fraley, Mallikarjuna Reddy Putta, Matthew Jarpe
  • RNA-Editing Enzyme-Recruiting Oligonucleotides and Uses Thereof
    Publication number: 20220307027
    Abstract: The present disclosure features useful compositions and methods to recruit RNA editing enzymes and treat disorders for which deamination of an adenosine in an mRNA produces a therapeutic result, e.g., in a subject in need thereof.
    Type: Application
    Filed: March 24, 2022
    Publication date: September 29, 2022
    Applicant: Korro Bio, Inc.
    Inventors: Andrew Fraley, Mallikarjuna Reddy Putta
  • Methods and Compositions for the ADAR-Mediated Editing of SERPINA1
    Publication number: 20210380980
    Abstract: The present invention relates to methods and compositions for editing a SERPINA1 polynucleotide, e.g., a SERPINA1 polynucleotide comprising a SNP associated with alpha 1 antitrypsin deficiency. The invention also relates to methods and compositions for treating or preventing alpha 1 antitrypsin deficiency in a subject.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 9, 2021
    Applicant: Korro Bio, Inc.
    Inventors: Steven Robinette, Andrew Fraley, Mallikarjuna Reddy Putta
  • Macrocyclic compounds for inhibition of inhibitors of apoptosis
    Patent number: 9605022
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: March 28, 2017
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Robert M. Borzilleri, Yong Zhang, Michael Miller, Andrew Fraley