Patents by Inventor Andrew G. Cole

Andrew G. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240246886
    Abstract: A process for preparing an olefin stream for oligomerization comprises fractionating an olefin stream to provide a light gas stream and a olefin rich stream. Oxygenates are absorbed from the olefin rich stream into a water wash stream to provide an oxygenate rich water wash stream and a washed olefin stream. Oxygenates are then adsorbed from the washed olefin rich stream, so the deoxygenated stream can then be oligomerized.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Andrew Piotrowski, Ernest J. Boehm, John J. Senetar, Matthew C. Cole, Jeannie Mee Blommel, Christopher Procopi, Ian G. Horn, Andrew B. Chin
  • Publication number: 20240246889
    Abstract: A process for preparing an olefin stream for oligomerization comprises fractionating an olefin stream to provide an ethylene stream and a olefin rich stream. Acetylenes in the ethylene stream are converted to ethylene in the presence of hydrogen to provide a concentrated ethylene stream that can be oligomerized.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Andrew Piotrowski, Ernest J. Boehm, John J. Senetar, Matthew C. Cole, Jeannie Mee Blommel, Christopher Procopi, Ian G. Horn, Andrew B. Chin
  • Publication number: 20240247197
    Abstract: A process is provided for preparing a hydrocarbon stream for oligomerization. The process strips dimethyl ether from an olefin stream using a stripping column. Lighter olefins such as C3? olefins are also removed. The C4+ olefins can then be sent for further processing including selective hydrogenation followed by oligomerization.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Andrew Piotrowski, Ernest J. Boehm, John J. Senetar, Matthew C. Cole, Jeannie Mee Blommel, Christopher Procopi, Ian G. Horn, Andrew B. Chin
  • Publication number: 20240247196
    Abstract: A process for preparing an olefin stream for oligomerization comprises fractionating an olefin stream to provide a light gas stream and an olefin rich stream. Oxygenates are absorbed from the olefin rich stream into a water wash stream to provide an oxygenate rich water wash stream and a washed olefin stream. The washed olefin stream can then be oligomerized.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Andrew Piotrowski, Ernest J. Boehm, John J. Senetar, Matthew C. Cole, Jeannie Mee Blommel, Christopher Procopi, Ian G. Horn, Andrew B. Chin
  • Publication number: 20240246890
    Abstract: A process for preparing an olefin stream for oligomerization comprises fractionating an olefin stream to provide a light gas stream and a olefin rich stream. The olefin rich stream is selectively hydrogenated to convert diolefins to mono-olefins and provide a mono-olefin stream and oligomerizing the mono-olefin stream over an oligomerization catalyst to provide an oligomerized stream.
    Type: Application
    Filed: January 19, 2024
    Publication date: July 25, 2024
    Inventors: Andrew Piotrowski, Ernest J. Boehm, John J. Senetar, Matthew C. Cole, Jeannie Mee Blommel, Christopher Procopi, Ian G. Horn, Andrew B. Chin
  • Publication number: 20240246964
    Abstract: The present disclosure includes substituted 1-aryl-1?-heteroaryl compounds, substituted 1,1?-biheteroaryl compounds, analogues thereof, and compositions comprising the same. Such compounds and analogues comprises compounds of formula (I). In one aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the disclosure can be used to treat, ameliorate, and/or prevent cancer in a patient.
    Type: Application
    Filed: March 25, 2022
    Publication date: July 25, 2024
    Applicant: Arbutus Biopharma Corporation
    Inventors: Vijay Ahuja, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Gavin D. Heffernan, Ramesh Kakarla, Steven G. Kultgen, Duyan Nguyen, Seyma Ozturk, Jorge Quintero, Michael J. Sofia
  • Publication number: 20240228504
    Abstract: The present invention includes substituted tricyclic amides of formula (I), or a salt, solvate, prodrug, stereoisomer, tautomer, or isotopically labelled derivative thereof, or any mixtures thereof, and compositions comprising the same.
    Type: Application
    Filed: May 13, 2021
    Publication date: July 11, 2024
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Steven G. Kultgen, Eugen F. Mesaros, Michael J. Sofia
  • Publication number: 20230312481
    Abstract: The present disclosure includes certain substituted (phthalazin-1-ylmethyl)ureas, N-(phthalazin-1-ylmethyl)amides, and analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Application
    Filed: June 7, 2021
    Publication date: October 5, 2023
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Steven G. Kultgen, Eugen F. Mesaros, Michael J. Sofia
  • Patent number: 11773110
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: October 3, 2023
    Assignee: LIGAND PHARMACEUTICALS INCORPORATED
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Publication number: 20230295115
    Abstract: The present disclosure includes substituted isoquinolinylmethyl amides, or analogues thereof, and compositions comprising the same, that can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Application
    Filed: June 7, 2021
    Publication date: September 21, 2023
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Steven G. Kultgen, Eugen F. Mesaros, Michael J. Sofia
  • Publication number: 20230143612
    Abstract: The present invention includes substituted 1,1?-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 11, 2023
    Inventors: Vijay Ahuja, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Ramesh Kakarla, Sharon Marie Kirk, Duyan Nguyen, Seyma Ozturk, Jorge G. Quintero, Michael J. Sofia
  • Publication number: 20230108906
    Abstract: The present disclosure includes in one aspect substituted arylmethyl ureas, substituted heteroarylmethyl ureas, or analogues thereof, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 6, 2023
    Inventors: Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Steven G. Kultgen, Eugen F. Mesaros
  • Publication number: 20230083973
    Abstract: The present disclosure includes novel substituted cyclopropyl-2,2?-bipyrimidinyl compounds, and compositions comprising the same. In certain embodiments, the compounds of the disclosure can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.
    Type: Application
    Filed: July 31, 2020
    Publication date: March 16, 2023
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Dimitar B. Gotchev, Jorge Quintero, Michael J. Sofia
  • Publication number: 20230045421
    Abstract: The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat and/or prevent hepatitis B virus (HBV) infections in a patient.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 9, 2023
    Inventors: Andrew G. Cole, Yi Fan, Steven Kultgen, Eugen Mesaros
  • Patent number: 11566002
    Abstract: The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 31, 2023
    Assignee: Arbutus Biopharma Corporation
    Inventors: Andrew G. Cole, Steven Kultgen
  • Publication number: 20230019280
    Abstract: The present disclosure includes substituted isoindolinyl 2,2?-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 19, 2023
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Benjamin J. Dugan, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Jorge Quintero, Michael J. Sofia
  • Publication number: 20220125771
    Abstract: The present invention includes substituted polycyclic carboxylic acids, analogues thereof, and compositions comprising the same, which can be used to treat, ameliorate, and/or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) in a patient.
    Type: Application
    Filed: January 15, 2020
    Publication date: April 28, 2022
    Inventors: Shuai Chen, Andrew G. Cole, Bruce D. Dorsey, Yi Fan, Dimitar B. Gotchev, Ramesh Kakarla, Sharon Marie Kirk, Jorge Quintero, Michael J. Sofia
  • Publication number: 20220119413
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Application
    Filed: October 28, 2021
    Publication date: April 21, 2022
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram
  • Patent number: 11236055
    Abstract: The present invention relates to sulfonamide compounds of formula (I) and formula (II), or a pharmaceutically acceptable salt thereof. The present sulfonamide compounds are useful non-systemic TGR5 agonists that can be used to treat diabetic diseases in human. The present invention provides a pharmaceutical composition containing sulfonamide compounds of formula (I) and formula (II) and a method of making as well as a method of using same in treating patients inflicted with metabolic disorders by administering same. The compounds of the present invention may be used in combination with additional anti-diabetic drugs.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: February 1, 2022
    Assignee: VENENUM BIODESIGN, LLC
    Inventors: Chia-Yu Huang, Brian F. McGuinness, Dongchuan Shi, Steven G. Kultgen, Jeffrey J. Letourneau, James R. Beasley, Philip D. Stein, Andrew G. Cole
  • Patent number: 11186593
    Abstract: Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: November 30, 2021
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Koc-Kan Ho, David Diller, Jeffrey J. Letourneau, Brian F. McGuinness, Andrew G. Cole, David Rosen, Cornelis A. van Oeveren, Jason C. Pickens, Lin Zhi, Yixing Shen, Bijan Pedram