Patents by Inventor Andrew G. Myers
Andrew G. Myers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240089112Abstract: The invention relates to computer-implemented systems and methods for implementing a verified digital asset platform. An embodiment of the present invention is directed to enabling companies to provide professional recognition awards to employees utilizing digital assets, such as NFT (Non-Fungible Tokens). With an embodiment of the present invention, a digital wallet may store public and private keys and allow the owner to perform various actions including access assets, manage assets and sign transactions.Type: ApplicationFiled: September 14, 2023Publication date: March 14, 2024Inventors: Michal Pol, Sarah J. Bond, Greg Genega, Louis Goldberg, Jiseon Stephanie Kim, Victor Charles Melilli, Joshua Miller, Cory L. Myers, Nikola G. Ognjanovic, Anu Desireddi Puvvada, Edwige Sacco, Bryan Samek, Andrew Urban
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Patent number: 11767341Abstract: Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.Type: GrantFiled: September 8, 2021Date of Patent: September 26, 2023Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Matthew James Mitcheltree, Katherine J. Silvestre
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Publication number: 20230242565Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.Type: ApplicationFiled: April 4, 2023Publication date: August 3, 2023Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
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Publication number: 20230203081Abstract: Provided are compounds of Formula (I) for the treatment of infectious and inflammatory diseases. The compounds described herein are lincosamides modified at the amino acid (southern) region. The compounds may have further modification at the C-7 position of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of treating infectious diseases using the disclosed compounds.Type: ApplicationFiled: May 20, 2021Publication date: June 29, 2023Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Katherine J. Silvestre, Matthew James Mitcheltree, Giambattista Testolin, Jeremy D. Mason, Aditya Pote, Daniel Terwilliger
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Patent number: 11673910Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.Type: GrantFiled: April 27, 2018Date of Patent: June 13, 2023Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
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Patent number: 11634449Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: GrantFiled: December 4, 2020Date of Patent: April 25, 2023Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
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Publication number: 20230109357Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: ApplicationFiled: July 25, 2022Publication date: April 6, 2023Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
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Publication number: 20230093692Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.Type: ApplicationFiled: November 18, 2019Publication date: March 23, 2023Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Hogan Philip, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Andre Sanchez, Ganapathy Dhandapani, Thrimurtulu Neetipalli, Md. Ataur Rahman, Thomas Lepitre
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Patent number: 11566039Abstract: Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the C-7 position of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.Type: GrantFiled: August 10, 2018Date of Patent: January 31, 2023Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Matthew James Mitcheltree
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Patent number: 11535643Abstract: Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.Type: GrantFiled: April 8, 2020Date of Patent: December 27, 2022Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
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Publication number: 20220332747Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: ApplicationFiled: December 4, 2020Publication date: October 20, 2022Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
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Patent number: 11466046Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: GrantFiled: April 8, 2020Date of Patent: October 11, 2022Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
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Publication number: 20220306673Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.Type: ApplicationFiled: April 27, 2018Publication date: September 29, 2022Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra llandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
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Publication number: 20220177508Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.Type: ApplicationFiled: November 18, 2019Publication date: June 9, 2022Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Vijaya Gondi, Philip Hogan, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Md. Ataur Rahman
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Publication number: 20220073554Abstract: Provided are lincosamide compounds for the treatment of infectious diseases. The lincosaniides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.Type: ApplicationFiled: September 8, 2021Publication date: March 10, 2022Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Matthew James Mitcheltree, Katherine J. Silvestre
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Patent number: 11192866Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.Type: GrantFiled: May 20, 2019Date of Patent: December 7, 2021Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel
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Patent number: 11124534Abstract: Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.Type: GrantFiled: August 10, 2018Date of Patent: September 21, 2021Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Matthew James Mitcheltree, Katherine J. Silvestre
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Patent number: 11008358Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A?) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D?) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.Type: GrantFiled: December 23, 2019Date of Patent: May 18, 2021Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ziyang Zhang
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Publication number: 20210087215Abstract: Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the C-7 position of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamycin. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.Type: ApplicationFiled: August 10, 2018Publication date: March 25, 2021Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Matthew James Mitcheltree
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Patent number: 10913764Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: GrantFiled: April 5, 2018Date of Patent: February 9, 2021Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang