Abstract: Described herein are methods and compositions for the targeted delivery of selective delivery molecule therapeutic agents and imaging agents.

Abstract: Described herein are methods and compositions for the targeted delivery of therapeutic agents and imaging agents.

Abstract: The present application generally relates to methods to prevent or treat bleeding and/or hypocoagulation in an individual in need thereof, and compositions for use in such methods. The methods comprise administration of FVa, preferably an APC resistant FVa (such as superFVa), alone or in combination with FVIIa, preferably rhFVIIa (such as NovoSeven® or another FVIIa having enhanced activity or half-life). When administered in combination, FVa and FVIIa elicit a synergistic benefit when used to treat or prevent bleeding or hypocoagulation in subjects in need thereof, e.g.

Abstract: A multicore system controls devices in a process control system. A primary control processing device having a primary master core and a primary remote core is configured for controlling communications on a first network among a first plurality of devices. The primary remote core is configured for controlling communications on a second network among a second plurality of devices. A shadow control processing device is coupled to the first and second networks for processing redundant communications among the devices. The shadow control processing device comprises a shadow master core and a shadow remote core. The shadow master core is configured for controlling communications on the first network among the first plurality of devices. The shadow remote core is configured for controlling communications on the second network among the second plurality of devices.

Abstract: A multicore system controls devices in a process control system. A primary control processing device having a primary master core and a primary remote core is configured for controlling communications on a first network among a first plurality of devices. The primary remote core is configured for controlling communications on a second network among a second plurality of devices. A shadow control processing device is coupled to the first and second networks for processing redundant communications among the devices. The shadow control processing device comprises a shadow master core and a shadow remote core. The shadow master core is configured for controlling communications on the first network among the first plurality of devices. The shadow remote core is configured for controlling communications on the second network among the second plurality of devices.

Abstract: The present application generally relates to methods to prevent or treat bleeding and/or hypocoagulation in an individual in need thereof, and compositions for use in such methods. The methods comprise administration of FVa, preferably an APC resistant FVa (such as superFVa), alone or in combination with FVIIa, preferably rhFVIIa (such as NovoSeven® or another FVIIa having enhanced activity or half-life). When administered in combination, FVa and FVIIa elicit a synergistic benefit when used to treat or prevent bleeding or hypocoagulation in subjects in need thereof, e.g.

Abstract: There is disclosed herein a vehicle configuration comprising a chassis, at least one front wheel, two rear wheels, and a propulsion unit driving the rear wheels. The rear wheels are connected to the chassis by a wheel support assembly configured for allowing movement of each rear wheel relative to the chassis, a hydraulic cylinder connected to the chassis and the rear wheel supports, and a piston connected the rear wheel supports and the chassis. The piston dividing the hydraulic cylinder into fluidly connected first and second chambers such that movement of hydraulic fluid from the first or second chamber of a hydraulic cylinder to the respective first or second chamber of another hydraulic cylinder displaces the pistons of the hydraulic cylinders in opposing directions relative to the respective housings and causes the chassis to articulate with respect to the surface.

Abstract: There is provided a vehicle comprising a chassis, two surface-engaging front wheels, at least one surface-engaging rear wheel and a propulsion unit for driving either the front wheels or the rear wheel or wheels. Each front wheel being connected to the chassis by means of a front wheel support assembly, wherein the front wheel support assembly comprises a hydraulic cylinder associated with each front wheel. Each hydraulic cylinder comprises a housing connected to one of the chassis and the front wheel support assembly, and a piston connected to the other of the front wheel support assembly and the chassis.

Abstract: There is provided a vehicle comprising a chassis, two surface-engaging front wheels, at least one surface-engaging rear wheel and a propulsion unit for driving either the front wheels or the rear wheel or wheels. Each front wheel being connected to the chassis by means of a front wheel support assembly, wherein the front wheel support assembly comprises a hydraulic cylinder associated with each front wheel. Each hydraulic cylinder comprises a housing connected to one of the chassis and the front wheel support assembly, and a piston connected to the other of the front wheel support assembly and the chassis.

Abstract: There is disclosed herein a vehicle configuration comprising a chassis, at least one front wheel, two rear wheels, and a propulsion unit driving the rear wheels. The rear wheels are connected to the chassis by a wheel support assembly configured for allowing movement of each rear wheel relative to the chassis, a hydraulic cylinder connected to the chassis and the rear wheel supports, and a piston connected the rear wheel supports and the chassis. The piston dividing the hydraulic cylinder into fluidly connected first and second chambers such that movement of hydraulic fluid from the first or second chamber of a hydraulic cylinder to the respective first or second chamber of another hydraulic cylinder displaces the pistons of the hydraulic cylinders in opposing directions relative to the respective housings and causes the chassis to articulate with respect to the surface.

Abstract: A method and network access point selection logic are described for a redundantly connected industrial LAN node including at least primary and backup network access points. Network connectivity is determined by a redundantly connected node by testing connectivity between the node's primary and backup physical network access points. Upon detecting a loss of connectivity between the redundant node's primary and backup network access points, the node executes access point selection logic, based upon tests of connectivity between the redundantly connected (primary and backup) network access points and a set of nodes on the LAN, to select a preferred/primary one of the redundant access points. Thereafter, the redundantly connected node binds its connections according to primary and backup designations for its redundant network access points.

Abstract: The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. The invention also relates to polypeptides containing such introduced cysteine residue(s), nucleic acids encoding such polypeptides and pharmaceutical compositions comprising such polypeptides or nucleic acids. The invention also relates to vectors, viral particles and host cells containing such nucleic acids, and methods of using them to produce the polypeptides of the invention. Exemplified polypeptides include plasma proteins, including hepatocyte growth factor activator and plasma hyaluronin binding protein, as well as blood coagulation factors, such as Factor VIII, Factor V, Factor XII and prothrombin.

Abstract: Variants (mutants) of recombinant activated protein C (APC) or recombinant protein C (prodrug, capable of being converted to APC) that have substantial reductions in anticoagulant activity but that retain normal levels of anti-apoptotic activity are provided. Three examples of such recombinant APC mutants are KKK191-193AAA-APC, RR229/230AA-APC, and RR229/230AA plus KKK191-193AAA-APC. APC variants and prodrugs of the invention have the desirable property of being cytoprotective (anti-apoptotic effects), while having significantly reduced risk of bleeding. The invention also provides a method of using the APC variants or prodrugs of the invention to treat subjects who will benefit from APC's cytoprotective activities that are independent of APC's anticoagulant activity. These subjects include patients at risk of damage to blood vessels or tissue in various organs caused, at least in part, by apoptosis.

Abstract: Variants (mutants) of recombinant activated protein C (APC) or recombinant protein C (prodrug, capable of being converted to APC) that have substantial reductions in anticoagulant activity but that retain normal levels of anti-apoptotic activity are provided. Two examples of such recombinant APC mutants are KKK191-193AAA-APC and RR229/230M-APC. APC variants and prodrugs of the invention have the desirable property of being cytoprotective (anti-apoptotic effects), while having significantly reduced risk of bleeding. The invention also provides a method of using the APC variants or prodrugs of the invention to treat subjects who will benefit from APC's cytoprotective activities that are independent of APC's anticoagulant activity. These subjects include patients at risk of damage to blood vessels or tissue in various organs caused, at least in part, by apoptosis.

Abstract: The present invention provides a method of credit aggregation in an arrangement including a borrower, a plurality of credit suppliers, and a credit aggregator, the method including the steps of: determining a borrower's credit requirements; assessing offers of credit from the credit suppliers to determine a suitable combination of credit offers to meet the needs of the borrower; the credit aggregator entering into at least one agreement with the borrower to provide the suitable combination of offers; the credit aggregator entering into separate agreements with each of the credit suppliers in relation to the relevant parts of each offer to supply credit to the borrower; wherein the arrangement of credit facilities are supplied by the credit suppliers to the borrower without the borrower entering into an agreement with the individual credit suppliers.

Abstract: A method for manufacturing a Personal Computer Memory Common Interface Architecture (“PCMCIA”) printed circuit board (“PCB”) includes providing a PCB having a PCMCIA area and an auxiliary area. The PCMCIA area has multiple locations adapted to receive electronic components. The auxiliary area has multiple test points disposed thereon. The method also includes populating the PCMCIA area with electronic components. Testing of the PCMCIA area is next performed by electrically contacting at least some of the multiple test points within said auxiliary area. If the testing produces unsatisfactory results, diagnostics and repair are performed. After the testing produces satisfactory results, the auxiliary area is separated from the PCMCIA area to produce a populated, tested, PCMCIA PCB.

Abstract: Information is transmitted to a network by a system which receives data from a first processor into a first FIFO and from a second processor into a second FIFO. Data exiting the first FIFO is discarded. As data is received into second FIFO, data exiting the FIFO is transferred to the network. When and end-of-message indication is detected in the received data, the contents of the FIFOs are compared. If a miscompare occurs, transferred data from the second FIFO to the network is caused to be in error. Accordingly, a message sent to the network from the second FIFO will be rejected either by the network or by a receiving node.

Abstract: Spectacle lenses are coated by ion vapor deposition by means of sputtering target materials. A plurality of lenses to be coated are introduced into a sputtering chamber by a load lock device, and when in the chamber the lenses are covered by a disc which is rotated at high speed (50/60 rpm). During this rotation alternate targets of magnetrons are sputtered releasing metal particles which are oxidized by an oxygen plasma created by a third magnetron and metallic oxide coatings are formed on the lenses as alternate layers of different materials. At the end of the operation of coating, which is pre-programmed, the lenses are returned automatically to the load lock device from whence they can be removed. After placement or the lenses in the load lock device the entire process is effected automatically by pressing a button.