Abstract: The disclosed computer-implemented method for improving the classification accuracy of trustworthiness classifiers may include (1) identifying a set of training data that is available for training trustworthiness classifiers used to classify computing resources as clean or malicious, (2) selecting, based at least in part on a characteristic of a specific organization, a subset of training data from the set of training data that is available for training trustworthiness classifiers, (3) training a trustworthiness classifier for the specific organization using the subset of training data selected based at least in part on the characteristic of the specific organization, and then (4) applying the trustworthiness classifier to at least one computing resource encountered by the specific organization to classify the computing resource as clean or malicious. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.

Abstract: Disclosed herein is a lens for a wearable projection system. The lens includes a lens blank and a holographic optical element. The holographic optical element can be removably attached to the lens. The holographic optical element is aligned to a position on the lens surface based on temporary alignment marks projected onto the lens.

Abstract: There is described a method of establishing an electrical connection through a flexible planar material. The method involves attaching an intermediate coupling element to the flexible planar material so as to align an aperture defined by the intermediate coupling element with a hole through the flexible planar material, and coupling an electrical connector to the intermediate coupling element so as to permit electrical connection through the flexible planar material. In this way, the intermediate coupling element can be attached to the garment during the garment manufacture process, and subsequently the electrical connector can be coupled to the intermediate coupling element separately from the main garment manufacture.

Abstract: There is described a connector assembly having a first connector part and a second connector part. At least one of the first connector part and the second connector part comprises at least one magnet for providing an attractive force between the first connector part and the second connector part to align the first connector part and the second connector part in a connected state. The first connector part comprises a guide track and the second connector part comprises a follower, the guide track being shaped to guide movement of the follower, under the influence of said attractive force, to a retaining position in which the follower engages an abutment surface on the first connector part to provide a retaining mechanism for retaining the first connector part and the second connector part in the connected state.

Abstract: A modular magnet writing instrument and hobby tool comprises a plurality of permanent magnet segments and a writing cartridge. Each magnet segment is magnetized axially. An aperture extends longitudinally through the entirety of each magnet segment. The writing cartridge has an elongate body, which is sized for coaxial insertion within a magnet segment, or plurality of magnet segments, such that the magnet segments are in sliding engagement with the elongate body. In operation, different combinations of magnet segments can be axially positioned on the elongate body, in a variety of like-pole and unlike-pole interactions, to produce a plurality of writing and hobby tool configurations.

Abstract: This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.

Abstract: This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.

Abstract: Suspicious file prospecting activity is detected based on patterns of file system access. A user's file system access is monitored over a specific time period. A sequence of the file accesses (e.g., represented as path names) made by the user during the time period is recorded. Distances between the recorded file accesses are determined, for example as edit distances. A distance sequence is recorded, comprising a record of the determined distances. The distance sequence is reduced to one or more baseline statistics describing the pattern of the user's access of the file system during the given period of time. At least one subsequent anomaly in the user's access of the file system is detected, by comparing at least one subsequently calculated statistic representing at least one subsequent pattern of the user's file system access to the at least one baseline statistic.

Abstract: This disclosure provides, among other things, a composition comprising: a 5? exonuclease; a strand-displacing polymerase; and optionally a single strand DNA binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described.

Abstract: This disclosure provides, among other things, a composition comprising: comprising a fusion protein comprising: (a) a DNA polymerase; and (b) a heterologous sequence-specific DNA binding domain. A method for copying a DNA template, as well as a kit for performing the same, are also described.

Abstract: This disclosure provides, among other things, a composition comprising: a 5? exonuclease; a strand-displacing polymerase; and optionally a single strand DNA binding protein and/or a ligase. A method for polynucleotide assembly to form a synthon, as well as a kit for performing the same, are also described.

Abstract: A modular magnet writing instrument and hobby tool comprises a plurality of permanent magnet segments and a writing cartridge. Each magnet segment is magnetized axially. An aperture extends longitudinally through the entirety of each magnet segment. The writing cartridge has an elongate body, which is sized for coaxial insertion within a magnet segment, or plurality of magnet segments, such that the magnet segments are in sliding engagement with the elongate body. In operation, different combinations of magnet segments can be axially positioned on the elongate body, in a variety of like-pole and unlike-pole interactions, to produce a plurality of writing and hobby tool configurations.

Abstract: Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo?” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic DNA polymerase.

Abstract: Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo?” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic DNA polymerase.

Abstract: Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo?” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic DNA polymerase.

Abstract: Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo?” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic DNA polymerase.

Abstract: A limb support comprising a first portion for supporting the lower part of a patient's lower limb, a second portion for supporting the upper part of the patient's lower limb, each portion with deep guttering suitable for providing rotational and angulatory support to the portion of the limb, an adjustable support, and surface engaging portions comprising the adjustable support and free end of the second portion.

Abstract: Compositions and methods are provided that relate to a recombinant protein with DNA polymerase activity in which one or more amino acids are mutated compared with the corresponding wild type protein. The recombinant protein is capable of incorporating one or more modified nucleotides into a nucleic acid substrate with a specific activity greater than 200.