Patents by Inventor Andrew Garst

Andrew Garst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200399584
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: September 4, 2020
    Publication date: December 24, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • Nucleic acid-guided nucleases
    Patent number: 10870841
    Abstract: The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.
    Type: Grant
    Filed: August 9, 2020
    Date of Patent: December 22, 2020
    Assignee: Inscripta, Inc.
    Inventors: Benjamin Mijts, Aamir Mir, Andrew Garst, Juhan Kim, Kyle Seamon
  • CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING
    Publication number: 20200392539
    Abstract: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.
    Type: Application
    Filed: July 24, 2020
    Publication date: December 17, 2020
    Inventors: Andrew Garst, Ryan T Gill
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10851339
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: December 1, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10844344
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: November 24, 2020
    Assignee: Inscripta, Inc.
    Inventors: Andrew Garst, Richard Fox, Phillip Belgrader, Don Masquelier
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10835869
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: November 17, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Matthew Estes, Bruce Chabansky, Andrew Garst, Richard Fox, Jorge Bernate
  • ENGINEERED ENZYMES
    Publication number: 20200354703
    Abstract: The present disclosure provides engineered RNA-guided enzymes for editing live cells.
    Type: Application
    Filed: April 9, 2020
    Publication date: November 12, 2020
    Inventors: Benjamin Mijts, Juhan Kim, Aamir Mir, Kyle Seamon, Andrew Garst
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200347342
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: July 15, 2020
    Publication date: November 5, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200346168
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: July 14, 2020
    Publication date: November 5, 2020
    Inventors: Phillip Belgrader, Don Masquelier, Matthew Estes, Bruce Chabansky, Andrew Garst, Richard Fox, Jorge Bernate
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10801008
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: October 13, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • Nucleic acid-guided nucleases
    Patent number: 10767169
    Abstract: The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: September 8, 2020
    Assignee: Inscripta, Inc.
    Inventors: Juhan Kim, Benjamin Mijts, Aamir Mir, Andrew Garst, Kyle Seamon
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10760043
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: September 1, 2020
    Assignee: Inscripta, Inc.
    Inventors: Andrew Garst, Richard Fox, Phillip Belgrader, Don Masquelier
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10752874
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: August 25, 2020
    Assignee: Inscripta, Inc.
    Inventors: Charles Johnson, Miles Gander, Don Masquelier, Phillip Belgrader, Andrew Garst, Matthew Estes, Bruce Chabansky, Jorge Bernate
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10744463
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: August 18, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Matthew Estes, Bruce Chabansky, Andrew Garst, Richard Fox, Jorge Bernate
  • Nucleic acid-guided nucleases
    Patent number: 10745678
    Abstract: The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: August 18, 2020
    Assignee: Inscripta, Inc.
    Inventors: Juhan Kim, Benjamin Mijts, Aamir Mir, Andrew Garst, Kyle Seamon
  • INSTRUMENTS, MODULES, AND METHODS FOR IMPROVED DETECTION OF EDITED SEQUENCES IN LIVE CELLS
    Publication number: 20200248131
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Application
    Filed: March 16, 2020
    Publication date: August 6, 2020
    Inventors: Andrew Garst, Richard Fox, Phillip Belgrader, Don Masquelier
  • CRISPR enabled multiplexed genome engineering
    Patent number: 10731180
    Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Andrew Garst, Ryan T. Gill
  • Instruments, modules, and methods for improved detection of edited sequences in live cells
    Patent number: 10723995
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 28, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Andrew Garst, Richard Fox
  • Nucleic acid-guided nucleases
    Patent number: 10724021
    Abstract: The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: July 28, 2020
    Assignee: Inscripta, Inc.
    Inventors: Juhan Kim, Benjamin Mijts, Aamir Mir, Andrew Garst, Kyle Seamon
  • NUCLEIC ACID-GUIDED NUCLEASES
    Publication number: 20200231987
    Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 23, 2020
    Inventors: Andrew Garst, Ryan T. Gill, Tanya Elizabeth Warnecke Lipscomb