Abstract: Systems and methods for entropy-based treatment in accordance with embodiments of the invention are illustrated. One embodiment includes a method for treating a neurological condition, including obtaining a functional magnetic resonance imaging (fMRI) scan of a patient's brain, identifying a plurality of regions of interest (ROIs) in the fMRI scan, calculating entropy metrics for each ROI in the plurality of ROIs, selecting a treatment from a plurality of treatments for the neurological condition based on the entropy metrics, and provide the selected treatment to the patient. In a further embodiment, calculating entropy metrics includes generating multiscale entropy curves for each ROI, calculating the area under each entropy curve, assigning each ROI as positive or negative sign based on the entropy curve of each ROI, generating a similarity index for each ROI, and signing the similarity index for each ROI using the assigned sign of each ROI.