Abstract: A composite oxidation catalyst for use in an exhaust system for treating an exhaust gas produced by a vehicular compression ignition internal combustion engine is disclosed. The composite oxidation catalyst comprises a honeycomb flow-through substrate monolith and two catalyst washcoat zones arranged axially in series on and along the substrate surface.

Abstract: The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

Abstract: The current disclosure provides methods and systems for increasing an accuracy and/or suitability of an automated measurement of a medical image. In one embodiment, the current disclosure provides for a method comprising: receiving one or more user-selected measurement points for an automated measurement of an anatomical feature of a medical image from a user; predicting one or more additional measurement points for the automated measurement based on the one or more user-selected measurement points and based on a comparison of the anatomical feature of the medical image with a plurality of images of the anatomical feature via a trained network; and performing the automated measurement of the anatomical feature based at least on the one or more additional measurement points.

Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable alkanesulphonate salt thereof, that is a clear solution. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: A system and method is provided for obtaining ultrasound images of an interior of an object that includes an image processing unit that receives and processes acquired ultrasound scan data to create ultrasound images derived from ultrasound image data, a motion detection system configured to detect a pattern of inactivity time frames within movement cycles of the object and an ultrasound imaging probe operably connected to the image processing unit to acquire the ultrasound scan data for use by the image processing unit to form the ultrasound images. The motion detection system detects a pattern of one or more inactivity time frames within a first cycle of movement of the object, obtains ultrasound volumetric scan data of the object during the inactivity time frame within a second cycle of movement of the object, and calibrates a location of a scan plane of the ultrasound image within the volumetric ultrasound image.

Abstract: Methods and systems are provided for identifying shape-based atypical segmentations. In one example, a method includes receiving a segmentation of a region of interest (ROI) of a medical image, the segmentation output by a segmentation model, calculating a confidence metric of the segmentation that indicates how well a shape of the segmentation can be encoded by an encoding of one or more principal modes of shape variation of a set of previously determined segmentations of the ROI, and responsive to the confidence metric meeting a predetermined condition relative to a threshold, displaying the segmentation, storing the segmentation, and/or using the segmentation in one or more downstream processes; otherwise, prompting a user to perform a manual segmentation.

Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable alkanesulphonate salt thereof, that is a clear solution. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: The current disclosure provides methods and systems for increasing an accuracy and/or suitability of an automated measurement of a medical image. In one embodiment, the current disclosure provides for a method comprising: receiving one or more user-selected measurement points for an automated measurement of an anatomical feature of a medical image from a user; predicting one or more additional measurement points for the automated measurement based on the one or more user-selected measurement points and based on a comparison of the anatomical feature of the medical image with a plurality of images of the anatomical feature via a trained network; and performing the automated measurement of the anatomical feature based at least on the one or more additional measurement points.

Abstract: An automated measurement system for an ultrasound and/or echocardiographic imaging system enhances reproducibility of measurement results and accommodates form movement in the measurement of the images by combining measurements across multiple cardiac cycles/multiple echocardiogram images. The automated system provides these benefits by initially selecting the cardiac images/cycles for which valid measurements can be obtained within constraints defined by the automated system. With these selected cycles, the automated system then combines the measurements from the selected cycles into a global measurement for the desired parameter or parameters for the combined cycles.

Abstract: Provided is a system for autonomous control of dynamical systems. The system may include one or more processors programmed or configured to receive data associated with a host platform, construct a run-time dynamic envelope based on the data associated with the host platform, and construct a Worldview Relational Interaction Map (WRIM) based on the run-time dynamic envelope, wherein the WRIM comprises a coordinate system corresponding to an area (e.g., a volume associated with the area) of an environment of the host platform, wherein the coordinate system comprises a plurality of elements, wherein each element of the plurality of elements includes one or more data attributes associated with a predicted momentum exchange resulting from the host platform co-occupying the element with an entity. A method and computer program product are also disclosed.

Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable alkanesulphonate salt thereof, that is a clear solution. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: A vehicle sensor calibration system can detect an SDV on a turntable surrounded by a plurality of fiducial targets, and rotate the turntable using a control mechanism to provide the sensor system of the SDV with a sensor view of the plurality of fiducial targets. The vehicle sensor calibration system can receive, over a communication link with the SDV, a data log corresponding to the sensor view from the sensor system of the SDV recorded as the SDV rotates on the turntable. Thereafter, the vehicle sensor calibration system can analyze the sensor data to determine a set of calibration parameters to calibrate the sensor system of the SDV.

Abstract: Fluid-dispensing systems and methods relating thereto are described. A method of dispensing an output fluid stream includes: (i) receiving a temperature setting for a desired temperature of the output fluid stream and a mechanical disturbance for a desired flow rate of the output fluid stream; (ii) converting each of the temperature setting and the mechanical disturbance to a first valve PWM signal and a second valve PWM signal; (iii) conveying the first PWM signal to a first motor and the second PWM signal to a second motor; and (iv) activating the first motor to open the first valve to produce a first fluid flow at a first fluid flow rate and second motor and the first motor to open the second valve to produce a first fluid flow at a first fluid flow rate. The combination of the first fluid flow and the second fluid flow produces the desired output fluid stream.

Abstract: The present invention relates to a pharmaceutical aqueous formulation comprising 1-(4-{[4-(dimethylamino)piperidin-1-enyl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, or a pharmaceutically acceptable organic or inorganic acid salt thereof, a pharmaceutically acceptable organic or inorganic acid, a pharmaceutically acceptable beta- or gamma-cyclodextrin and water, that is a clear solution, with the proviso that the organic or inorganic acid (including a salt thereof) is not a sulphonic acid. Such a formulation is particularly suitable for intravenous or parenteral administration to a patient.

Abstract: A vehicle sensor calibration system for self-driving vehicles can include a turntable on which a sensor system including a LIDAR sensor is positioned. A plurality of fiducial targets can be positioned around the turntable to enable calibration of the sensor system, and a control mechanism can automatically rotate the turntable when the sensor system is positioned on the turntable. The system can include one or more computing systems that receive a data log corresponding to sensor data recorded by the sensor system as the sensor system rotates on the turntable, and analyze the sensor data to determine a set of calibration parameters to calibrate the sensor system.

Abstract: A vehicle sensor calibration system for self-driving vehicles can include a turntable on which a sensor system including a LIDAR sensor is positioned. A plurality of fiducial targets can be positioned around the turntable to enable calibration of the sensor system, and a control mechanism can automatically rotate the turntable when the sensor system is positioned on the turntable. The system can include one or more computing systems that receive a data log corresponding to sensor data recorded by the sensor system as the sensor system rotates on the turntable, and analyze the sensor data to determine a set of calibration parameters to calibrate the sensor system.

Abstract: Systems, methods, and other embodiments associated with load prediction using load profiles are described. In one embodiment, a method includes receiving weather information for a plurality of geographical regions, and receiving load information from a plurality of meters located in the plurality of geographical regions. A load profile is generated for each of the geographical regions. Each load profile is generated based upon (i) weather information corresponding to a geographical region and (ii) load information corresponding to one or more meters located within the geographical region. A loading is predicted for each geographical region based upon a load profile for the geographical region. A determination is made as to whether the predicted loading for each geographical region exceeds a defined threshold. In response to a first predicted loading for a first geographical region exceeding the defined threshold, a geographical representation of the first geographical region is distinguished.

Abstract: Methods and systems are presented to transport and store personal cargo in a secure seasonal portable closet or similar large portable locker configured to roll through a standard domestic doorway. Such lockers may be configured with several posts, wheels supporting one or more frames, and a sleeve assembly or other security covering supported by the posts.

Abstract: A vehicle sensor calibration system for self-driving vehicles can include a turntable on which a sensor system including a LIDAR sensor is positioned. A plurality of fiducial targets can be positioned around the turntable to enable calibration of the sensor system, and a control mechanism can automatically rotate the turntable when the sensor system is positioned on the turntable. The system can include one or more computing systems that receive a data log corresponding to sensor data recorded by the sensor system as the sensor system rotates on the turntable, and analyze the sensor data to determine a set of calibration parameters to calibrate the sensor system.

Abstract: Methods and systems are presented to transport and store personal cargo in a secure seasonal portable closet or similar large portable locker configured to roll through a standard domestic doorway. Such lockers may be configured with several posts, wheels supporting one or more frames, and a sleeve assembly or other security covering supported by the posts.