Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: There is provided a new and improved synthetic route for the synthesis of the compound 1-{2-[(1R)-1-aminoethyl]-4-chlorobenzyl}-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one (Formula (I)) that is readily scalable for commercial production. Also provided are important intermediate compounds that are formed in the new and improved synthetic route for the synthesis of the compound of formula (I).

Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: A system and method of using a tool assembly is provided. The system includes a body, a first camera and a second camera fixed to the body, and a controller. The controller is configured to receive data indicative of images of a reference feature from the first camera, determine data indicative of a first spatial position of the first camera based at least in part on the received data indicative of the images of the reference feature, and determine data indicative of a second spatial position of the second camera based on the first spatial position, a known spatial relationship between the first location and the second location, or both. Further, the controller may be configured to receive data indicative of images of a target feature using the second camera, derive dimensions of the target feature based on the images, and generate a three-dimensional representation of the target feature.

Abstract: An electronic sports playbook and video annotation system includes a device with a memory coupled to a processor that stores instructions that, when executed by the processor, cause the processor to generate sports playbook content based on coordinate or image data. The processor is configured to detect an object (e.g., a player, etc.) on a surface (e.g., court image, or play image such as a static play drawing or video recording frame), detect a drawing of a path relating to the object (e.g., by user input device or with image processing, machine learning, or other heuristic techniques, etc.), and determine an action (e.g., a pass, dribble, cut, screen, handoff, etc.) associated with the object based on at least an attribute of the object (e.g., does the player have possession?, etc.) and detected path relating to the object. Devices may generate memory games from sports playbook content.

Abstract: An apparatus for processing magnetite iron ore, including a screen arranged to send oversize material to a regrind mill and undersize material to a high grade concentrate thickener and includes a CCD thickener type system for product grade improvements.

Abstract: A battery-powered device comprising a power input providing power to the device is described herein, with a housing having an opening for receiving a smartcard. There may be at least one electrical contact within the housing, the at least one electrical contact connected to the power input. There is also provided a power supply for one or more battery-powered devices each having at least one electrical contact within a housing configured to make contact with a smartcard introduced into an opening in the housing, the power supply comprising a power input (e.g., a wire or circuit). There may be an electrical output connected to the power input.

Abstract: An electronic sports playbook and video annotation system includes a device with a memory coupled to a processor that stores instructions that, when executed by the processor, cause the processor to generate sports playbook content based on coordinate or image data. The processor is configured to detect an object (e.g., a player, etc.) on a surface (e.g., court image, or play image such as a static play drawing or video recording frame), detect a drawing of a path relating to the object (e.g., by user input device or with image processing, machine learning, or other heuristic techniques, etc.), and determine an action (e.g., a pass, a dribbling, a cut, a screen, a handoff, etc.) associated with the object based on at least an attribute of the object (e.g., does the player have the ball?, etc.) and detected path relating to the object.

Abstract: A method and system are provided for managing cybersecurity vulnerabilities of resources within at least one network. The method includes collecting data including application risk rank and network location. The method further includes determining a vulnerability score for vulnerabilities of the resources and determining severity score based on the application risk rank and network location. The method additionally includes integrating the vulnerability score and the severity score to create a two-dimensional risk ranking.

Abstract: A method of controlling the robotic floor cleaning machine is disclosed that includes sensing, by a sensor on the robotic cleaning machine, an object within a sensed field. The method further includes determining, by a safety controller on the robotic cleaning machine, whether the object is an immovable object (such as a wall), and deploying an extendable cleaning element to clean the floor surface up next to the wall. The method can further include deploying the extendable cleaning element such that the extendable cleaning element is in contact with and cleans the floor up to an edge of the immovable object. Additionally, the method can include determining that the object is a movable object (such as a living thing) and preventing the extendable cleaning element from extending such that the robotic cleaning machines does not contact the movable object.

Abstract: A system includes a view screen with polarized output. The view screen may include a projected view screen or writing-surface view screen. A window capable of blocking the polarized output at least in part cloaks the view screen to frustrate viewing of the view screen through the window. In some cases, the window includes an array of panels capable of blocking multiple polarizations. The array may disrupt multiple different polarized view screen outputs while maintaining transparency to unpolarized light. In some cases, the window capable of blocking polarized output may be paired with view screen cover that converts view screen output in an unblocked polarization to one of the one or more polarizations blocked by the window.

Abstract: The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

Abstract: A method of controlling a robotic floor cleaning machine includes driving, by an operator, the robotic floor cleaning machine along a transport path and a cleaning path. The transport path defines a path for transport of the robotic floor cleaning machine without active cleaning and the cleaning path defines a path for a cleaning operation. The method further includes recording the transport path and the cleaning path driven by the operator; defining, in a controller of the robotic floor cleaning machine, a route comprising the recorded transport path and the recorded cleaning path, and defining the cleaning operation. The robotic floor cleaning machine executes the defined route and the cleaning operation.

Abstract: A method of controlling a robotic floor cleaning machine includes driving, by an operator, the robotic floor cleaning machine along a transport path and a cleaning path. The transport path defines a path for transport of the robotic floor cleaning machine without active cleaning and the cleaning path defines a path for a cleaning operation. The method further includes recording the transport path and the cleaning path driven by the operator; defining, in a controller of the robotic floor cleaning machine, a route comprising the recorded transport path and the recorded cleaning path, and defining the cleaning operation. The robotic floor cleaning machine executes the defined route and the cleaning operation.

Abstract: Gravity assisted reservoir drainage systems and methods, which improve preexisting reservoir drainage systems and artificial lift methods using the interwell hydraulic communication that exists between closely spaced horizontal wells in certain fully developed leases completed with large multi-stage hydraulic fracture treatments in batch fashion.

Abstract: A generator set system includes an engine and an alternator. Control panels and switchboards for operating the generator set system are integrated into a frame/enclosure that is positioned around/above the alternator. The panels and switchboards are positioned on the sides of the enclosure to allow user access.

Abstract: Various embodiments that pertain to device software is described. A decision can be made by a device on if the device should download an update for device software, such as a software patch. When the device decides that it should download the update, the device can download the appropriate update. In one example, the update can be downloaded by way of a patch portal that communicates with a patch database. The device can request the patch for the software and in response the device can be provided access to the patch by way of the patch portal.

Abstract: Various embodiments that pertain to device software is described. A decision can be made by a device on if the device should download an update for device software, such as a software patch. When the device decides that it should download the update, the device can download the appropriate update. In one example, the update can be downloaded by way of a patch portal that communicates with a patch database. The device can request the patch for the software and in response the device can be provided access to the patch by way of the patch portal.

Abstract: A system includes a view screen with polarized output. A window capable of blocking the polarized output at least in part cloaks the view screen to frustrate viewing of the view screen through the window. In some cases, the window comprises an array of panels capable of blocking multiple polarizations. The array may disrupt multiple different polarized view screen outputs while maintaining transparency to unpolarized light. In some cases, the window capable of blocking polarized output may be paired with view screen cover that converts view screen output in an unblocked polarization to one of the one or more polarizations blocked by the window.