Abstract: A motion analytics system includes a footwear device having one or more sensors configured to detect motion of a user, and an external computing device. The external computing device includes a processor configured to receive motion data generated by the sensors and a non-transitory processor-readable memory coupled to the processor. The memory includes machine-readable instructions stored thereon that, when executed by the processor, causes the external computing device to perform a data analytics method. The data analytics method includes organizing the received data and filtering at least a portion of the organized data through a frequency-based signal processing filter to remove background noise and interference therefrom. The data analytics method further includes determining analytical data associated with one or more foot factors based on the filtered data. The data analytics method further includes categorizing the determined analytical data to provide context and insight to the user.

Abstract: LDL receptor-related proteins 1 and 2 (LRP-1 and LRP-2) and interaction between lactoferrin and LRP-1, LRP-2, or p42/44 MAP kinase in diagnosis and treatment of disorders such as bone or cartilage disorders. Also disclosed are methods of screening for related therapeutic compounds.