Abstract: A dynamic training system provides elevated load and energy demand on a rider of a moving bicycle out on the road or track. Resistance to movement of the bicycle is provided by a resistance unit which may include an eddy current brake. A processor may generate a control signal that adjusts the resistance to replicate the effort of riding a predetermined course or training protocol. Multiple riders at different times or locations can compete on a common virtual course. A stronger rider can be restrained by a heavier imposed load to keep pace together with a weaker rider, without compromising total power expenditure to keep the riders together.

Abstract: A neurovascular occlusion device for occluding a vessel and a delivery system for delivering the occlusion device. The occlusion device can include a self-expandable support structure defining a concave occlusive component and an anchoring component separated by a neck component. The occlusive component can carry a functionally occlusive membrane configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is expanded in the vessel.

Abstract: Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

Abstract: A vascular occlusion device having an expandable frame that carries a membrane. The membrane can include a tubular portion configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

Abstract: An enhanced flexibility catheter shaft having an elongate flexible body with a proximal end, a distal end, and at least one lumen extending therethrough.

Abstract: A dynamic training system provides elevated load and energy demand on a rider of a moving bicycle out on the road or track. Resistance to movement of the bicycle is provided by a resistance unit which may include an eddy current brake. A processor may generate a control signal that adjusts the resistance to replicate the effort of riding a predetermined course or training protocol. Multiple riders at different times or locations can compete on a common virtual course. A stronger rider can be restrained by a heavier imposed load to keep pace together with a weaker rider, without compromising total power expenditure to keep the riders together.

Abstract: An enhanced flexibility catheter shaft having an elongate flexible body with a proximal end, a distal end, and at least one lumen extending therethrough. A distal, flexible section on the body has a ribbed or corrugated tubular membrane having at least a first reinforcement structure, such as a first helical support, on a radially exterior or interior surface of the tubular membrane and optionally a second reinforcement structure, such as a second helical support, on the other of the radially interior or exterior surface of the tubular membrane.

Abstract: A dynamic training system provides elevated load and energy demand on a rider of a moving bicycle out on the road or track. Resistance to movement of the bicycle is provided by a resistance unit which may include an eddy current brake. A processor may generate a control signal that adjusts the resistance to replicate the effort of riding a predetermined course or training protocol. Multiple riders at different times or locations can compete on a common virtual course. A stronger rider can be restrained by a heavier imposed load to keep pace together with a weaker rider, without compromising total power expenditure to keep the riders together.

Abstract: The system includes an air flow generator configured to deliver an air flow at a positive therapeutic pressure during the treatment, and an expiratory valve with an open pressure connected to the air flow generator. The open pressure is dependent on the therapeutic pressure from the air flow generator. The expiratory valve further exerts a back pressure upon each exhalation from the patient sufficient to create a pneumatic splint in the patient's respiratory tract. The exhalation from the patient has a first half followed by a second half, and the back pressure is varied such that during the start of the first half, the back pressure is between 0 and 50% of a peak back pressure, and increases to a peak back pressure in the second half.

Abstract: Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

Abstract: A dynamic training system provides elevated load and energy demand on a rider of a moving bicycle out on the road or track. Resistance to movement of the bicycle is provided by a resistance unit which may include an eddy current brake. A processor may generate a control signal that adjusts the resistance to replicate the effort of riding a predetermined course or training protocol. Multiple riders at different times or locations can compete on a common virtual course. A stronger rider can be restrained by a heavier imposed load to keep pace together with a weaker rider, without compromising total power expenditure to keep the riders together.

Abstract: Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

Abstract: The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

Abstract: A neurovascular occlusion device for occluding a vessel and a delivery system for delivering the occlusion device. The occlusion device can include a self-expandable support structure defining a concave occlusive component and an anchoring component separated by a neck component. The occlusive component can carry a functionally occlusive membrane configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is expanded in the vessel.

Abstract: A system for treating a patient suffering from obstructive sleep apnea or snoring is diclsoed. The system includes an air flow generator configured to deliver an air flow at a positive therapeutic pressure during the treatment, and an expiratory valve with an open pressure connected air flow generator. The open pressure is dependent on the therapeutic pressure from the air flow generator. The expiratory valve further exerts a back pressure upon each exhalation from the patient sufficient to create a pneumatic splint in the patient's respiratory tract. The exhalation from the patient has a first half followed by a second half and the back pressure is varied such that during the start of the first half the back pressure is between 0 and 50% of a peak back pressure and increases to a peak back pressure in the second half.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.

Abstract: Stent delivery systems and associated methods for delivering stents are disclosed herein. In several embodiments, a handle assembly for delivering a stent from a tubular enclosure can include a first lead screw having a first lead thread of a first pitch and first handedness, a second lead screw having a second lead thread of a second pitch and second handedness different from the first handedness, and a housing defining threads of the first and second pitches. The first lead screw can be in mechanical communication with the tubular enclosure, and the second lead screw can be in mechanical communication with the stent. Upon rotation of a portion of the housing, the housing threads can engage the lead screws so as to induce simultaneous translations of the lead screws in opposite directions. The simultaneous translations are configured to deploy the stent from the tubular enclosure.

Abstract: A vascular occlusion device having an expandable frame that carries a membrane. The membrane can include a tubular portion configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.