Patents by Inventor Andrew Halpert

Andrew Halpert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12290380
    Abstract: A method to treat patients suffering from fluid overload including: administrating a diuretic to the patient to increase urine output of the patient; monitoring intravascular volume of the patient; and maintaining the patient in a condition in which the intravascular volume is below a baseline intravascular volume and above a hemodynamic level by adjusting the administered diuretic.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: May 6, 2025
    Assignee: Reprieve Cardiovascular, Inc.
    Inventors: Howard Levin, Andrew Halpert, Mark Gelfand
  • Publication number: 20250082933
    Abstract: A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath.
    Type: Application
    Filed: November 21, 2024
    Publication date: March 13, 2025
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert, Antonios Panteleon
  • Patent number: 12239819
    Abstract: A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: March 4, 2025
    Assignee: Reprieve Cardiovascular, Inc.
    Inventors: Howard R. Levin, Andrew Halpert, Zoar Engelman, Mark Gelfand
  • Patent number: 12064541
    Abstract: A method to protect kidneys of a patient undergoing cardiac surgery patient including: administrating a diuretic to the patient to increase urine output of the patient during cardiac surgery, wherein the diuretic is administered during the cardiac surgery; anesthetizing the patient with a general anesthetic during the cardiac surgery; infusing an intravenous liquid into the patient during the cardiac surgery; monitoring a rate or amount of urine output of the patient during the cardiac surgery, and automatically adjusting a rate or amount of the intravenous liquid infused into the patient to achieve or exceed a target urine output during the cardiac surgery.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: August 20, 2024
    Assignee: CARDIORENAL SYSTEMS, INC.
    Inventors: Andrew Halpert, Per Ulrich
  • Publication number: 20240260874
    Abstract: Embodiments of the present technology can manage a patient's fluid removal based on one or more of the patient's urine output, urine conductivity, urine sodium concentration, and/or urine oxygen content. For example, in some embodiments the patient's urine sodium concentration (and/or an indication thereof including, e.g., the patient's urine conductivity) can be compared to one or more urine sodium concentration thresholds (e.g., a high urine sodium concentration threshold and/or a low urine sodium concentration threshold) to determine one or more adjustments to the patient's therapy such as, e.g., a diuretic dosage rate, a hydration fluid infusion rate, a hydration fluid matching percentage, etc. Additionally or alternatively, the patient's urine oxygen content can be compared to one or more urine oxygen content thresholds (e.g., a high urine oxygen content threshold and/or a low urine oxygen content threshold) to determine one or more adjustments to the patient's therapy.
    Type: Application
    Filed: February 6, 2024
    Publication date: August 8, 2024
    Inventors: Andrew Halpert, Eric Conley, Jeffrey Testani
  • Publication number: 20240197244
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, and increasing the dosage rate of the diuretic from the initial dosage rate to additional dosage rates higher than the initial dosage rate over a period of time. In some embodiments, the additional dosage rates include a first dosage rate higher than the initial dosage rate, a second dosage rate higher than the first dosage rate, and a third dosage rate higher than the second dosage rate.
    Type: Application
    Filed: March 4, 2024
    Publication date: June 20, 2024
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Patent number: 11950925
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Grant
    Filed: April 5, 2023
    Date of Patent: April 9, 2024
    Assignee: REPRIEVE CARDIOVASCULAR, INC.
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Publication number: 20230347146
    Abstract: A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath.
    Type: Application
    Filed: July 11, 2023
    Publication date: November 2, 2023
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert, Antonios Panteleon
  • Publication number: 20230240600
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Application
    Filed: April 5, 2023
    Publication date: August 3, 2023
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Patent number: 11627912
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: April 18, 2023
    Assignee: Reprieve Cardiovascular, Inc.
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Publication number: 20230010793
    Abstract: The present technology includes devices, systems, and method for managing a patient's urine output. In some embodiments, an exemplary method includes receiving an estimated amount of excess fluid for the patient; obtaining a urine output rate of the patient; obtaining a diuretic dosage rate of the patient; obtaining (i) a first input corresponding to a percentage of an actual amount of net fluid loss relative to the estimated amount of excess fluid, and/or (ii) a second input corresponding to an estimated amount of fluid remaining; and based on the first input and/or the second input, providing an output associated with adjusting the fluid therapy. Providing the output can include providing an indication with instructions for increasing the patient's urine output by administering an additional diuretic and/or increasing infusion of hydration fluid to the patient.
    Type: Application
    Filed: July 12, 2022
    Publication date: January 12, 2023
    Inventors: Jeffrey Testani, Andrew Halpert, Kenneth John Luppi, Antony Jonathan Fields, Mark Richard Pacyna, Arslan Mazhar Malik
  • Publication number: 20220313158
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Application
    Filed: June 13, 2022
    Publication date: October 6, 2022
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Publication number: 20220218989
    Abstract: A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 14, 2022
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert, Antonis Panteleon
  • Patent number: 11357446
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: June 14, 2022
    Assignee: Reprieve Cardiovascular, Inc.
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Publication number: 20220176119
    Abstract: An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic nerve through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
    Type: Application
    Filed: March 1, 2022
    Publication date: June 9, 2022
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert
  • Patent number: 11305114
    Abstract: A system for treating disordered breathing of a human being includes an implantable transvenous stimulation lead having at least one stimulation electrode and a sensor configured to detect activity level of the human being. The system includes an energy source, a pulse generator and circuitry, the circuitry operative to receive a signal indicative of the activity level of the human being from the sensor, wherein the circuitry is configured to cause the energy source and the pulse generator to deliver spaced apart stimulation signals to the at least one stimulation electrode while the activity level of the human being is sufficiently low to be indicative of sleep. Spaced apart stimulation pulses from the electrode are configured to extend a duration of a time of at least one breath being defined as the time from an onset of inhalation to the onset of inhalation of a successive breath.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: April 19, 2022
    Assignee: ZOLL RESPICARDIA, INC.
    Inventors: Mark Gelfand, Howard Levin, Andrew Halpert, Antonis Panteleon
  • Patent number: 11305119
    Abstract: An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: April 19, 2022
    Assignee: ZOLL RESPICARDIA, INC.
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert
  • Publication number: 20210236727
    Abstract: A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.
    Type: Application
    Filed: May 16, 2019
    Publication date: August 5, 2021
    Inventors: Howard R. Levin, Andrew Halpert, Zoar Engelman, Mark Gelfand
  • Publication number: 20210169408
    Abstract: Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Inventors: Howard R. Levin, Jim Dillon, Andrew Halpert, Jeffrey Testani
  • Publication number: 20210113754
    Abstract: A method to protect kidneys of a patient undergoing cardiac surgery patient including: administrating a diuretic to the patient to increase urine output of the patient during cardiac surgery, wherein the diuretic is administered during the cardiac surgery; anesthetizing the patient with a general anesthetic during the cardiac surgery; infusing an intravenous liquid into the patient during the cardiac surgery; monitoring a rate or amount of urine output of the patient during the cardiac surgery, and automatically adjusting a rate or amount of the intravenous liquid infused into the patient to achieve or exceed a target urine output during the cardiac surgery.
    Type: Application
    Filed: December 30, 2020
    Publication date: April 22, 2021
    Inventors: Andrew HALPERT, Per Ulrich