Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: A transaction product assembly includes a perimeter frame defining a footprint, a plurality of parts maintained within the footprint of the perimeter frame, a transaction card, and a plurality of sprues. The transaction card includes a machine-readable account identifier linking the transaction card to an account or record, wherein the transaction card is maintained within the footprint of the perimeter frame. The plurality of sprues extend between the perimeter frame, the plurality of parts, and the transaction card to hold perimeter frame, the plurality of parts, and the transaction card together as a single piece. Areas within the footprint of the perimeter frame other than the plurality of parts, the transaction card, and the plurality of sprues remain substantially open and free of material.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: Apparatus, method, and manufacture, illustratively the aggregation apparatus connects to a sites on the Internet, authenticates itself with the sites, and facilitates at least one of: retrieving user-selected information from the sites, parsing the user-selected information from the sites to produce an aggregation, and rendering at least some of the aggregation as the output; retrieving information from the sites, parsing the information from the sites, and user-selectedly filtering the parsed information in producing an aggregation of the parsed information in producing an aggregation, and rendering at least some of the aggregation as the output; and retrieving information from the sites, parsing the information from the sites, producing an aggregation of the parsed information so as to produce an aggregation of the parsed information, and user-selectedly rendering the aggregation as the output. The rendering can include supplying content from one of the sites to another of the sites.

Abstract: A computerized aggregation system including a computer, a display controlled by the computer, and networking hardware connecting the computer to a network, the computer programmed so that the aggregation apparatus: connects to at least one Internet-connected service; and authenticates itself with each said Internet-connected service; and retrieves input from said Internet-connected service; and connects to at least one appliance computer; and then authenticates itself with each said appliance computer; and retrieves input from each said appliance computer; and parses the input from each said Internet-connected service and parses the input from each said appliance computer so as to produce an aggregation of the parsed input; and renders the aggregation as output.

Abstract: An aggregation apparatus including: a computer, an output device, a display controlled by the computer, and networking hardware connecting the computer to a network, the computer programmed so that the aggregation apparatus: communicates with at least one computer via the Internet to obtain peer-to-peer information corresponding to real time data shared by at least one other computer; processes the peer-to-peer information to produce an aggregation; and then renders the aggregation as output; and then presents at least some of the aggregation and at least one of at least some of the information in a customizable user interface, at least some of the aggregation in association with an automatically generated score that represents a level of communication activity, and at least some of the information in a user interface which includes an automatically generated list of contacts and their associated recent activity.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product.

Abstract: A transaction product assembly includes a perimeter frame defining a footprint, a plurality of parts maintained within the footprint of the perimeter frame, a transaction card, and a plurality of sprues. The transaction card includes a machine-readable account identifier linking the transaction card to an account or record, wherein the transaction card is maintained within the footprint of the perimeter frame. The plurality of sprues extend between the perimeter frame, the plurality of parts, and the transaction card to hold perimeter frame, the plurality of parts, and the transaction card together as a single piece. Areas within the footprint of the perimeter frame other than the plurality of parts, the transaction card, and the plurality of sprues remain substantially open and free of material.

Abstract: An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition comprises a multiparticulate modified release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules as the primary package. The oral dosage units are supplied as part of a kit, which also includes a package insert all sold as a commercially marketed product. The primary package and package insert are contained in an optional secondary package and the package insert does not contain a warning, a dosing instruction, or a dosing table specifically directed to patients suffering from mild, moderate or severe hepatic impairment.

Abstract: A computerized aggregation system including a computer, a display controlled by the computer, and networking hardware connecting the computer to a network, the computer programmed so that the aggregation apparatus: connects to at least one Internet-connected service; and authenticates itself with each said Internet-connected service; and retrieves input from said Internet-connected service; and connects to at least one appliance computer; and then authenticates itself with each said appliance computer; and retrieves input from each said appliance computer; and parses the input from each said Internet-connected service and parses the input from each said appliance computer so as to produce an aggregation of the parsed input; and renders the aggregation as output.