Abstract: Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof: Formula (IVA), wherein “RIa”, “RIb”, “RIc”, “RId”, “RIe”, are defined herein above, which compounds are believed suitable for use in positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7 nAChR) receptors, for example, those found in the cerebral cortex and the hippocampus. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Alzheimer's disease (AD), schizophrenia, and Parkinson's disease (PD), or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: The invention comprises systems and devices for calculating and displaying real-time race information to a racer during a race. A portable race device may be worn by a racer. During the race, while within range of a race gate transmission, the race device receives gate crossing times for other race participants, and may calculate and display the current positions and times for a selected race group, and the pace needed for the racer to win, and also may display the projected finish positions and times for a selected race group, and the pace needed for the racer to win.

Abstract: The present invention relates to chemical compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7 nAChR).

Abstract: A method of forming tailored cast blanks including determining at least one of a thickness pattern or profile pattern for a blank, generating a layout for a series of blanks having the determined thickness or profile pattern and casting a strip in accordance with the layout, including varying the caster width during casting of the strip.

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: The present invention relates to chemical compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7 nAChR).

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of ?7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.

Abstract: The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of ?7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.

Abstract: The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of ?7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.

Abstract: A contact management system is described having a first database containing proprietary information and a second database containing public information. Where appropriate, the publicly available information is displayed with the proprietary information to give the user more information about a contact. The multiple relationships provided by the public database allow the user to use both the proprietary and public data to find a relationship with a potential client.

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract: The invention comprises systems and devices for calculating and displaying real-time race information to a racer during a race. A portable race device may be worn by a racer. During the race, while within range of a race gate transmission, the race device receives gate crossing times for other race participants, and may calculate and display the current positions and times for a selected race group, and the pace needed for the racer to win, and also may display the projected finish positions and times for a selected race group, and the pace needed for the racer to win.

Abstract: The present invention relates to compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (?7nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of ?7nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also inflammatory diseases.

Abstract: PSF coding has become well known in recent years. Although it enables significant increases in the depth of field, defocus introduces artifacts in images that are a major detraction from the final image quality. A method is described that enables the deduction or defocus and consequently the removal of these artifacts. The principle of the disclosed techniques involves iteratively adjusting the restoration algorithm according to a chosen image or artifact metric and choosing the defocus parameter that yields the image the lowest level of artifact.

Abstract: A pulse width modulation circuit may generate an adjustable output signal that periodically transitions between a first and a second state with an adjustable duty cycle. A first pulse generator circuit may be configured to generate a first pulse signal that periodically transitions at an adjustable delay with respect to a periodic reference signal. A second pulse generator circuit may be configured to generate a second pulse signal that periodically transitions at an adjustable delay with respect to the periodic reference signal. A logic circuit may be configured to generate the adjustable output signal based on both the first and the second pulse signals.

Abstract: A zoom lens system includes a variator lens group, a compensator lens group and a third lens group. The compensator lens group is arranged to only partially compensate for movement of the variator group. In order to provide further compensation for the zoom lens, an image enhancer implement wavefront coding and artifact reduction techniques. The compensator group may be fixed or alternatively, its movement relative to the variator may be effected by a simple cam mechanism.

Abstract: PSF coding has become well known in recent years. Although it enables significant increases in the depth of field, defocus introduces artifacts in images that are a major detraction from the final image quality. A method is described that enables the deduction or defocus and consequently the removal of these artifacts. The principle of the disclosed techniques involves iteratively adjusting the restoration algorithm according to a chosen image metric and choosing the defocus parameter that yields the image the lowest level of artifact.

Abstract: A pulse width modulation circuit may generate an adjustable output signal that periodically transitions between a first and a second state with an adjustable duty cycle. A first pulse generator circuit may be configured to generate a first pulse signal that periodically transitions at an adjustable delay with respect to a periodic reference signal. A second pulse generator circuit may be configured to generate a second pulse signal that periodically transitions at an adjustable delay with respect to the periodic reference signal. A logic circuit may be configured to generate the adjustable output signal based on both the first and the second pulse signals.