Abstract: Systems and methods for in situ laser lysis for analysis of biological tissue (live, fixed, frozen or otherwise preserved) at single cell resolution in 3D. For example, a system and method for lysing individual cells in situ, including the steps of capturing a tissue sample comprising a cellular content, subjecting the tissue sample to a stream of continuous fluid flow, lysing a selected area of the tissue sample with a laser, thereby releasing at least a portion of the cellular content from the tissue sample, recovering at least one target molecule from the cellular content in the stream, and processing at least one target molecule is provided. The system collects cellular contents, performs highly multiplexed (RT-qPCR or RNA-seq), and sequentially (cell-by-cell) reconstructs a 3D spatial map of mRNA expression of the tissue with a large number of genes. A 3D spatial map of the DNA, RNA, and/or proteins can be generated for each cell in the tissue.

Abstract: The present invention provides a system and method for lysing individual cells in situ, including the steps of capturing a tissue sample comprising a cellular content, subjecting the tissue sample to a stream of continuous fluid flow, lysing a selected area of the tissue sample with a laser, thereby releasing at least a portion of the cellular content from the tissue sample, recovering at least one target molecule from the cellular content in the stream, and processing the at least one target molecule.

Abstract: A method for adaptive display of internet advertisements to look-alike users using a desired user profile dataset as a seed to machine learning modules. Upon availability of a desired user profile, that user profile is mapped other look-alike users (from a larger database of users). The method proceeds to normalize the desired user profile object, proceeds to normalize known user profile objects, then seeding a machine-learning training model with the normalized desired user profile object. A scoring engine uses the normalized user profiles for matching based on extracted features (i.e. extracted from the normalized user profile objects). Once look-alike users have been identified, the internet display system may serve advertisements to the look-alike users, and analyze look-alike users' behaviors for storing the predicted similar user profile objects into the desired user profile object dataset, thus adapting to changing user behavior.

Abstract: A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

Abstract: A non-contact system for sorting monodisperse water-in-oil emulsion droplets in a microfluidic device based on the droplet's contents and their interaction with an applied electromagnetic field or by identification and sorting.

Abstract: A method for adaptive display of internet advertisements to look-alike users using a desired user profile dataset as a seed to machine learning modules. Upon availability of a desired user profile, that user profile is mapped other look-alike users (from a larger database of users). The method proceeds to normalize the desired user profile object, proceeds to normalize known user profile objects, then seeding a machine-learning training model with the normalized desired user profile object. A scoring engine uses the normalized user profiles for matching based on extracted features (i.e. extracted from the normalized user profile objects). Once look-alike users have been identified, the internet display system may serve advertisements to the look-alike users, and analyze look-alike users' behaviors for storing the predicted similar user profile objects into the desired user profile object dataset, thus adapting to changing user behavior.

Abstract: Improved lubricant and surface conditioner forming composition containing oxa acids and their methyl esters corresponding to general formula (I): H3C—(CH2)n—CH?CH—(CH2)m—O—(CH2CH2O)x—CH2—C(?O)—OR??(I) where each of m, n and x, which may be the same or different, is a positive integer and R represents H or CH3, when dissolved and/or dispersed in water is effective in reducing COF values on substrates that have been contacted with such a lubricant and surface conditioner forming composition and subsequently dried, even when the substrates have been conversion coated and rinsed before any contact with the lubricant and surface conditioner forming composition. Materials according to general formula (I) may be used together with other surfactants, including some constituents of previously known lubricant and surface conditioner forming compositions to provide improvements in COF, waterbreak performance, water drainage and resistance to dry-off of the conditioner.

Abstract: A messaging server (112) provides a message store (116) for storing messages in a relational manner. A set of related messages, such as an email string between two or more people, is represented as a message container (200) having relational references to one or more submessages (210, 212, 214). The messaging server (112) processes non-relational messages sent by the server by inserting (516) tags that uniquely identify components within the message. The messaging server (112) also processes tagged or untagged non-relational messages received by the server to create (616, 618) relational counterparts in the message store (116). Relational searches can be executed on the messages in the message store (116) to perform audits or forensic analyses of the messages.

Abstract: A messaging system treats a set of related messages, such as an email string between two or more people, as a message container (200) having relational references to one or more submessages (210, 212, 214). A messaging server (112) stores the messages and submessages as discrete message components within a message database (416). The messaging server (112) generates (714) tamper-detection data, such as hashes, for the message components and stores the data in an audit information database (418). The messaging server (112) authenticates (627) a message component by generating new tamper-detection data for the component, and comparing the new data with the stored data. In addition, the messaging server (112) can distribute the tamper-detection information to other entities, such as messaging clients (116), by signing the data using a digital signature. The messaging system thus allows distributed entities to verify the authenticity of messages and components sent via the system.

Abstract: A messaging system enforces compliance policies for the electronic messages. The messaging system treats a set of related messages, such as an email string between two or more people, as a message container (200) having relational references to one or more submessages (210, 212, 214). A messaging server (112) stores the messages and submessages as discrete message components within a message database (416). In addition, the messaging server (112) stores one or more compliance policies. A compliance policy describes the set of rules that apply to message components during their lifecycles and is defined in terms of a population structure, a set of rules, and a set of jobcodes. When an action occurs that involves a piece of content, the messaging system identifies the relevant compliance policy in the governance policy database (424) and applies any rules that are applicable given the population structure and jobcode.

Abstract: A messaging server (116) supports a relational message transport protocol (RMTP). The RMTP server (116) discovers whether other messaging servers on a network (112) support the RMTP. In pre-discovery, the RMTP server (116) uses (320) simple mail transport protocol (SMTP) command lines to discover whether another messaging server supports RMTP. In post-discovery, the RMTP server (116) encodes the message with data that are recognized by a RMTP server and delivers (324) the data using a conventional protocol such as SMTP. A RMTP server (116) that receives the encoded message initiates (312) a RMTP connection with the sending server. The RMTP server (116) maintains a database of discovered servers (216) and provides a directory interface (218) that other RMTP servers can use to access the database.

Abstract: A messaging server (112, 612) stores messages exchanged using a messaging system. Messages, and components of messages, are cached (120, 618) closer to the messaging clients (116, 616). Messaging client (116, 616) requests for messages are served from the cache (120, 618) rather than from the messaging server (112, 612). The messages can be secured using security information (920) stored at the messaging server (112, 612). The messaging server (112, 612) sends the security information directly to the messaging clients (116, 616).

Abstract: This invention provides a vision system that increases the field of view of an electronic binocular system without degrading image quality or requiring extremely large format sensors or displays. The vision system comprises an imaging device coupled with a viewing device. The imaging device comprises a compression lens and an image sensor. The viewing device comprises an image display and a decompression lens. The compression lens matches the optical distortion to the human visual acuity curve for field positions greater than an angle .theta.. Below angle .theta. there is substantially no distortion. The optimum angle .theta. depends on the application. For an average individual viewing a landscape the angle .theta. is about 10.degree.. For different viewing objects, the optimum angle .theta. varies from about 5.degree. to about 15.degree.. The image sensor can be infrared sensitive for infrared viewing.