Abstract: A vacuum therapy device for treatment of a defect internal of a human or animal body, the device comprising: a suction tube extending from: (i) a proximal portion for coupling to a source of negative pressure outside the body, to (ii) a distal portion for providing suction proximal to the defect when inserted into the body; a porous medium coupled to the distal portion of the suction tube to provide suction to the defect when inserted into the body for treatment thereof; and a constraining sleeve for selective compression of the porous medium, the constraining sleeve having a proximal end and a distal end, wherein the constraining sleeve is movable relative to the porous medium between: an insertion position in which the proximal and distal ends of the sleeve are arranged at the distal portion of the suction tube so that the sleeve at least partially surrounds the porous medium to retain the porous medium in a compressed state during insertion into the body; and a treatment position in which the porous medium

Abstract: A multi-factor authentication method and system is provided such that a push notification during an authentication process is only received if a mobile device and user are authenticated prior to receiving the push notification. Either the mobile device itself or a second device sending the push notification may be programmed to either reject or not forward the authentication request. Additionally, using the method of the present invention, enhanced security is provided by requiring the location of the mobile device and the second device to be approximately in the same geographical location.

Abstract: A multi-factor authentication method and system is provided such that a push notification during an authentication process is only received if a mobile device and user are authenticated prior to receiving the push notification. Either the mobile device itself or a second device sending the push notification may be programmed to either reject or not forward the authentication request. Additionally, using the method of the present invention, enhanced security is provided by requiring the location of the mobile device and the second device to be approximately in the same geographical location.

Abstract: A method of making a media usable for instance in hydroponics. The method comprising mixing together three components, granulating the mixture and firing the granules formed, the first component is silica sand, the second component is mica granite sand, and the third component is a glass powder, with the firing taking place at a temperature such that the third component melts during firing.

Abstract: A multi-factor authentication method and system is provided such that a push notification during an authentication process is only received if a mobile device and user are authenticated prior to receiving the push notification. Either the mobile device itself or a second device sending the push notification may be programmed to either reject or not forward the authentication request. Additionally, using the method of the present invention, enhanced security is provided by requiring the location of the mobile device and the second device to be approximately in the same geographical location.

Abstract: The disclosure relates to an adjuvant polypeptide effective at enhancing the immune response to an antigen crosslinked to the adjuvant polypeptide.

Abstract: The disclosure relates to a vaccine including at least one adjuvant useful in the prevention and treatment of blood cancers, for example lymphoma, leukaemia or myeloma.

Abstract: A method, system, and computer program product provides the capability to compare data object definitions in a database in a less costly and less time-consuming manner than previous techniques. A method of comparing multiple versions of data item definitions in a database comprises generating a first version of comparison information relating to a plurality of data item definitions in the database by comparing information relating to data item definitions obtained from a first source and information relating to data item definitions obtained from a second source and generating a second version of comparison information relating to a plurality of data item definitions in the database by comparing information relating to data item definitions obtained from a first source and information relating to data item definitions obtained from a second source to the first version of comparison information.

Abstract: We describe a conjugate comprising an antibody and antigen wherein said conjugate has low antibody valency and including methods to prepare said conjugate.

Abstract: The invention relates to a set of novel immunological adjuvants based upon so called “polyladder” proteins of nematode worms. These proteins are typified by repeating units separated by a protease cleavage motif of RX(K/R)R or RXFR where R is ariginine, X is any amino acid, K is lysine and F is phenylalanine. These motifs are preceded by a cysteine residue at around 7, 8 or 9 residues upstream. Polyladder proteins or fragments of polyladder proteins may be used as immunological adjuvants either mixed with, or conjugated to a vaccine antigen, and will strongly enhance the immune response against the antigen. Conjugation may take the form of a genetic fusion between adjuvant and antigen. Antigens may be derived from pathogens, or may be tumour antigens, autoantigens, or antigens of other kinds. Vaccines may be used for prophylaxis or therapy.

Abstract: We describe a conjugate comprising an anti-CD40 or anti-CD28 antibody and antigen wherein said conjugate has low antibody valency and including methods to prepare said conjugate.

Abstract: A method to protect a host animal from flea infestation by treating that animal with a composition that includes a compound that reduces protease activity of fleas feeding from the treated animal, thereby reducing flea burden on the animal and in the environment of the animal. The present invention also relates to compositions including flea protease vaccines, anti-flea protease antibodies and/or protease inhibitors. Also included in the present invention are soluble flea midgut preparations, flea protease proteins, nucleic acid molecules encoding such proteins and antibodies that selectively bind to such proteins. The present invention also includes methods to obtain and use such preparations, proteins, nucleic acid molecules, antibodies and protease inhibitors to protect an animal from flea infestation.