Abstract: A device for estimating a mechanical property of a sample is disclosed herein. The device may include a chamber configured to hold the sample; a transmitter configured to transmit a plurality of waveforms, including at least one forcing waveform; and a transducer assembly operatively connected to the transmitter and configured to transform the transmit waveforms into ultrasound waveforms. The transducer assembly can also transmit and receive ultrasound waveforms into and out of the chamber, as well as transform at least two received ultrasound waveforms into received electrical waveforms.

Abstract: A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.

Abstract: Systems and methods are provided for enhanced processing of time series data via parallelization of instructions. An example method includes receiving a query indicating time series datasets and operations to be performed on the time series datasets. Nodes associated with the query are identified, with each node associated with a time series dataset. Nodes associated with operations to be performed are generated. The nodes are assembled into query tree, with parent nodes of the query tree indicating operations that are to be applied to children nodes. Instructions for processing the query tree are generated. At least a subset of the instructions is provided to one or more compute systems for processing in parallel. Results are received, and presented in a user interface.

Abstract: Aspects of the present disclosure are directed to a universal tracking module (UTM) capable of tracking six degrees of freedom of objects. In artificial reality environments, six degrees of freedom tracking refers to the ability to track an object moving and rotating freely in three-dimensional space along three axes of movement and rotation. Six degrees of freedom tracking provides high precision in tracking movement and rotation in 3D space, enabling more accurate and realistic representations of objects and interactions in virtual and augmented reality environments, thereby allowing for more realistic and immersive experiences. In examples, the UTM includes a plurality of light-emitting diodes such that an image of the UTM can be utilized to determine the position and orientation of the UTM and the object to which the UTM is attached.

Abstract: The present application relates to combination compositions comprising one or more hallucinogens, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and one or more fatty acids, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof. The present application also relates to intranasal pharmaceutical compositions comprising one or more hallucinogens, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof, and one or more fatty acids, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof. For example, the one or more hallucinogens is 5-methoxy-N,N-dimethyltryptamine or a pharmaceutically acceptable salt thereof and the one or more fatty acids is linoleic acid.

Abstract: The present application relates to 3-amino-indole derivatives of general Formula (I-B), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptors in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptors in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses and CNS disorders.

Abstract: The present application relates to 3-amino-indole derivatives of general Formula (I-A), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptors in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptors in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses and CNS disorders.

Abstract: A handheld controller configured to be held by a user's hand. The handheld controller comprising a main body, and a handle extending from the main body, wherein the handle has a palm side and a finger side. A control button is positioned on the main body or handle, and a detection sensor is on the handle. The detection sensor is positioned to detect the presence of the finger or palm of a user's hand engaging the handle. The detection sensor can be a capacitive touch sensor, a proximity sensor or other detection sensor operative to detect the touch or spatial presence of the user's hand or fingers.

Abstract: Systems and methods are provided for enhanced processing of time series data via parallelization of instructions. An example method includes receiving a query indicating time series datasets and operations to be performed on the time series datasets. Nodes associated with the query are identified, with each node associated with a time series dataset. Nodes associated with operations to be performed are generated. The nodes are assembled into query tree, with parent nodes of the query tree indicating operations that are to be applied to children nodes. Instructions for processing the query tree are generated. At least a subset of the instructions is provided to one or more compute systems for processing in parallel. Results are received, and presented in a user interface.

Abstract: A handheld controller configured to be held by a user's hand. The handheld controller comprising a main body, and a handle extending from the main body, wherein the handle has a palm side and a finger side. A control button is positioned on the main body or handle, and a detection sensor is on the handle. The detection sensor is positioned to detect the presence of the finger or palm of a user's hand engaging the handle. The detection sensor can be a capacitive touch sensor, a proximity sensor or other detection sensor operative to detect the touch or spatial presence of the user's hand or fingers.

Abstract: As disclosed herein, a system may comprise a handheld device in electronic communication with a controller. The handheld device may comprise a housing defining an internal cavity and an orifice providing access to the internal cavity. A trigger may comprise an external and an internal surface. The trigger may be oriented to cover the orifice. A transfer member may be oriented in the internal cavity and coupled to the internal surface of the trigger. A force sensor may be oriented in the internal cavity and may engage a distal end of the transfer member and the internal surface of the trigger. A transfer roller may be oriented in the internal cavity and coupled to the distal end of the transfer member. A cam may be oriented in the internal cavity and may engage the transfer member. A motor may be oriented in the internal cavity and coupled to the cam.

Abstract: Systems and methods are provided for enhanced processing of time series data via parallelization of instructions. An example method includes receiving a query indicating time series datasets and operations to be performed on the time series datasets. Nodes associated with the query are identified, with each node associated with a time series dataset. Nodes associated with operations to be performed are generated. The nodes are assembled into query tree, with parent nodes of the query tree indicating operations that are to be applied to children nodes. Instructions for processing the query tree are generated. At least a subset of the instructions is provided to one or more compute systems for processing in parallel. Results are received, and presented in a user interface.

Abstract: Disclosed herein are compositions and methods of treating neuropsychiatric and cognitive conditions with single, repeat and/or extended release 5-HT receptor agonist dosage forms.

Abstract: A hand-held controller includes a handle extending in a longitudinal direction. The handle is shaped and dimensioned to be grasped by a hand of a user. A ring is attached to an end of the handle and surrounds a thumb of the user when the handle is grasped by the hand of the user. The ring has an annular surface defining a plane that forms a predetermined angle with respect to the longitudinal direction. The ring also has a curved outer surface. A sensor is embedded within the ring or mounted on a side surface of the handle to detect whether the hand of the user grasping the handle is a right hand of the user or a left hand of the user.

Abstract: A hand-held controller includes a handle extending in a longitudinal direction. The handle is shaped and dimensioned to be grasped by a hand of a user. A ring is attached to an end of the handle and surrounds a thumb of the user when the handle is grasped by the hand of the user. The ring has an annular surface defining a plane that forms a predetermined angle with respect to the longitudinal direction. The ring also has a curved outer surface. A sensor is embedded within the ring or mounted on a side surface of the handle to detect whether the hand of the user grasping the handle is a right hand of the user or a left hand of the user.

Abstract: A computer-implemented method is provided to visualize data related to one or more assets utilizing an interactive geospatial map. The system may receive query criteria, indicating a geographic region of interest and/or timespan of interest, and may access a plurality of datasets including a first dataset comprising data items associated with default locations of assets and a second dataset comprising data items associated with transit events of assets, and wherein the plurality of datasets are associated with geographic locations and respective times. The system may query the plurality of datasets to determine, for assets associated with the one or more data items, expected geographic locations of the assets, and may generate user interface data configured for rendering an interactive user interface including an interactive geospatial map with indications of the expected geographic locations of the assets, and a plurality of interactive tables.

Abstract: A computer-implemented method is provided to visualize data related to one or more assets utilizing an interactive geospatial map. The system may receive query criteria, indicating a geographic region of interest and/or timespan of interest, and may access a plurality of datasets including a first dataset comprising data items associated with default locations of assets and a second dataset comprising data items associated with transit events of assets, and wherein the plurality of datasets are associated with geographic locations and respective times. The system may query the plurality of datasets to determine, for assets associated with the one or more data items, expected geographic locations of the assets, and may generate user interface data configured for rendering an interactive user interface including an interactive geospatial map with indications of the expected geographic locations of the assets, and a plurality of interactive tables.

Abstract: Systems and methods are provided for enhanced processing of time series data via parallelization of instructions. An example method includes receiving a query indicating time series datasets and operations to be performed on the time series datasets. Nodes associated with the query are identified, with each node associated with a time series dataset. Nodes associated with operations to be performed are generated. The nodes are assembled into query tree, with parent nodes of the query tree indicating operations that are to be applied to children nodes. Instructions for processing the query tree are generated. At least a subset of the instructions is provided to one or more compute systems for processing in parallel. Results are received, and presented in a user interface.

Abstract: Systems and methods are provided for enhanced processing of time series data via parallelization of instructions. An example method includes receiving a query indicating time series datasets and operations to be performed on the time series datasets. Nodes associated with the query are identified, with each node associated with a time series dataset. Nodes associated with operations to be performed are generated. The nodes are assembled into query tree, with parent nodes of the query tree indicating operations that are to be applied to children nodes. Instructions for processing the query tree are generated. At least a subset of the instructions is provided to one or more compute systems for processing in parallel. Results are received, and presented in a user interface.