Abstract: A safety razor has a blade unit with a housing and a razor blade, and an elongated handle having a uniform thickness and having a first end including an aperture extending into the thickness, and an opposed second end. The safety razor also has a connector to connect the blade unit to the handle. A body of the connector has a recess with an opening, and a user-operable latch including a protrusion extending into the recess. The first end of the handle is removably received in the recess and the protrusion is received in the aperture to secure the handle to the connector. The protrusion is releasable from the aperture by a user-applied force to a lever at an end of the latch opposite the protrusion end to release the first end of the handle from the recess.

Abstract: A shaving system has a razor cartridge with a blade unit and handle connection structure having a first magnetic element, and a handle having a magnet mounted to the handle and an ejector button having a second magnetic element, movable between a first position and a second position. When the razor cartridge is attached to the handle and the ejector button is in its first position, the second magnetic element of the ejector button is positioned between the magnet of the handle and the first magnetic element of the razor cartridge. When the ejector button is moved to its second position, magnetic attraction between the magnet and the first magnetic element is reduced and the razor cartridge is unattached from the handle. When a user releases the ejector button, magnetic attraction between the magnet and the second magnetic element returns the ejector button to its first position.

Abstract: Historical analysis of query patterns is used to discover relationships between data sets. These relationships are used to make optimal decisions about where to place data in a globally distributed environment in which locality of data is an important factor in providing good query performance. A mixed integer programming model is used to solve a constraint based system which balances the need to have data kept local with other data and the cost of replicating data across a low-bandwidth network.

Abstract: A shaving system has a razor cartridge with a blade unit and handle connection structure having a first magnetic element, and a handle having a magnet mounted to the handle and an ejector button having a second magnetic element, movable between a first position and a second position. When the razor cartridge is attached to the handle and the ejector button is in its first position, the second magnetic element of the ejector button is positioned between the magnet of the handle and the first magnetic element of the razor cartridge. When the ejector button is moved to its second position, magnetic attraction between the magnet and the first magnetic element is reduced and the razor cartridge is unattached from the handle. When a user releases the ejector button, magnetic attraction between the magnet and the second magnetic element returns the ejector button to its first position.

Abstract: Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

Abstract: Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

Abstract: The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor

Abstract: A safety razor is provided comprising a razor cartridge mounted on pivoting connecting structure of a handle. The razor cartridge has four or more razor blades. The pivot axis of the razor cartridge is rearward of the midpoint of the cartridge width and below a plane tangent to the guard and cap structures of the housing of the razor cartridge.

Abstract: The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.

Abstract: Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine.

Abstract: The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor

Abstract: A safety razor is provided comprising a razor cartridge mounted on pivoting connecting structure of a handle. The razor cartridge has four or more razor blades. The pivot axis of the razor cartridge is rearward of the midpoint of the cartridge width and below a plane tangent to the guard and cap structures of the housing of the razor cartridge.

Abstract: According to the present invention, a razor handle includes a connecting pod and a first handle portion. The connecting pod has a cartridge-connecting member, and a handle-connecting member. The first handle portion includes a pod-connecting member, and includes a first molded portion, a battery-powered device, and a second molded portion. The battery-powered device is at least partially encased between the first molded portion and the second molded portion. The handle-connecting member of the connecting pod is connected to the pod-connecting member of the first handle portion such that the connecting pod and the first handle portion are not detachable during normal use of the razor handle. The cartridge-connecting member of the connecting pod is operable to connect to a selectively detachable razor cartridge.

Abstract: A method for modifying the cyclic peptide ring system of Echinocandin-type compounds to produce new analogs having antifungal activity is provided. The inventive process comprises opening the cyclic peptide ring, cleaving the terminal ornithine unit, inserting at least one new amino acid or other synthetic unit and closing the ring to produce a new cyclic peptide ring structure. The process allows one to incorporate features such as water-solubility into the cyclic peptide ring nucleus, sites for further modification, increase or decrease the number of amino acid or peptide units within the ring nucleus, and increase or decrease the total number of members within the ring. The invention further provides novel Echinocandin type compounds and their use as antifungal or anti-parasitic agents.