Abstract: A package substrate is provided, in which dielectric layers are formed on a core board, and a wiring layer is embedded in at least one of the dielectric layers, so that the wiring layer has better copper adhesion to prevent delamination problems. A method of fabricating the package substrate is also provided.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing a program and method for displaying content feeds within a messaging system. The program and method provide for receiving, by a messaging application associated with a user, user input corresponding to a request for a first content feed, the first content feed comprising a first plurality of media content items provided by one or more friends of the user; providing for display of the first content feed; determining, by the messaging application, that display of the first content feed is complete; and providing, in response to determining that display of the first content feed is complete, for display of a second content feed, the second content feed comprising a second plurality of media content items provided by one or more content providers to which the user subscribes with respect to the messaging application.

Abstract: A pallet truck includes a drive frame on which a drive wheel support is pivotably supported, a load frame, which is liftable with respect to the drive frame in a lifting direction, and a hydraulic lift module, which interconnects the drive frame and the load frame. The hydraulic lift module includes a hydraulic lift cylinder, which includes a cylinder barrel and a piston rod, wherein the cylinder barrel includes a cap end at one end portion of the cylinder barrel and a rod end at the other end portion of the cylinder barrel, wherein the piston rod extends outwards from the cylinder barrel at the rod end of the cylinder barrel and wherein a free end of the piston rod is accommodated in the drive frame. In the lifting direction, the cap end of the cylinder barrel is arranged above the rod end of the cylinder barrel.

Abstract: A display may include an array of pixels such as light-emitting diode pixels. The pixels may include multiple circuitry decks that each include one or more circuit components such as transistors, capacitors, and/or resistors. The circuitry decks may be vertically stacked. Each circuitry deck may include a planarization layer formed from a siloxane material that conforms to underlying components and provides a planar upper surface. In this way, circuitry components may be vertically stacked to mitigate the size of each pixel footprint. The circuitry components may include capacitors that include both a high-k dielectric layer and a low-k dielectric layer. The display pixel may include a via with a width of less than 1 micron.

Abstract: Systems and methods for distribution, storage, transport, administration and/or disposal of one or more therapeutic or diagnostic agents are disclosed. A storage device configured to connect to a delivery system for delivering the therapeutic or diagnostic agent has a housing with a chamber, a vessel having an access port positioned within the chamber. The door is movable relative to the housing between a closed position and an open position. In the closed position, the door covers an opening in the housing to enclose the chamber, and, in the open position, the door reveals the opening for accessing the access port of the vessel. The door is moveable between the closed position and the open position in response to actuation by an access mechanism of the delivery system.

Abstract: Systems and methods are described herein to control brightness based on image content or other inputs to a display system. A dual-control system may integrate both slow control operations and fast control operations into a cohesive brightness management system. By using both shorter-term (e.g., fast control) and longer-term (e.g., slow control) brightness adjustment operations, the electronic device may quickly respond to high luminance and high brightness situations that may cause burn-in into the display, image artifacts, or other damage. Responding quickly to these high consumption situations may prevent damage or perceivable upset to an ongoing process, among other benefits.

Abstract: Systems and methods for object-based content recommendation are described. A camera feed comprising a plurality of image frames is caused to be displayed at a client device. An object is detected within an image frame from the camera feed, the object corresponding with an object category. Responsive to detecting the object, an icon associated with the object category is selected and displayed at a position upon the camera feed. The icon corresponds with a media collection related to the object category. An input is received selecting the icon. Responsive to the input, a presentation of media items from the media collection is displayed at the client device. By detecting real-world objects and surfacing relevant virtual icons that link to associated media, an augmented reality experience is provided allowing virtual content to be overlaid and anchored to objects in reality.

Abstract: A switching bridge for the DC-DC stage of a power converter, the switching bridge having one or more sets of upper and lower series-connected switches (S1, S2) connected across a DC bus and arranged to be switched to provide an output AC voltage, the switching bridge further comprising a voltage divider (C1) arranged to vary the output AC voltage level according to the switching state of the switches.

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.

Abstract: A coating device includes at least one applicator configured to coat a glue onto two opposite sides of an electrode sheet; at least one roller assembly configured to guide the electrode sheet past the at least one applicator; and at least one support bar arranged under the at least one applicator.

Abstract: The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1's RNase activity. In other embodiments, the compounds of the invention are useful to treat or prevent a cancer that involve activation of the ER stress response. The invention also relates, in certain aspects, to the discovery that secretory IgM (sIgM) can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) into different tumor models, such as but not limited to solid tumors (such as lung cancer) and tumors that have high levels of secreted IgM. In certain embodiments, sIgM produced by B cells or CLL cells can contribute to the accumulation of MDSCs in a tumor. In other embodiments, inhibition of the IRE1/XBP-1 pathway can ablate, minimize, or reduce MDSC levels in a tumor.

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.

Abstract: A phonograph record player including a speaker enclosure within the record player that is mechanically insulated from the phonograph components to reduce vibrations from the speakers to the phonograph components. One or more coupling mechanisms are used that absorb, reduce, and/or minimize vibrations generated by components coupled to a secondary housing, such as speakers, from being transmitted to a primary housing that includes a turntable.

Abstract: The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1's RNase activity. In other embodiments, the compounds of the invention are useful to treat or prevent a cancer that involve activation of the ER stress response. The invention also relates, in certain aspects, to the discovery that secretory IgM (sIgM) can orchestrate an immunosuppressive microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) into different tumor models, such as but not limited to solid tumors (such as but not limited to lung cancer) and tumors that have high levels of secreted IgM. In certain embodiments, sIgM produced by B cells or CLL cells can contribute to the accumulation of MDSCs in a tumor. In other embodiments, inhibition of the IRE1/XBP-1 pathway can ablate, minimize, or reduce MDSC levels in a tumor.

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model.

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model. In still further aspects, the disclosed subject matter relates to methods for treating oncological and inflammatory disorders in a patient. For example, disclosed herein are methods whereby an effective amount of a compound or composition disclosed herein is administered to a patient having an oncological disorder, for example B-cell chronic lymphocytic leukemia (CLL), and who is in need of treatment thereof. XBP-1 deficiency causes leukemic cells to acquire phenotypes that are disadvantageous for their survival, such as compromised BCR signaling capability and increased surface expression of S1P1.

Abstract: Disclosed are XBP-1/IRE-1 inhibitors having formula disclosed herein. Methods of making and using these inhibitors for the treatment of cancer, in particular B cell cancers, are also disclosed. Also disclosed is a genetic XBP-1-knockout cancer mouse model. In still further aspects, the disclosed subject matter relates to methods for treating oncological and inflammatory disorders in a patient. For example, disclosed herein are methods whereby an effective amount of a compound or composition disclosed herein is administered to a patient having an oncological disorder, for example B-cell chronic lymphocytic leukemia (CLL), and who is in need of treatment thereof. XBP-1 deficiency causes leukemic cells to acquire phenotypes that are disadvantageous for their survival, such as compromised BCR signaling capability and increased surface expression of S1 P1.

Abstract: A fluorescent dye, a structure of a fluorescent storage media and method using thereof, are disclosed. The fluorescent dye of the present invention comprises an organic violet fluorescent compound having a chemical structure (I) is suitable for using a short wavelength laser having a wavelength less than 500 nm as an excitation source. When a short wavelength laser is used for exciting the organic violet fluorescent compound (I), a fluorescence having an emission wavelength larger than 500 nm is induced, and a reading signal can be provided by detecting the intensity of the fluorescence radiation.

Abstract: A safety socket comprising a socket, a partition board, a hood and a cover is disclosed. A sliding partition board mounted between the socket and the hood is provided. One end of the partition board covers the socket and the other end extends to the outer part of the socket to form a handle. Two spots are provided in the main body of the partition board which correspond to the receptacles of the socket. On the underside of the partition board a column protrudes with a spring chamber retaining a spring. When the socket is not in use the spring loaded partition board automatically disaligns itself with the receptacles. To use the socket, simply pull back on the handle until the receptacles and the slots on the partition board are aligned.