Abstract: A smart city management system may enable creating a digital twin of the smart city based on mapping lidar data for the smart city and radio frequency data for the smart city; determining placement of a set of network devices in the smart city based on the created digital twin; and providing a visualization of the determined placement of the set of network devices.

Abstract: In one embodiment, a method includes by one or more computing devices, accessing an image including a hand of a user of a head-mounted display at a first time. The method includes generating, from at least the image, a virtual object representation of the hand, defined in a virtual environment that includes at least one other virtual object. The method includes rendering a first image of the virtual environment comprising a first portion of the hand of the user at a first frame rate, and determining a second viewpoint of the user at a second time. The method includes rendering a second image of the virtual environment comprising a second portion of the hand of the user at a second frame rate. The method includes providing, to a set of light emitters of the head-mounted display, instructions to display the second image.

Abstract: Combined administration of a selective glucocorticoid receptor modulator (SGRM; e.g., relacorilant or exicorilant) and a cancer therapeutic (e.g., a taxane or antiandrogen) is useful for identifying elevated cortisol activity in patients with cancer or with Cushing's syndrome, and for treating patients with cancer (e.g., ovarian, pancreatic, or prostate cancer). An at least 40% change in RNA levels encoding CDKN1C, TNFRSF17, BRIP1, PDK1, CLEC10A, FPR3, CCR2, LTLRB4, or CD86 indicates that the patient with cancer is likely to benefit from the combined treatment (e.g., likely to have longer survival than similar patients not receiving combined treatment). An active SGRM dose is identified where RNA levels encoding CDKN1C, TNFRSF17, BRIP1, or PDK1 decrease, or where RNA levels encoding CLEC10A, FPR3, CCR2, LTLRB4, and CD86 increase, by at least 40%. Changes in RNA levels encoding CLEC10A, FPR3, CCR2, LTLRB4, and CD86 identify patients with cancer or with Cushing's having elevated cortisol activity.

Abstract: In certain embodiments, a method for analyzing a retinal image of an eye for retinal disease includes conforming a contact portion of a patient interface to the surface of the eye. A camera stem is received by a sleeve of the patient interface. Light from the camera stem is directed by the sleeve towards the interior of the eye, and light reflected from the interior of the eye is directed by the sleeve towards the camera. Image data generated by the camera is output to a computer. Options representing actions that facilitate analysis of the retinal image are displayed at the computer. The retinal image is displayed at the computer according to the image data. A selection of an option is received by the computer. The action represented by the option is performed by the computer to facilitate analysis of the retinal image.

Abstract: In certain embodiments, a system generates image data for an image of the interior of an eye. The system includes a camera apparatus and patient interface. The camera apparatus includes a camera stem, sensor, processor, and communication interface. The camera stem has illuminators that emits light and an objective lens system that receives light. The sensor generates a signal in response to detecting light received by the objective lens system. The processor generates image data from the signal, and the communication interface outputs the image data. The patient interface includes a contact portion and a sleeve. The contact portion is shaped to conform to an anterior eye surface of the eye. The sleeve is shaped to receive the camera stem. The sleeve directs light from the illuminators towards the eye interior, and directs light reflected from the eye interior towards the camera apparatus.

Abstract: A workstation is described for mounting specimens into a cryotransfer holder at cryogenic temperature. The workstation allows rotation about the cryotransfer holder axis to improve access to the sample placement area on the holder and to facilitate easy removal and retrieval of the sample after imaging. The cryotransfer holder includes a cylindrical dewar configured to maintain a constant center of mass about the holder axis regardless of orientation of the dewar.

Abstract: A pulsed laser apparatus for milling a sample is described. The apparatus includes a pulsed laser, a scan head for scanning a beam from the pulsed laser across the sample an F-theta lens for focusing the scanned beam onto the sample and a confocal detector for detection of ablation depth. Methods of pulsed laser milling are also described.

Abstract: A pulsed laser apparatus for milling a sample is described. The apparatus includes a pulsed laser, a scan head for scanning a beam from the pulsed laser across the sample and an F-theta lens for focusing the scanned beam onto the sample. The apparatus may also include a liquid bath for milling the sample under the liquid, such as water. Methods of pulsed laser milling are also described.

Abstract: Apparatuses for collection of wavelength resolved and angular resolved cathodoluminescence (WRARCL) emitted from a sample exposed to an electron beam (e-beam) or other excitation beams are described. Cathodoluminescence light (CL) may be emitted from a sample at specific angles relative to the excitation beam and analyzed with respect to light-emitting and other optical phenomena. The described embodiments allow collection of WRARCL data more efficiently and with significantly fewer aberrations than existing systems.

Abstract: In an embodiment, a headset display device includes a central processor and multiple projector integrated circuits for eyes of a wearer of the headset display device. Each eye of the wear is associated with at least three projector integrated circuits. Each of the three projector integrated circuits is communicatively coupled to the central processor. Each projector integrated circuit includes a first integrated circuit including a light emitter array having monochrome light emitters of a single color, and a second integrated circuit coupled to the first integrated circuit. The second integrated circuit includes a graphics processor configured to generate transformed image data. The graphics processor is configured to provide the transformed image data to the first integrated circuit. The first integrated circuit is configured to output the transformed image data using the light emitter array.

Abstract: Polypeptide inhibitors of SARS-COV-2 are disclosed comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS: 1-17, 19-21, 23-34 and 100-101, and their use for treating and limiting development of SARS-COV-2 infection.

Abstract: In one embodiment, a method includes accessing display timing information associated with a display, and determining, based on the display timing information, one or more rendering requirements for a plurality of portions of the display. For each portion of the display, the method may determine a current viewpoint of a user, render, based on the current viewpoint of the user, pixel values for that portion of the display in accordance with the associated rendering requirement, and send the rendered pixel values to be output by the display. The display timing information may include a waveform associated with an oscillation motion of a scanning assembly of the display, and/or a requested size for each portion of the plurality of portions of the display. The rendering requirements may include a timing interval for rendering and sending the pixel values for each of the plurality of portions of the display.

Abstract: In one embodiment, a computing system may access surfaces and texel data of an artificial reality scene. The surfaces may be generated based on a first viewing position of a viewer. The system may determine tiles on a display to test for a visibility of the surfaces from a second viewing position. The tiles may include first tiles that need more computational resources and second tiles that need less computational resources. The system may determine a tile order which interleaves the first and second tiles. The system may generate rays based on the tile order. The system may determine the visibility of the surfaces from the second viewing position based on the ray-surface intersections. The system may generate color values of a subframe based on the surface visibility and the texel data. The system may provide the color values to the display.

Abstract: Apparatuses for collection of upstream and downstream transmission electron microscopy (TEM) cathodoluminescence (CL) emitted from a sample exposed to an electron beam are described. A first fiber optic cable carries first CL light emitted from a first TEM sample surface, into a spectrograph. A second fiber optic cable carries second CL light emitted from a second TEM sample surface into the spectrograph. The first and second fiber optic cables are positioned such that the spectrograph produces a first light spectrum for the first fiber optic cable and a separate light spectrum for the second fiber optic cable. The described embodiments allow collection of TEM CL data in a manner that allows analyzing upstream and downstream TEM CL signals separately and simultaneously with an imaging spectrograph.

Abstract: In one embodiment, a method includes by one or more computing devices, accessing an image including a hand of a user of a head-mounted display at a first time. The method includes generating, from at least the image, a virtual object representation of the hand, defined in a virtual environment that includes at least one other virtual object. The method includes rendering a first image of the virtual environment comprising a first portion of the hand of the user at a first frame rate, and determining a second viewpoint of the user at a second time. The method includes rendering a second image of the virtual environment comprising a second portion of the hand of the user at a second frame rate. The method includes providing, to a set of light emitters of the head-mounted display, instructions to display the second image.

Abstract: In one embodiment, a computing system may access surfaces and texel data of an artificial reality scene. The surfaces may be generated based on a first viewing position of a viewer. The system may determine tiles on a display to test for a visibility of the surfaces from a second viewing position. The tiles may include first tiles that need more computational resources and second tiles that need less computational resources. The system may determine a tile order which interleaves the first and second tiles. The system may generate rays based on the tile order. The system may determine the visibility of the surfaces from the second viewing position based on the ray-surface intersections. The system may generate color values of a subframe based on the surface visibility and the texel data. The system may provide the color values to the display.

Abstract: An alert system detects when an auditory prosthesis recipient is wearing her sound processor. When the processor is not worn, the alert system signals a secondary device, such as an accessory, to provide some other form of tactile stimulation to allow the recipient to be made aware of certain auditory stimuli she is not receiving via the auditory prosthesis. Thus, the alert system can effectively “hear” for the recipient. Since many auditory prosthesis recipients are, for all practical purposes, completely deaf without their external sound processors attached and operational, such an alert system increases the recipient's safety, convenience, and quality of life.

Abstract: Pest control systems and methods are described. The systems comprise a portable electronic device which is configured to identify one or more of multiple PCDs within a range of a portable electric device which have been activated, and to provide an indication to a user corresponding to at least one of the identified activated PCDs.

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Abstract: An assembly is used for chemical injection through a wellhead to a capillary line in a well. A capillary hanger installs in the wellhead to support the capillary line. A no-return valve of the capillary hanger prevents fluid communication uphole from the supported capillary line. An injection module mounts above a gate valve on the wellhead and includes a movable mandrel disposed therein. Hydraulic pressure applied to a piston chamber in the module extends the mandrel through the open gate valve so that a distal end of the mandrel can open the no-return valve. At this point, chemical injection introduced into the module can communicate through a flow bore of the extended mandrel, through the open non-return valve, and on through the supported capillary line in the well.