Abstract: This disclosure includes multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (V?1) chain of a ?? T cell receptor (TCR); and the Fc region comprises an PD-L1 binding site. This disclosure also includes compositions and pharmaceutical compositions comprising such multispecific antibodies, and methods of making such multispecific antibodies. The present disclosure also includes methods of treatment and medical uses involving the multispecific antibodies.

Abstract: The present disclosure provides, among other things, a method of isolating and expanding gamma delta (??) T cells, wherein the method comprises: (a) isolating non-hematopoeitic tissue by biopsy or explant, and (b) culturing the isolated non-hematopoeitic tissue in the absence of a three-dimensional scaffold or grid, thereby expanding and isolating gamma delta (??) T cells.

Abstract: The present invention relates to a method for the isolation of lymphocytes (in particular ?? T cells) from a non-haematopoietic tissue sample comprising the steps of culturing a non-haematopoietic tissue sample which is an intact biopsy obtained from a non-haematopoietic tissue in the presence of Interleukin-2 (IL-2) and Interleukin-15 (IL-15); and collecting a population of lymphocytes cultured from the non-haematopoietic tissue sample. Methods of subsequent expansion are provided, as well as populations of isolated cells obtained by the method and uses thereof.

Abstract: A method and a system for exposing malicious mobile activity by exploiting signal-based gestures can be provided so that an emergency service can detect an emergency incident in an area and communicate with one or more user(s) of one or more mobile end devices in the incident area and instruct the one or more users to perform a gesture with their end device(s). Then the signal and/or location data of the one or more user end device(s) in the incident area can be analyzed to verify whether the one or more user(s) in the incident area are non-malicious or malicious actors.

Abstract: An audio/visual environment includes a battery assembly. The battery assembly includes a cell array, a battery connector, an interface, protection circuitry, at least one sensor, and at least one processor. The battery connector is configured to electrically connect the cell array with external devices. The protection circuitry electrically couples the battery connector to the cell array and is configured to electrically decouple the cell array from the battery connector in response to an electrical fault. The at least one sensor is configured to measure status information of the cell array and/or the battery assembly. The at least one processor is configured to identify, utilizing the at least one sensor, the status information, and transmit, utilizing the interface, the status information to an external device.

Abstract: A battery power station including a top panel, a base, and side panels which define a structure, and a first removable end panel and a second removable end panel. The battery power station includes an electronics compartment within the structure including at least one printed circuit board, and a battery compartment within the structure configured to receive a battery pack module. The base includes lateral protrusions having a hook structure configured to interdigitate with corresponding hook structure of the side panels forming a seal between the base and the side panels. The first and second removable end panels include a shell having protrusions extending from an inner surface of the shell and around a periphery of the shell, the protrusions configured to create a seal with the structure forming a seal between the structure and the first and second removable end panels.

Abstract: In one embodiment, a power storage system includes a movable cart, an external frame, a rechargeable battery, and an electronic system. The movable cart includes a support frame. The support frame includes a base, a plurality of sidewalls mounted vertically with respect to the base, a lid mounted with respect to the plurality of sidewalls, and a set of wheels mounted with respect to the base. The external frame is mounted with respect to the base and is configured to extend around the plurality of sidewalls, where the plurality of sidewalls are accessible from a position outside of the external frame. The electronic system includes at least one output electrical receptacle and at least one input electrical receptacle. The electronic system is configured to electrically connect with the rechargeable battery, and the rechargeable battery and the electronic system are mounted with respect to the movable cart.

Abstract: An audio/visual environment includes a sodium-based battery assembly. The battery assembly includes a sodium-based cell array, a battery connector, an interface, protection circuitry, at least one sensor, and at least one processor. The cell array includes at least one sodium-based cell that is configured to utilize sodium ions as charge carriers during charge and discharge. The battery connector is configured to electrically connect the cell array with external devices. The protection circuitry electrically couples the battery connector to the cell array and is configured to electrically decouple the cell array from the battery connector in response to an electrical fault. The at least one sensor is configured to measure status information of the cell array and/or the battery assembly. The at least one processor is configured to identify, utilizing the at least one sensor, the status information, and transmit, utilizing the interface, the status information to an external device.

Abstract: The present disclosure describes a power storage system and, more particularly, a portable power storage system. The portable power storage system may include a movable cart, a power storage module, and an electrical system electrically connected to the power storage module and configured to output electrical power. In some instances, the power storage system may further include a power generation module.

Abstract: A battery power station including a top panel, a base, and side panels which define a structure, and a first removable end panel and a second removable end panel. The battery power station includes an electronics compartment within the structure including at least one printed circuit board, and a battery compartment within the structure configured to receive a battery pack module. The base includes lateral protrusions having a hook structure configured to interdigitate with corresponding hook structure of the side panels forming a seal between the base and the side panels. The first and second removable end panels include a shell having protrusions extending from an inner surface of the shell and around a periphery of the shell, the protrusions configured to create a seal with the structure forming a seal between the structure and the first and second removable end panels.

Abstract: The invention relates to methods for the isolation of non-haematopoietic tissue-resident lymphocytes, particularly ?? T cells. Such ?? T cells include non-V?2 cells, e.g. V?1, V?3 and V?5 cells and such non-haematopoietic tissues include skin and gut. It will be appreciated that such isolated non-haematopoietic tissue-resident lymphocytes find great utility in adoptive T cell therapies, chimeric receptor therapies and the like. Also provided are methods for expanding isolated tissue-resident lymphocytes, particularly methods for isolating and expanding ?? T cells. The present invention also relates to both individual cells and populations of cells produced by the methods described herein.

Abstract: The invention relates to a method for the isolation of lymphocytes (in particular ?? T cells) from a non-haematopoietic tissue sample comprising the steps of: culturing the non-haematopoietic tissue sample in the presence of (a) Interleukin-2 (IL-2) or Interleukin-9 (IL-9); (b) Interleukin-5 (IL-15); and (c) Interleukin-21 (IL-21); and collecting a population of lymphocytes cultured from the non-haematopoietic tissue sample. Methods of subsequent expansion are provided, as well as populations of isolated cells obtained by the method and uses thereof.

Abstract: The present invention relates to a method for the isolation of lymphocytes (in particular ?? T cells) from a non-haematopoietic tissue sample comprising the steps of culturing a non-haematopoietic tissue sample which is an intact biopsy obtained from a non-haematopoietic tissue in the presence of Interleukin-2 (IL-2) and Interleukin-15 (IL-15); and collecting a population of lymphocytes cultured from the non-haematopoietic tissue sample. Methods of subsequent expansion are provided, as well as populations of isolated cells obtained by the method and uses thereof.

Abstract: An apparatus and method for the production of radioisotopes utilizing an energy recovery linac. The ERL system is composed of an electron beam source, multiple superconducting radio frequency cavities operating at 4.5 K, a thin radiator, a target material, and a beam dump. The accompanying method discloses the use of the ERL system to generate desired radioisotopes via target interaction with bremsstrahlung photons while allowing recovery of a substantial portion of the electron beam energy before the beam is extracted to the beam dump.

Abstract: An ultra-compact free electron laser comprising a pair of opposed superconducting cavities that produce identical electron beams moving in opposite directions such that each set of superconducting cavities accelerates one electron beam and decelerates the other electron beam. Such an arrangement, allows the energy used to accelerate one beam to be recovered and used again to accelerate the second beam, thus, each electron beam is decelerated by a different structure than that which accelerated it so that energy exchange rather than recovery is achieved resulting in a more compact and highly efficient apparatus.