Patents by Inventor Andrew J. Armstrong

Andrew J. Armstrong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKERS AND TREATMENTS FOR METASTATIC CANCER
    Publication number: 20190271703
    Abstract: The current disclosure relates to biomarkers for chemo-residual tumor cells cancer in a subject and methods of treating same.
    Type: Application
    Filed: October 26, 2017
    Publication date: September 5, 2019
    Inventors: Robin E. Bachelder, Gabi Hanna, Greg Palmer, Andrew J. Armstrong, Donald P. McDonnell
  • METHOD OF ISOLATING CIRCULATING TUMOR CELLS
    Publication number: 20190107542
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Application
    Filed: November 30, 2018
    Publication date: April 11, 2019
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting
  • Method of isolating circulating tumor cells
    Patent number: 10161939
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: December 25, 2018
    Assignees: Duke University, Janssen Diagnostics, LLC
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting
  • Compositions and Methods for the Capture and Characterization of Circulating Tumor Cells
    Publication number: 20180231560
    Abstract: This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.
    Type: Application
    Filed: September 15, 2015
    Publication date: August 16, 2018
    Inventors: Galla Chandra Rao, Mark C. Connelly, Rengasamy BOOMINATHAN, Tian Zhang, Mariano A. Garcia-Blanco, Andrew J. Armstrong
  • METHOD OF ISOLATING CIRCULATING TUMOR CELLS
    Publication number: 20160077097
    Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.
    Type: Application
    Filed: May 31, 2013
    Publication date: March 17, 2016
    Inventors: Galla Chandra Rao, Mark C. Connelly, Mariano A. Garcia-Blanco, Andrew J. Armstrong, Rhonda L. Bitting