Abstract: A method includes training a machine learning model on a training data set, that describes input parameters to and corresponding output parameters from manufacturing equipment, using at least one learning algorithm to obtain a physics model that describes evolution of a state space of the manufacturing equipment, configuring a machine-learning-based controller agent to generate commands for the physics model that modify settings of a simulation of the manufacturing equipment by the physics model such that, responsive to input data, the physics model generates corresponding predicted output parameters, and training the machine-learning-based controller agent on the settings and corresponding predicted output parameters using at least one other learning algorithm.